The effect of the antioxidant drug “U-74389G” on alkaline phosphatase levels during ischemia reperfusion injury in rats

Constantinos TSOMPOS; Constantinos PANOULİS; Konstantinos TOUTOUZAS; George ZOGRAFOS; Apostolos PAPALOİS

Makale detayları

The effect of the antioxidant drug “U-74389G” on alkaline phosphatase levels during ischemia reperfusion injury in rats

Yazarlar:

Constantinos TSOMPOS | Constantinos PANOULİS | Konstantinos TOUTOUZAS | George ZOGRAFOS | Apostolos PAPALOİS

Yayıncı:

Ondokuz Mayıs University

Dergi:

Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 2

Belge Tipi:

Makale

Yayın Tarihi:

9/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000508576

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483

Özet:

 


The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a liver ischemia reperfusion (IR) protocol. The beneficial effect or non effectiveness of that molecule were studied biochemically using mean blood alkaline phosphatase levels (ALP). Forty rats of mean weight 231.875 gr were used in the study. ALP levels were measured 60 min after reperfusion (groups A and C) and 120 min after reperfusion (groups B and D) with administration of the drug U-74389G in groups C and D. U-74389G administration non significantly increased the ALP levels by 19.76%±15.06% (p=0.1784), but by 31.91%±7.69% (p=0.0001) for predicted values. Reperfusion time non-significantly decreased the ALP levels by 25.21%±14.83% (p=0.0675), also by 6.38%±9.30% (p=0.3650) for predicted values. However, U-74389G administration and reperfusion time together non-significantly increased the ALP levels by 8.08%±9.19% (p=0.3696), but also by 17.75%±4.79% (p=0.0005) for predicted values. This study indicates that U-74389G administration and its interaction with reperfusion time non significantly increased short-term effects on ALP levels. However, the predicted ALP values adjusted for rats weight, kept significantly increased ones, which stand for the restorating effects of U-74389G, that are slower than it seems.

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Makale detayları

The effect of the antioxidant drug “U-74389G” on alkaline phosphatase levels during ischemia reperfusion injury in rats

Yazarlar: Constantinos TSOMPOS | Constantinos PANOULİS | Konstantinos TOUTOUZAS | George ZOGRAFOS | Apostolos PAPALOİS

Yayıncı: Ondokuz Mayıs University

Dergi: Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 2

Belge Tipi: Makale

Yayın Tarihi: 9/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000508576

Sıklık: Üç Aylık

eISSN: 1309-5129

pISSN: 1309-4483

Sayı

Yazarlar:

Constantinos TSOMPOS | Constantinos PANOULİS | Konstantinos TOUTOUZAS | George ZOGRAFOS | Apostolos PAPALOİS

Yayıncı:

Ondokuz Mayıs University

Dergi:

Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 2

Belge Tipi:

Makale

Yayın Tarihi:

9/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000508576

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483