Predictive Factors for Non-sentinel Lymph Node Metastasis of Breast Cancer

İbrahim Ali Özemir; Muhammet Ali Aydemir; Leyla Zeynep Tigrel; Hakan Baysal

Makale detayları

Predictive Factors for Non-sentinel Lymph Node Metastasis of Breast Cancer

Yazarlar:

İbrahim Ali Özemir | Muhammet Ali Aydemir | Leyla Zeynep Tigrel | Hakan Baysal

Yayıncı:

Marmara University

Ana Başlıklar:

General Surgery

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.357-361

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352313

pISSN:

2459-1459

Anahtar kelimeler:

Özet:

 Objective: The indications for axillary dissection after sentinel lymph node biopsy SLNB in breast cancer BC is gradually decreasing, even for selected patients with positive SLNB. Increased predictability of Non-sentinel lymph node Non-SLN metastasis could prevent unnecessary axillary dissection and even eliminate the need for SLNB. In this study we aimed to investigate the clinical and the pathological factors that affect Non-SLN metastasis. Methods: Early breast cancer patients who underwent SLNB between 2013 and 2018 were retrospectively included in the study. Patients were divided into 3 groups; Group-1 SLNB negative patients, Group-2 SLNB positive but Non-SLN negative patients and Group-3 both SLNB and non-SLN positive patients. Groups were compared in terms of demographic data, tumor size, SLN size, Ki-67 percentages, and hormone receptor status. Results: Seventy-six 36.4 out of 206 patients had positive SLNB. Non-SLN metastases were detected in 33 42.7 patients. Mean tumor size found significantly higher in Group 3 Group-1, 2 and 3 respectively; 20.59.7mm, 21.99.3mm, 25.19.5mm; p.01. The mean SLN size was significantly bigger in Group-3 Group-1, 2 and 3 respectively, 13.15.6mm, 13.98.2mm, 16.86.5mm; p.01. Rate of patients with Ki-67 index higher than 14 was 84.3 in Group-3, 59.1 in Group-2 and 49.2 in Group-1p.01. A statistically significant difference was not detected between the groups in terms of hormone receptor status. Conclusion: Tumor size, SLN size and Ki-67 percentages have importance in predicting the presence of Non-SLN metastasis in BC patients. These factors should also be taken into account for the management of the axillary metastasis and adjuvant treatment for BC.

 Objective: The indications for axillary dissection after sentinel lymph node biopsy SLNB in breast cancer BC is gradually decreasing, even for selected patients with positive SLNB. Increased predictability of Non-sentinel lymph node Non-SLN metastasis could prevent unnecessary axillary dissection and even eliminate the need for SLNB. In this study we aimed to investigate the clinical and the pathological factors that affect Non-SLN metastasis. Methods: Early breast cancer patients who underwent SLNB between 2013 and 2018 were retrospectively included in the study. Patients were divided into 3 groups; Group-1 SLNB negative patients, Group-2 SLNB positive but Non-SLN negative patients and Group-3 both SLNB and non-SLN positive patients. Groups were compared in terms of demographic data, tumor size, SLN size, Ki-67 percentages, and hormone receptor status. Results: Seventy-six 36.4 out of 206 patients had positive SLNB. Non-SLN metastases were detected in 33 42.7 patients. Mean tumor size found significantly higher in Group 3 Group-1, 2 and 3 respectively; 20.59.7mm, 21.99.3mm, 25.19.5mm; p.01. The mean SLN size was significantly bigger in Group-3 Group-1, 2 and 3 respectively, 13.15.6mm, 13.98.2mm, 16.86.5mm; p.01. Rate of patients with Ki-67 index higher than 14 was 84.3 in Group-3, 59.1 in Group-2 and 49.2 in Group-1p.01. A statistically significant difference was not detected between the groups in terms of hormone receptor status. Conclusion: Tumor size, SLN size and Ki-67 percentages have importance in predicting the presence of Non-SLN metastasis in BC patients. These factors should also be taken into account for the management of the axillary metastasis and adjuvant treatment for BC.

