Effect of Experimental Diabetes Mellitus on Plasma Lactate Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Rabbits

İsmail ÇELİK; Eşref YEĞİN

Makale detayları

Effect of Experimental Diabetes Mellitus on Plasma Lactate Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Rabbits

Yazarlar:

İsmail ÇELİK | Eşref YEĞİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2002 Vol.26 Issue 3, pp.151-154

Belge Tipi:

Makale

Yayın Tarihi:

2/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000813702

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

Hyperglycemia was induced in 20 male, white, New Zealand rabbits (2-3 kg) (Oryctolagus cuniculus huxley) by alloxan (100 mg/kg body weight, I.V.) and maintained for 16 weeks without insulin treatment. Blood samples were taken from both diabetic and non-diabetic rabbits at the same time for measurement of plasma enzymes. Levels of glutamic oxalacetic transaminase (GOT) and lactate dehydrogenase (LDH) were determined after treatment.  The levels of LDH and GOT were 155.6 ± 41.9 U/L and 47.0 ± 20.4 U/L in the control group respectively. These parameters were 286.9 ± 142.9 U/L and 93.9 ± 62.5 U/L in the diabetic group respectively. It was observed that LDH (p  0.05) in the diabetic group. In conclusion, we agree that routine use of LDH measurement to monitor diabetic status may be useful, but the characteristic parameters of diabetes mellitus are better indicators.

 

Hyperglycemia was induced in 20 male, white, New Zealand rabbits (2-3 kg) (Oryctolagus cuniculus huxley) by alloxan (100 mg/kg body weight, I.V.) and maintained for 16 weeks without insulin treatment. Blood samples were taken from both diabetic and non-diabetic rabbits at the same time for measurement of plasma enzymes. Levels of glutamic oxalacetic transaminase (GOT) and lactate dehydrogenase (LDH) were determined after treatment.  The levels of LDH and GOT were 155.6 ± 41.9 U/L and 47.0 ± 20.4 U/L in the control group respectively. These parameters were 286.9 ± 142.9 U/L and 93.9 ± 62.5 U/L in the diabetic group respectively. It was observed that LDH (p  0.05) in the diabetic group. In conclusion, we agree that routine use of LDH measurement to monitor diabetic status may be useful, but the characteristic parameters of diabetes mellitus are better indicators.

Makale detayları

Effect of Experimental Diabetes Mellitus on Plasma Lactate Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Rabbits

Yazarlar:

İsmail ÇELİK | Eşref YEĞİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2002 Vol.26 Issue 3, pp.151-154

Belge Tipi:

Makale

Yayın Tarihi:

2/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000813702

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Diabetes mellitus

LDH

GOT

Rabbit

Sayı

Makale detayları

Effect of Experimental Diabetes Mellitus on Plasma Lactate Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Rabbits

Yazarlar: İsmail ÇELİK | Eşref YEĞİN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2002 Vol.26 Issue 3, pp.151-154

Belge Tipi: Makale

Yayın Tarihi: 2/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000813702

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Diabetes mellitus

LDH

GOT

Rabbit

Sayı

Yazarlar:

İsmail ÇELİK | Eşref YEĞİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2002 Vol.26 Issue 3, pp.151-154

Belge Tipi:

Makale

Yayın Tarihi:

2/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000813702

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152