Ipomoea pes-caprae Linn protects mice bone marrow cells  against chemo-radiotherapy induced genotoxicity

N.A.

Makale detayları

Ipomoea pes-caprae Linn protects mice bone marrow cells against chemo-radiotherapy induced genotoxicity

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.395-403

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345968

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Chemo-radiotherapy is the gold standard for the non-surgical management of cancer disease. However, patient receiving chemo-radiotherapy may lead to the genotoxicity of bone marrow. Therefore, Ipomoea pes-caprae as a potential chemoprotectant was evaluated against chemo-radiotherapy induced genotoxicity in C57BL mice. The present investigation evaluated the protective effect of Ipomoea pes-caprae against chemo-radiotherapy induced genotoxicity in mouse bone-marrow cells during the treatment of Melanoma cancer B16F10. Methanol extract of the plant was administered to mice 25 and 50 mgkg b. wt. with the treatment dose of chemotherapy Dacarbazine 50 mgkg b. wt. and radiotherapy 8Gy in 4 fractions, 2Gy in every 10th day to the tumor only over a treatment time of 40 days. Significant increase p0.001 in the chromosomal aberrations were found for the tumor control, radiation control and dacarbazine administered groups. Significant increase in frequency of micronucleated polychromatic erythrocytes MNPCEs and micronucleated normochromatic erythrocytes MNNCEs was observed p0.01 in the tumor control, radiation control and dacarbazine administered groups, whereas the ratio of polychromatic and normochromatic erythrocytes PCEsNCEs was found to be decreased. Methanolic extract treated group has shown a statistically significant p0.01 reduction in the aberrant metaphase and number of chromosomal aberrations as compared to tumor radiation control. Aberrant metaphase and incidence of micronuclei formation was found to be decreased in the experimental groups administered with plant extracts. The results of the present study concluded that I. pes-caprae has potential chemo-protection against chemo-radiotherapy induced genotoxicity during treatment of melanoma cancer in mice, which support its candidature as a potential chemo-radioprotective agent for cancer patients undergoing chemo radiotherapy.

 Chemo-radiotherapy is the gold standard for the non-surgical management of cancer disease. However, patient receiving chemo-radiotherapy may lead to the genotoxicity of bone marrow. Therefore, Ipomoea pes-caprae as a potential chemoprotectant was evaluated against chemo-radiotherapy induced genotoxicity in C57BL mice. The present investigation evaluated the protective effect of Ipomoea pes-caprae against chemo-radiotherapy induced genotoxicity in mouse bone-marrow cells during the treatment of Melanoma cancer B16F10. Methanol extract of the plant was administered to mice 25 and 50 mgkg b. wt. with the treatment dose of chemotherapy Dacarbazine 50 mgkg b. wt. and radiotherapy 8Gy in 4 fractions, 2Gy in every 10th day to the tumor only over a treatment time of 40 days. Significant increase p0.001 in the chromosomal aberrations were found for the tumor control, radiation control and dacarbazine administered groups. Significant increase in frequency of micronucleated polychromatic erythrocytes MNPCEs and micronucleated normochromatic erythrocytes MNNCEs was observed p0.01 in the tumor control, radiation control and dacarbazine administered groups, whereas the ratio of polychromatic and normochromatic erythrocytes PCEsNCEs was found to be decreased. Methanolic extract treated group has shown a statistically significant p0.01 reduction in the aberrant metaphase and number of chromosomal aberrations as compared to tumor radiation control. Aberrant metaphase and incidence of micronuclei formation was found to be decreased in the experimental groups administered with plant extracts. The results of the present study concluded that I. pes-caprae has potential chemo-protection against chemo-radiotherapy induced genotoxicity during treatment of melanoma cancer in mice, which support its candidature as a potential chemo-radioprotective agent for cancer patients undergoing chemo radiotherapy.