 Objective: The indications for axillary dissection after sentinel lymph node biopsy SLNB in breast cancer BC is gradually decreasing, even for selected patients with positive SLNB. Increased predictability of Non-sentinel lymph node Non-SLN metastasis could prevent unnecessary axillary dissection and even eliminate the need for SLNB. In this study we aimed to investigate the clinical and the pathological factors that affect Non-SLN metastasis. Methods: Early breast cancer patients who underwent SLNB between 2013 and 2018 were retrospectively included in the study. Patients were divided into 3 groups; Group-1 SLNB negative patients, Group-2 SLNB positive but Non-SLN negative patients and Group-3 both SLNB and non-SLN positive patients. Groups were compared in terms of demographic data, tumor size, SLN size, Ki-67 percentages, and hormone receptor status. Results: Seventy-six 36.4 out of 206 patients had positive SLNB. Non-SLN metastases were detected in 33 42.7 patients. Mean tumor size found significantly higher in Group 3 Group-1, 2 and 3 respectively; 20.59.7mm, 21.99.3mm, 25.19.5mm; p.01. The mean SLN size was significantly bigger in Group-3 Group-1, 2 and 3 respectively, 13.15.6mm, 13.98.2mm, 16.86.5mm; p.01. Rate of patients with Ki-67 index higher than 14 was 84.3 in Group-3, 59.1 in Group-2 and 49.2 in Group-1p.01. A statistically significant difference was not detected between the groups in terms of hormone receptor status. Conclusion: Tumor size, SLN size and Ki-67 percentages have importance in predicting the presence of Non-SLN metastasis in BC patients. These factors should also be taken into account for the management of the axillary metastasis and adjuvant treatment for BC.

 Objective: The indications for axillary dissection after sentinel lymph node biopsy SLNB in breast cancer BC is gradually decreasing, even for selected patients with positive SLNB. Increased predictability of Non-sentinel lymph node Non-SLN metastasis could prevent unnecessary axillary dissection and even eliminate the need for SLNB. In this study we aimed to investigate the clinical and the pathological factors that affect Non-SLN metastasis. Methods: Early breast cancer patients who underwent SLNB between 2013 and 2018 were retrospectively included in the study. Patients were divided into 3 groups; Group-1 SLNB negative patients, Group-2 SLNB positive but Non-SLN negative patients and Group-3 both SLNB and non-SLN positive patients. Groups were compared in terms of demographic data, tumor size, SLN size, Ki-67 percentages, and hormone receptor status. Results: Seventy-six 36.4 out of 206 patients had positive SLNB. Non-SLN metastases were detected in 33 42.7 patients. Mean tumor size found significantly higher in Group 3 Group-1, 2 and 3 respectively; 20.59.7mm, 21.99.3mm, 25.19.5mm; p.01. The mean SLN size was significantly bigger in Group-3 Group-1, 2 and 3 respectively, 13.15.6mm, 13.98.2mm, 16.86.5mm; p.01. Rate of patients with Ki-67 index higher than 14 was 84.3 in Group-3, 59.1 in Group-2 and 49.2 in Group-1p.01. A statistically significant difference was not detected between the groups in terms of hormone receptor status. Conclusion: Tumor size, SLN size and Ki-67 percentages have importance in predicting the presence of Non-SLN metastasis in BC patients. These factors should also be taken into account for the management of the axillary metastasis and adjuvant treatment for BC.

Makale detayları

Predictive Factors for Non-sentinel Lymph Node Metastasis of Breast Cancer

Yazarlar:

İbrahim Ali Özemir | Muhammet Ali Aydemir | Leyla Zeynep Tigrel | Hakan Baysal

Yayıncı:

Marmara University

Ana Başlıklar:

General Surgery

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.357-361

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352313

pISSN:

2459-1459

Breast cancer

Non-sentinel lymph node

Lymph node metastasis

Sayı

Makale detayları

Predictive Factors for Non-sentinel Lymph Node Metastasis of Breast Cancer

Yazarlar: İbrahim Ali Özemir | Muhammet Ali Aydemir | Leyla Zeynep Tigrel | Hakan Baysal

Yayıncı: Marmara University

Ana Başlıklar: General Surgery

Dergi: Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.357-361

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001352313

pISSN: 2459-1459

Breast cancer

Non-sentinel lymph node

Lymph node metastasis

Sayı

Yazarlar:

İbrahim Ali Özemir | Muhammet Ali Aydemir | Leyla Zeynep Tigrel | Hakan Baysal

Yayıncı:

Marmara University

Ana Başlıklar:

General Surgery

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 2, pp.357-361

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001352313

pISSN:

2459-1459