Evaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings

N.A.

Makale detayları

Evaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings

Yazarlar:

N.A.

Yayıncı:

Ataturk University

Ana Başlıklar:

Veteriner Bilimleri

Dergi:

Veterinary Sciences and Practices Vol.17 Issue 3, pp.98-102

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282151

pISSN:

2822-3608

Anahtar kelimeler:

Özet:

 In this study, whole blood cell count, metabolic and inflammatory biomarkers, and oxidative stress parameters were evaluated in dogs diagnosed with canine parvoviral enteritis by stool antigen testing performed 24-48 hours before any clinical findings arose. This study aimed to conduct effective evaluations of the status of the disease, the selection of treatment methods, and the prognosis of the disease. Thirty dogs with canine parvoviral enteritis positivity according to stool antigen test results 24-48 hours before the appearance of any clinical signs associated with parvoviral enteritis lethargy, vomiting, diarrhea, dehydration were evaluated together with 10 healthy dogs. In analyses of the dogs with canine parvoviral enteritis, significant decreases were found for white blood cell P  .001, neutrophil P  .001, and monocyte P  .011 counts and significant increases were found for alanine aminotransferase and aspartate aminotransferase P  .001 for both. Significant increases P  .001 were also determined for high-density lipoprotein, cholesterol, and triglyceride levels among the studied lipid metabolites and C-reactive protein, malondialdehyde, and paraoxonase-1 among inflammatory biomarkers. Significant decreases were found for total thiol P  .002 and native thiol P  .001, with which antioxidant levels were evaluated, and a significant increase was found for disulfide P  .001, with which oxidation was evaluated. It was concluded that early changes in blood samples taken 24-48 hours before the onset of clinical symptoms in dogs with CPV, as reflected by values of CBC and metabolic and inflammatory biomarkers, may provide information about the severity of the disease, the choice of medical treatments to be applied, and prognosis.

 In this study, whole blood cell count, metabolic and inflammatory biomarkers, and oxidative stress parameters were evaluated in dogs diagnosed with canine parvoviral enteritis by stool antigen testing performed 24-48 hours before any clinical findings arose. This study aimed to conduct effective evaluations of the status of the disease, the selection of treatment methods, and the prognosis of the disease. Thirty dogs with canine parvoviral enteritis positivity according to stool antigen test results 24-48 hours before the appearance of any clinical signs associated with parvoviral enteritis lethargy, vomiting, diarrhea, dehydration were evaluated together with 10 healthy dogs. In analyses of the dogs with canine parvoviral enteritis, significant decreases were found for white blood cell P  .001, neutrophil P  .001, and monocyte P  .011 counts and significant increases were found for alanine aminotransferase and aspartate aminotransferase P  .001 for both. Significant increases P  .001 were also determined for high-density lipoprotein, cholesterol, and triglyceride levels among the studied lipid metabolites and C-reactive protein, malondialdehyde, and paraoxonase-1 among inflammatory biomarkers. Significant decreases were found for total thiol P  .002 and native thiol P  .001, with which antioxidant levels were evaluated, and a significant increase was found for disulfide P  .001, with which oxidation was evaluated. It was concluded that early changes in blood samples taken 24-48 hours before the onset of clinical symptoms in dogs with CPV, as reflected by values of CBC and metabolic and inflammatory biomarkers, may provide information about the severity of the disease, the choice of medical treatments to be applied, and prognosis.

