Aerosolised hypertonic saline in hospitalized young children with acute bronchiolitis: a randomized controlled clinical trial.

K MAHESHKUMAR; B KARUNAKARA; Manjunath NAGALLİ; H MALLİKARJUNA

Makale detayları

Aerosolised hypertonic saline in hospitalized young children with acute bronchiolitis: a randomized controlled clinical trial.

Yazarlar:

K MAHESHKUMAR | B KARUNAKARA | Manjunath NAGALLİ | H MALLİKARJUNA

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2013 Vol.5 Issue 0

Belge Tipi:

Makale

Yayın Tarihi:

1/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000743403

Sıklık:

İki Yıllık

eISSN:

1309-1247

Özet:

 

ABSTRACT: 
Objectives: To determine the effectiveness of aerosolised 3% saline in hospitalised children with acute bronchiolitis.
Design:  Prospective, randomized, double blinded clinical study. 
Setting:  Referral teaching hospital, from October 2007 to March 2009. 
Patients: 40 children [age less than 2 yrs] were enrolled sequentially and randomized into 2 groups [20 each; Group- A - 3% saline and Group-B  [Normal saline]. 
Intervention: 4 nebulizations [3% saline or normal saline] were given every day until discharge. Additional inhalations were recorded as add-on nebulisations. Severity was assessed using the clinical severity score daily. Children showing worsening of clinical scores {treatment failure} were dropped from the study.
Principal outcome measures: Reduction in clinical severity & the length of hospital stay. Minor outcome measures studied were number of add-on nebulisations required & treatment failure. 
Results: The reduction in clinical severity scores was 1.8±0.83 in the 3% saline group and 1.7±0.86 in the normal saline group. The length of hospital stay was 2.25±0.89 days in 3% saline group compared to 2.88±1.76 days in the normal saline group. The number of add-on nebulisation was 2.4±4.1 in the normal saline group and 1.7±1.75 in the 3% saline group. These observations were not statistically significant. A significant difference was found in terms of treatment failures between the 2 groups [4 Vs 0] [p=0.03].
Conclusions: In hospitalized children with moderate acute bronchiolitis, aerosolized 3% saline is safe and prevented worsening of clinical symptoms but is not superior to normal saline in reducing the clinical severity and the length of hospital stay. 
Key words: hypertonic saline; viral bronchiolitis.
Abbreviations: NS- normal saline; 3S- 3% saline; LOS- length of hospital stay.

Makale detayları

Aerosolised hypertonic saline in hospitalized young children with acute bronchiolitis: a randomized controlled clinical trial.

Yazarlar: K MAHESHKUMAR | B KARUNAKARA | Manjunath NAGALLİ | H MALLİKARJUNA

Yayıncı: Bilal YILDIZ

Dergi: Journal of Pediatric Sciences 2013 Vol.5 Issue 0

Belge Tipi: Makale

Yayın Tarihi: 1/2013

Belge Dili: İngilizce

Document ID (Org No.): 2000743403

Sıklık: İki Yıllık

eISSN: 1309-1247

Sayı

Yazarlar:

K MAHESHKUMAR | B KARUNAKARA | Manjunath NAGALLİ | H MALLİKARJUNA

Yayıncı:

Bilal YILDIZ

Dergi:

Journal of Pediatric Sciences 2013 Vol.5 Issue 0

Belge Tipi:

Makale

Yayın Tarihi:

1/2013

Belge Dili:

İngilizce

Document ID (Org No.):

2000743403

Sıklık:

İki Yıllık

eISSN:

1309-1247