Some novel antimicrobial therapeutic agents for acetylcholinesterase inhibitors; synthesis of hydroxyquinoline ester involving amino acid

İffet ŞAKIYAN; Elif AYNACI; Fatma ARSLAN; Hatice ÖĞÜTCÜ; Nurşen SARI

Makale detayları

Some novel antimicrobial therapeutic agents for acetylcholinesterase inhibitors; synthesis of hydroxyquinoline ester involving amino acid

Yazarlar:

İffet ŞAKIYAN | Elif AYNACI | Fatma ARSLAN | Hatice ÖĞÜTCÜ | Nurşen SARI

Yayıncı:

Gazi University

Dergi:

Gazi University Journal of Science 2015 Vol.28 Issue 1, pp.11-19

Belge Tipi:

Makale

Yayın Tarihi:

2/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000428953

eISSN:

2147-1762

Özet:

 

The aim of this work was to investigate the new effective agents candidate for treatment of the Alzheimer’s disease. So, a series of new and highly active acetylcholinesterase inhibitors derived from hydroxyquinoline ester containing amino acid were synthesized. Antibacterial activities of the molecules were studied by the well-diffusion method against Listeria monocytogenes 4b, Staphylococcus aureus, Escherichia coli, Salmonella typhi H, Brucella abortus, Staphylococcus epidermis sp., Micrococcus luteus, Shigella dysenteria type 10, Bacillus cereus, Pseudomonas putida and antifungal activity against Candida albicans. All the synthesized compounds behave as inhibitors against AChE enzyme. CysEs and MetEs show more inhibition potency.

Makale detayları

Some novel antimicrobial therapeutic agents for acetylcholinesterase inhibitors; synthesis of hydroxyquinoline ester involving amino acid

Yazarlar: İffet ŞAKIYAN | Elif AYNACI | Fatma ARSLAN | Hatice ÖĞÜTCÜ | Nurşen SARI

Yayıncı: Gazi University

Dergi: Gazi University Journal of Science 2015 Vol.28 Issue 1, pp.11-19

Belge Tipi: Makale

Yayın Tarihi: 2/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000428953

eISSN: 2147-1762

Sayı

Yazarlar:

İffet ŞAKIYAN | Elif AYNACI | Fatma ARSLAN | Hatice ÖĞÜTCÜ | Nurşen SARI

Yayıncı:

Gazi University

Dergi:

Gazi University Journal of Science 2015 Vol.28 Issue 1, pp.11-19

Belge Tipi:

Makale

Yayın Tarihi:

2/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000428953

eISSN:

2147-1762