The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in  Patients with Guillain-Barré Syndrome Independent of Infection

Sirma Geyik; Hakan Bozkurt; Münife Neyal; Remzi Yigiter; Samiye Kuzudisli; Seval Kul

doi:https://doi.org/10.17546/msd.90383

Makale detayları

The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection

Yazarlar:

Sirma Geyik | Hakan Bozkurt | Münife Neyal | Remzi Yigiter | Samiye Kuzudisli | Seval Kul

Yayıncı:

Zafer AKAN

Dergi:

Medical Science and Discovery 2016 Vol.3 Issue 8, pp.305-11

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000826703

Sıklık:

Aylık

eISSN:

2148-6832

pISSN:

2148-6832

DOI:

https://doi.org/10.17546/msd.90383

Özet:

 


Objective:  In the present study, we aimed to determine the predictive value of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of Guillain-Barré Syndrome (GBS). 

Material and Methods: This retrospective study enrolled 94 GBS patients and a control group of 101 healthy subjects.

Results: GBS patients had significantly higher NLR, C- Reactive Protein (CRP) and Erythrocyte  Sedimentation Rate (ESR) values at presentation than the healthy control group (p < 0.001, p < 0.001, p < 0.001, respectively). Patients unresponsive to IVIg therapy had significantly higher NLR values at the time of admission in comparison to responsive patients (p=0.001). NLR was significantly and positively correlated with the disease severity, CRP and ESR. A receiver operating characteristic (ROC) analysis of the ability of NLR to predict GBS showed a cutoff value of 3.5 (sensitivity 62.8%, specificity 90.1%). The cutoff value was 11 for CRP (sensitivity 52.7%, specificity 86%) and 12.3 for ESR (sensitivity 51.3%, specificity 82%). Exclusion of patients with signs of infection at presentation gave a NLR value of 3.2, which had a sensitivity of 61.6% and a specificity of 89.8% for predicting GBS.

Conclusion:  Whereas ESR and CRP lost their significance in predicting GBS. Unlike ESR and CRP, NLR might be a promising marker in GBS regardless of infection.

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Makale detayları

The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection

Yazarlar: Sirma Geyik | Hakan Bozkurt | Münife Neyal | Remzi Yigiter | Samiye Kuzudisli | Seval Kul

Yayıncı: Zafer AKAN

Dergi: Medical Science and Discovery 2016 Vol.3 Issue 8, pp.305-11

Belge Tipi: Makale

Yayın Tarihi: 8/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000826703

Sıklık: Aylık

eISSN: 2148-6832

pISSN: 2148-6832

DOI: https://doi.org/10.17546/msd.90383

Sayı

Yazarlar:

Sirma Geyik | Hakan Bozkurt | Münife Neyal | Remzi Yigiter | Samiye Kuzudisli | Seval Kul

Yayıncı:

Zafer AKAN

Dergi:

Medical Science and Discovery 2016 Vol.3 Issue 8, pp.305-11

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000826703

Sıklık:

Aylık

eISSN:

2148-6832

pISSN:

2148-6832

DOI:

https://doi.org/10.17546/msd.90383