 Chemo-radiotherapy is the gold standard for the non-surgical management of cancer disease. However, patient receiving chemo-radiotherapy may lead to the genotoxicity of bone marrow. Therefore, Ipomoea pes-caprae as a potential chemoprotectant was evaluated against chemo-radiotherapy induced genotoxicity in C57BL mice. The present investigation evaluated the protective effect of Ipomoea pes-caprae against chemo-radiotherapy induced genotoxicity in mouse bone-marrow cells during the treatment of Melanoma cancer B16F10. Methanol extract of the plant was administered to mice 25 and 50 mgkg b. wt. with the treatment dose of chemotherapy Dacarbazine 50 mgkg b. wt. and radiotherapy 8Gy in 4 fractions, 2Gy in every 10th day to the tumor only over a treatment time of 40 days. Significant increase p0.001 in the chromosomal aberrations were found for the tumor control, radiation control and dacarbazine administered groups. Significant increase in frequency of micronucleated polychromatic erythrocytes MNPCEs and micronucleated normochromatic erythrocytes MNNCEs was observed p0.01 in the tumor control, radiation control and dacarbazine administered groups, whereas the ratio of polychromatic and normochromatic erythrocytes PCEsNCEs was found to be decreased. Methanolic extract treated group has shown a statistically significant p0.01 reduction in the aberrant metaphase and number of chromosomal aberrations as compared to tumor radiation control. Aberrant metaphase and incidence of micronuclei formation was found to be decreased in the experimental groups administered with plant extracts. The results of the present study concluded that I. pes-caprae has potential chemo-protection against chemo-radiotherapy induced genotoxicity during treatment of melanoma cancer in mice, which support its candidature as a potential chemo-radioprotective agent for cancer patients undergoing chemo radiotherapy.

 Chemo-radiotherapy is the gold standard for the non-surgical management of cancer disease. However, patient receiving chemo-radiotherapy may lead to the genotoxicity of bone marrow. Therefore, Ipomoea pes-caprae as a potential chemoprotectant was evaluated against chemo-radiotherapy induced genotoxicity in C57BL mice. The present investigation evaluated the protective effect of Ipomoea pes-caprae against chemo-radiotherapy induced genotoxicity in mouse bone-marrow cells during the treatment of Melanoma cancer B16F10. Methanol extract of the plant was administered to mice 25 and 50 mgkg b. wt. with the treatment dose of chemotherapy Dacarbazine 50 mgkg b. wt. and radiotherapy 8Gy in 4 fractions, 2Gy in every 10th day to the tumor only over a treatment time of 40 days. Significant increase p0.001 in the chromosomal aberrations were found for the tumor control, radiation control and dacarbazine administered groups. Significant increase in frequency of micronucleated polychromatic erythrocytes MNPCEs and micronucleated normochromatic erythrocytes MNNCEs was observed p0.01 in the tumor control, radiation control and dacarbazine administered groups, whereas the ratio of polychromatic and normochromatic erythrocytes PCEsNCEs was found to be decreased. Methanolic extract treated group has shown a statistically significant p0.01 reduction in the aberrant metaphase and number of chromosomal aberrations as compared to tumor radiation control. Aberrant metaphase and incidence of micronuclei formation was found to be decreased in the experimental groups administered with plant extracts. The results of the present study concluded that I. pes-caprae has potential chemo-protection against chemo-radiotherapy induced genotoxicity during treatment of melanoma cancer in mice, which support its candidature as a potential chemo-radioprotective agent for cancer patients undergoing chemo radiotherapy.

Makale detayları

Ipomoea pes-caprae Linn protects mice bone marrow cells against chemo-radiotherapy induced genotoxicity

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Toxicology

Dergi: Journal of Research in Pharmacy Vol.27 Issue 1, pp.395-403

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001345968

pISSN: 2630-6344

Ipomoea pes-caprae

bone-marrow cells

chemotherapy

radiotherapy

chromosomal aberrations

micronuclei formation

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Toxicology

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.395-403

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345968

pISSN:

2630-6344