THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS

Ali Yılmaz Altay; Ekrem Yavuz; Aysel Bayram; Cenk Yaşa; Hamdullah Sözen; Semen Önder

Makale detayları

THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS

Yazarlar:

Ali Yılmaz Altay | Ekrem Yavuz | Aysel Bayram | Cenk Yaşa | Hamdullah Sözen | Semen Önder

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 1, pp.54-60

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314925

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: To investigate whether beta catenin and Forkhead box protein P1 FOXP1 play a role in pathogenesis of polypoid endometriosis PE. Material and Method: Our study included fifteen cases of PE. Clinical findings were gathered from archived files of relevant clinics and pathology reports. All glass slides were re-examined for confirmation of the diagnosis and the detection of additional microscopic findings. An immunohistochemical examination was performed using anti beta catenin and FOXP1 antibodies in fifteen cases of PE, and in a control group that contained nine cases of endometrial polyps EP and nine cases of conventional ovarian endometriosis OE. Result: Stromal nuclear beta catenin expression was observed in six cases in PE, five cases in EP and one case in the OE group. Stromal FOXP1 staining in PE and EP was significantly reduced as compared to OE. Five PE and two EP cases showed stromal FOXP1 staining while all the OE cases showed stromal FOXP1 staining. The Stromal FOXP1 staining was statistically significant between PE vs OE p0.002 and EP vs OE p0.023 cases. There was no difference between PE and the control cases in terms of nuclear beta catenin staining p0.69. There was no correlation between these two antibodies and histologic features. Conclusion: The loss of stromal FOXP1 is another biological difference of PE and the overall similarity of expression of FOXP1between PE and EP could be regarded as a contributing factor for polyp formation.

 Objective: To investigate whether beta catenin and Forkhead box protein P1 FOXP1 play a role in pathogenesis of polypoid endometriosis PE. Material and Method: Our study included fifteen cases of PE. Clinical findings were gathered from archived files of relevant clinics and pathology reports. All glass slides were re-examined for confirmation of the diagnosis and the detection of additional microscopic findings. An immunohistochemical examination was performed using anti beta catenin and FOXP1 antibodies in fifteen cases of PE, and in a control group that contained nine cases of endometrial polyps EP and nine cases of conventional ovarian endometriosis OE. Result: Stromal nuclear beta catenin expression was observed in six cases in PE, five cases in EP and one case in the OE group. Stromal FOXP1 staining in PE and EP was significantly reduced as compared to OE. Five PE and two EP cases showed stromal FOXP1 staining while all the OE cases showed stromal FOXP1 staining. The Stromal FOXP1 staining was statistically significant between PE vs OE p0.002 and EP vs OE p0.023 cases. There was no difference between PE and the control cases in terms of nuclear beta catenin staining p0.69. There was no correlation between these two antibodies and histologic features. Conclusion: The loss of stromal FOXP1 is another biological difference of PE and the overall similarity of expression of FOXP1between PE and EP could be regarded as a contributing factor for polyp formation.

 Objective: To investigate whether beta catenin and Forkhead box protein P1 FOXP1 play a role in pathogenesis of polypoid endometriosis PE. Material and Method: Our study included fifteen cases of PE. Clinical findings were gathered from archived files of relevant clinics and pathology reports. All glass slides were re-examined for confirmation of the diagnosis and the detection of additional microscopic findings. An immunohistochemical examination was performed using anti beta catenin and FOXP1 antibodies in fifteen cases of PE, and in a control group that contained nine cases of endometrial polyps EP and nine cases of conventional ovarian endometriosis OE. Result: Stromal nuclear beta catenin expression was observed in six cases in PE, five cases in EP and one case in the OE group. Stromal FOXP1 staining in PE and EP was significantly reduced as compared to OE. Five PE and two EP cases showed stromal FOXP1 staining while all the OE cases showed stromal FOXP1 staining. The Stromal FOXP1 staining was statistically significant between PE vs OE p0.002 and EP vs OE p0.023 cases. There was no difference between PE and the control cases in terms of nuclear beta catenin staining p0.69. There was no correlation between these two antibodies and histologic features. Conclusion: The loss of stromal FOXP1 is another biological difference of PE and the overall similarity of expression of FOXP1between PE and EP could be regarded as a contributing factor for polyp formation.

 Amaç: Polipoid endometriozis PE patogenezinde Forkhead box protein P1 FOXP1 ve beta-kateninnin rolünün araştırılması. Gereç ve Yöntem: Çalışmaya 15 PE olgusu dahil edilmiştir. Klinik bilgiler hastaların tıbbi kayıtlarından ve patoloji raporlarından elde edilmiştir. Tüm mikroskopik preperatlar tanının doğrulanması ve ek mikroskopik özelliklerin tanımlanması amacıyla tekrar değerlendirilmiştir. FOXP1 ve beta-katenin antikorları kullanılarak 15 PE ve kontrol grubu olarak dokuz endometrial polip EP ve dokuz ovarian endometriozis OE olgusuna immünhistokimyasal inceleme yapılmıştır. Bulgular: Stromal nükleer beta-katenin boyanması altı PE, beş EP ve bir OE olgusunda gözlenmiştir. Stromal FOXP1 boyanması OE olgularına göre PE ve EP olgularında belirgin şekilde azalmış olup tüm OE olgularında stromal FOXP1 boyanması izlenirken beş PE ve iki EP olgusunda stromal FOXP1 boyanması saptanmıştır. PE ile OE ve EP ile OE olguları arasındaki stromal FOXP1 boyanması farkı anlamlıdır sırasıyla p0,002 ve p0,023. Beta-katenin ile PE ve kontrol grubu olguları arasında anlamlı fark bulunmamıştır p0,69. Histolojik özelliklerle bu antikorların pozitifliği arasında ilişki yoktur. Sonuç: PE olgularındaki FOXP1 kaybı PE ve konvansiyonel endometriosis arasındaki bir diğer biyolojik fark olarak tanımlanabilir. Ayrıca PE ve EP olgularındaki stromal FOXP1 boyanmasındaki benzerlik FOXP1in polip oluşumunda rolü olduğunu düşündürmektedir.

Makale detayları

THE ROLE OF BETA-CATENIN AND FOXP1 IN THE PATHOGENESIS OF POLYPOID ENDOMETRIOSIS

Yazarlar:

Ali Yılmaz Altay | Ekrem Yavuz | Aysel Bayram | Cenk Yaşa | Hamdullah Sözen | Semen Önder

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 1, pp.54-60

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314925

pISSN:

1305-6441

Endometriosis

polyp

immunohistochemistry

FOXP1

beta-cateninEndometriozis

polip

immünhistokimya

FOXP1

beta-katenin

Sayı

Makale detayları

Yazarlar: Ali Yılmaz Altay | Ekrem Yavuz | Aysel Bayram | Cenk Yaşa | Hamdullah Sözen | Semen Önder

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 1, pp.54-60

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001314925

pISSN: 1305-6441

Sayı

Yazarlar:

Ali Yılmaz Altay | Ekrem Yavuz | Aysel Bayram | Cenk Yaşa | Hamdullah Sözen | Semen Önder

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.87 Issue 1, pp.54-60

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314925

pISSN:

1305-6441