Effects of Acute Grayanotoxin-I Administration  on Hepatic and Renal Functions in Rats

Meral AŞÇIOĞLU

Makale detayları

Effects of Acute Grayanotoxin-I Administration on Hepatic and Renal Functions in Rats

Yazarlar:

Meral AŞÇIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.23-28

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757730

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The effects of acute Grayanotoxin-I  (GTX-I) administration on hepatic and renal  functions in rats were investigated. GTX-I  was administrated to the animals of groups  1, 2 and 3 at a single i.p. dose of 1 mg/kg,  0.5 mg/kg and 0.25 mg/kg respectively, and  group 4 (control) received i.p. saline (0.9 %)  solution only. One hour following the  administration of GTX-I or saline, urine  analysis (leukocytes, urobilinogen, protein,  pH, blood, ketone, glucose, nitrites) was  performed and serum was evaluated for  activities of glutamic pyruvic transaminase  (GPT), g-glutamyl transferase (g-GT) and  isoenzymes of lactate dehydrogenase (LDH)  (as a percentage of total LDH activity),  transferrin, ceruloplasmin and total protein  concentrations and histopathologic changes  in the liver and kidney. A single dose of GTX-I  produced proteinuria and hematuria and  decreased GPT, LDH 3 , LDH 4 , and g -GT. But  the loss of GPT, LDH 3 and LDH4 partially  disguised by hepatic enzyme leakage which  was the result of hepatic damage occured  with increasing doses of GTX-I. Hepatic  damage was also detected by light  microscopy.

 

The effects of acute Grayanotoxin-I  (GTX-I) administration on hepatic and renal  functions in rats were investigated. GTX-I  was administrated to the animals of groups  1, 2 and 3 at a single i.p. dose of 1 mg/kg,  0.5 mg/kg and 0.25 mg/kg respectively, and  group 4 (control) received i.p. saline (0.9 %)  solution only. One hour following the  administration of GTX-I or saline, urine  analysis (leukocytes, urobilinogen, protein,  pH, blood, ketone, glucose, nitrites) was  performed and serum was evaluated for  activities of glutamic pyruvic transaminase  (GPT), g-glutamyl transferase (g-GT) and  isoenzymes of lactate dehydrogenase (LDH)  (as a percentage of total LDH activity),  transferrin, ceruloplasmin and total protein  concentrations and histopathologic changes  in the liver and kidney. A single dose of GTX-I  produced proteinuria and hematuria and  decreased GPT, LDH 3 , LDH 4 , and g -GT. But  the loss of GPT, LDH 3 and LDH4 partially  disguised by hepatic enzyme leakage which  was the result of hepatic damage occured  with increasing doses of GTX-I. Hepatic  damage was also detected by light  microscopy.

Makale detayları

Effects of Acute Grayanotoxin-I Administration on Hepatic and Renal Functions in Rats

Yazarlar:

Meral AŞÇIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.23-28

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757730

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Grayanotokxin

glutamic pyruvic transaminase (GPT)

g-glutamyl transferase (g -GT)

lactate deyhdrgenase (LDH)3 serum total protein.

Sayı

Makale detayları

Effects of Acute Grayanotoxin-I Administration on Hepatic and Renal Functions in Rats

Yazarlar: Meral AŞÇIOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.23-28

Belge Tipi: Makale

Yayın Tarihi: 12/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000757730

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Grayanotokxin

glutamic pyruvic transaminase (GPT)

g-glutamyl transferase (g -GT)

lactate deyhdrgenase (LDH)3 serum total protein.

Sayı

Yazarlar:

Meral AŞÇIOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 1, pp.23-28

Belge Tipi:

Makale

Yayın Tarihi:

12/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000757730

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144