 In this study, whole blood cell count, metabolic and inflammatory biomarkers, and oxidative stress parameters were evaluated in dogs diagnosed with canine parvoviral enteritis by stool antigen testing performed 24-48 hours before any clinical findings arose. This study aimed to conduct effective evaluations of the status of the disease, the selection of treatment methods, and the prognosis of the disease. Thirty dogs with canine parvoviral enteritis positivity according to stool antigen test results 24-48 hours before the appearance of any clinical signs associated with parvoviral enteritis lethargy, vomiting, diarrhea, dehydration were evaluated together with 10 healthy dogs. In analyses of the dogs with canine parvoviral enteritis, significant decreases were found for white blood cell P  .001, neutrophil P  .001, and monocyte P  .011 counts and significant increases were found for alanine aminotransferase and aspartate aminotransferase P  .001 for both. Significant increases P  .001 were also determined for high-density lipoprotein, cholesterol, and triglyceride levels among the studied lipid metabolites and C-reactive protein, malondialdehyde, and paraoxonase-1 among inflammatory biomarkers. Significant decreases were found for total thiol P  .002 and native thiol P  .001, with which antioxidant levels were evaluated, and a significant increase was found for disulfide P  .001, with which oxidation was evaluated. It was concluded that early changes in blood samples taken 24-48 hours before the onset of clinical symptoms in dogs with CPV, as reflected by values of CBC and metabolic and inflammatory biomarkers, may provide information about the severity of the disease, the choice of medical treatments to be applied, and prognosis.

 Bu çalışmada, klinik bulgular görülmeden 24-48 saat önce, dışkıda yapılan antijen testi ile parvoviral enteritis CPV tanısı konulan köpeklerde, tam kan hücreleri CBC sayıları, metabolik ve inflamasyon biyobelirteçleri ve oksidatif stres parametreleri birlikte değerlendirilerek; hastalığın durumu, sağaltım yöntemlerinin seçimi ve hastalığın prognozu hakkında etkin değerlendirmelerin yapılması amaçlandı. Çalışmada, parvoviral enteritis ile ilişkili klinik belirtilerin durgunluk, kusma, ishal, dehidratasyon görülmesinden 24-48 saat önceki dışkı antijen testi sonucuna göre CPV pozitif olan 30 köpek ile, 10 sağlıklı köpek değerlendirildi. CPVli köpeklerde yapılan analizlerde, WBC P  ,001, nötrofil neut P  ,001 ve monosit mono P  ,011 sayılarında anlamlı düşüşler, ve alanin aminotransferaz ALT ve aspartat aminotransferaz AST değerlerinde anlamlı artışlar P  ,001 saptandı. Lipid metabolitlerinden yüksek dansiteli lipoprotein HDL, kolesterol Chl ve trigliserit Tg düzeylerinde ve inflamasyon biyobelirteçlerinden C-reaktif protein CRP, malondialdehit MDA ve paraoksanaz-1 PON-1 değerlerinde anlamlı artışlar P  ,001 belirlendi. Antioksidan düzeyinin değerlendirildiği total thiol P  ,002 ve native thiol P  ,001 değerlerinde anlamlı düşüşler, ve oksidasyonun değerlendirildiği disülfit düzeyinde anlamlı P  ,001 artış saptandı. CPVli köpeklerde klinik semptomların başlangıcından 24-48 saat önce alınan kan örneklerinde, CBC sayısında ve metabolik ve inflamasyon biyobelirteçlerinin düzeylerinde meydana gelen erken dönem değişikliklerin hastalığın şiddetine, uygulanacak tıbbi tedavilerin seçimine ve prognoza yön verebileceği sonucuna varıldı.

Makale detayları

Evaluation of CBC, Lipid Profile, Oxidative Stress Biomarkers, Total Thiol, Native Thiol, and Disulfide Levels in Dogs Diagnosed with Parvoviral Enteritis Without Clinical Findings

Yazarlar:

N.A.

Yayıncı:

Ataturk University

Ana Başlıklar:

Veteriner Bilimleri

Dergi:

Veterinary Sciences and Practices Vol.17 Issue 3, pp.98-102

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282151

pISSN:

2822-3608

Canine parvoviral enteritis

disulfide

MDA

PON-1

thiol

Canine parvoviral enteritis

disulfide

MDA

PON-1

thiol

Sayı

Makale detayları

Yazarlar: N.A.

Yayıncı: Ataturk University

Ana Başlıklar: Veteriner Bilimleri

Dergi: Veterinary Sciences and Practices Vol.17 Issue 3, pp.98-102

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001282151

pISSN: 2822-3608

Sayı

Yazarlar:

N.A.

Yayıncı:

Ataturk University

Ana Başlıklar:

Veteriner Bilimleri

Dergi:

Veterinary Sciences and Practices Vol.17 Issue 3, pp.98-102

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282151

pISSN:

2822-3608