The Effect of Quercetin and Quercetin-3-d-xyloside on Breast Cancer Proliferation and Migration

Tuğba Nurcan YÜKSEL; Esra BOZGEYİK; Muhammed YAYLA

doi:https://doi.org/10.30621/jbachs.1056769

Makale detayları

The Effect of Quercetin and Quercetin-3-d-xyloside on Breast Cancer Proliferation and Migration

Yazarlar:

Tuğba Nurcan YÜKSEL | Esra BOZGEYİK | Muhammed YAYLA

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Basic and Clinical Health Sciences 2022 Vol.6 Issue 2, pp.569-578

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000492916

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.1056769

Özet:

 

Background and Purpose: The aim of this study is to examine the migration, wound healing, colony formation and cytotoxic effects of reynotrin, quercetin derivative, in breast cancer cells.
Methods: In our study, CRL-4010, MCF7 and MDA-MB-231 cells were used to evaluate the different effects of reynoutrin on breast cancer. The IC50 concentration (400 µg/ml) of reynotrin, quercetin and cisplatin in the cells was determined. For cytotoxicity assessments, varying concentrations of quercetin, reynoutrin and cisplatin were applied and incubated 24h and 48h. In addition, to examine its effects on migration, cells were seeded in 6-well plates and incubated for 24 hours. Morever, to assess colony formation, test cells were seeded in 12-well plates at a concentration of 1000 cells/well and incubated overnight.
Results: These results indicated that Reynoutrin markedly inhibit the cell viability in breast cancer.
Conclusion: We firstly revealed that Reynoutrin suppressed the progression of breast cancer   induction and may provide a potential therapeutic target for breast cancer treatment. More detailed studies are needed to show this effect of reynoutrin.

Makale detayları

The Effect of Quercetin and Quercetin-3-d-xyloside on Breast Cancer Proliferation and Migration

Yazarlar: Tuğba Nurcan YÜKSEL | Esra BOZGEYİK | Muhammed YAYLA

Yayıncı: Dokuz Eylul University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Basic and Clinical Health Sciences 2022 Vol.6 Issue 2, pp.569-578

Belge Tipi: Makale

Yayın Tarihi: 5/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000492916

Sıklık: Üç Yıllık

eISSN: 2564-7288

DOI: https://doi.org/10.30621/jbachs.1056769

Sayı

Yazarlar:

Tuğba Nurcan YÜKSEL | Esra BOZGEYİK | Muhammed YAYLA

Yayıncı:

Dokuz Eylul University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Basic and Clinical Health Sciences 2022 Vol.6 Issue 2, pp.569-578

Belge Tipi:

Makale

Yayın Tarihi:

5/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000492916

Sıklık:

Üç Yıllık

eISSN:

2564-7288

DOI:

https://doi.org/10.30621/jbachs.1056769