Evaluation of monocyte to high-density lipoprotein cholesterol ratio and other inflammatory markers in hidradenitis suppurativa: a case-control study

Zeynep Utlu; Saime Özbek Şebin; Nurcan Metin

Makale detayları

Evaluation of monocyte to high-density lipoprotein cholesterol ratio and other inflammatory markers in hidradenitis suppurativa: a case-control study

Yazarlar:

Zeynep Utlu | Saime Özbek Şebin | Nurcan Metin

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Dermatoloji

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 6, pp.1200-1204

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303034

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: Hidradenitis suppurativa HS is an inflammatory disease whose pathophysiology is not yet clearly known, but inflammatory parameters have been used for many years in the diagnosis and follow-up. The aim of this study is to evaluate NLR, PLR, MHR, and hemogram parameters in patients diagnosed with HS without comorbidities and compare them with healthy controls. Methods: This study include 105 HS patients and 100 healthy volunteers. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophils, lymphocytes, monocytes, platelets, mean platelet volume MPV, platelet distribution width PDW, red cell distribution width coefficient of variation RDW-CV, high-density lipoprotein cholesterol HDL-C, C-reactive protein CRP, Neutrophil-lymphocyte ratio NLR, monocyte-lymphocyte ratio MLR, platelet-lymphocyte ratio PLR, and MHR were compared. Results: A total of 105 patients 43 41 women and 62 59 men and one hundred healthy volunteers 52 52 women and 48 48 men participated in the study. The mean of neutrophil count patient group5.842.27, control group4.291.81, p0.001, lymphocyte count patient group2.780.90, control group2.310.63, p0.001, monocyte count patient group0.740.39, control group0.550.16, p0.001, platelet count patient group295.6365.84, control group274.4559.06, p0.007, CRP patient group12.7124.38, control group2.612.21, p0.039, and MHR patient group0.02030.0135, control group0.01140.0056, p0.001 were higher in the patient whereas the mean of HDL-C patient group39.0211.06, control group52.8516.46, p0.001 and PLR patient group118.8260.82, control group126.0739.13, p0.028 were significantly higher in control individuals. The adjusted effect of MHR, NLR, and PLR was re-examined to eliminate the effect that may arise from the difference in age between patients and controls. It was observed that when MHR increased by 0.01 unit, the risk of disease increased significantly by 4.07 times. When NLR increases by 1 unit, the disease increased. significantly by 1.37 times. Both adjusted and unadjusted effects of MHR were significant. When the sensitivity and specificity of MHR, and NLR in differentiating patients were examined, the sensitivity of MHR was found to be 67.4 and its specificity was 72.5 p0.001, while the sensitivity of NLR was found to be 61.5 and its specificity was 74.0  p0.038. Conclusions: Our study showed that MHR was more effective in distinguishing HS patients than other inflammatory markers. MHR can be used as a new marker to investigate the inflammatory effect of HS.

 Aims: Hidradenitis suppurativa HS is an inflammatory disease whose pathophysiology is not yet clearly known, but inflammatory parameters have been used for many years in the diagnosis and follow-up. The aim of this study is to evaluate NLR, PLR, MHR, and hemogram parameters in patients diagnosed with HS without comorbidities and compare them with healthy controls. Methods: This study include 105 HS patients and 100 healthy volunteers. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophils, lymphocytes, monocytes, platelets, mean platelet volume MPV, platelet distribution width PDW, red cell distribution width coefficient of variation RDW-CV, high-density lipoprotein cholesterol HDL-C, C-reactive protein CRP, Neutrophil-lymphocyte ratio NLR, monocyte-lymphocyte ratio MLR, platelet-lymphocyte ratio PLR, and MHR were compared. Results: A total of 105 patients 43 41 women and 62 59 men and one hundred healthy volunteers 52 52 women and 48 48 men participated in the study. The mean of neutrophil count patient group5.842.27, control group4.291.81, p0.001, lymphocyte count patient group2.780.90, control group2.310.63, p0.001, monocyte count patient group0.740.39, control group0.550.16, p0.001, platelet count patient group295.6365.84, control group274.4559.06, p0.007, CRP patient group12.7124.38, control group2.612.21, p0.039, and MHR patient group0.02030.0135, control group0.01140.0056, p0.001 were higher in the patient whereas the mean of HDL-C patient group39.0211.06, control group52.8516.46, p0.001 and PLR patient group118.8260.82, control group126.0739.13, p0.028 were significantly higher in control individuals. The adjusted effect of MHR, NLR, and PLR was re-examined to eliminate the effect that may arise from the difference in age between patients and controls. It was observed that when MHR increased by 0.01 unit, the risk of disease increased significantly by 4.07 times. When NLR increases by 1 unit, the disease increased. significantly by 1.37 times. Both adjusted and unadjusted effects of MHR were significant. When the sensitivity and specificity of MHR, and NLR in differentiating patients were examined, the sensitivity of MHR was found to be 67.4 and its specificity was 72.5 p0.001, while the sensitivity of NLR was found to be 61.5 and its specificity was 74.0  p0.038. Conclusions: Our study showed that MHR was more effective in distinguishing HS patients than other inflammatory markers. MHR can be used as a new marker to investigate the inflammatory effect of HS.

 Aims: Hidradenitis suppurativa HS is an inflammatory disease whose pathophysiology is not yet clearly known, but inflammatory parameters have been used for many years in the diagnosis and follow-up. The aim of this study is to evaluate NLR, PLR, MHR, and hemogram parameters in patients diagnosed with HS without comorbidities and compare them with healthy controls. Methods: This study include 105 HS patients and 100 healthy volunteers. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophils, lymphocytes, monocytes, platelets, mean platelet volume MPV, platelet distribution width PDW, red cell distribution width coefficient of variation RDW-CV, high-density lipoprotein cholesterol HDL-C, C-reactive protein CRP, Neutrophil-lymphocyte ratio NLR, monocyte-lymphocyte ratio MLR, platelet-lymphocyte ratio PLR, and MHR were compared. Results: A total of 105 patients 43 41 women and 62 59 men and one hundred healthy volunteers 52 52 women and 48 48 men participated in the study. The mean of neutrophil count patient group5.842.27, control group4.291.81, p0.001, lymphocyte count patient group2.780.90, control group2.310.63, p0.001, monocyte count patient group0.740.39, control group0.550.16, p0.001, platelet count patient group295.6365.84, control group274.4559.06, p0.007, CRP patient group12.7124.38, control group2.612.21, p0.039, and MHR patient group0.02030.0135, control group0.01140.0056, p0.001 were higher in the patient whereas the mean of HDL-C patient group39.0211.06, control group52.8516.46, p0.001 and PLR patient group118.8260.82, control group126.0739.13, p0.028 were significantly higher in control individuals. The adjusted effect of MHR, NLR, and PLR was re-examined to eliminate the effect that may arise from the difference in age between patients and controls. It was observed that when MHR increased by 0.01 unit, the risk of disease increased significantly by 4.07 times. When NLR increases by 1 unit, the disease increased. significantly by 1.37 times. Both adjusted and unadjusted effects of MHR were significant. When the sensitivity and specificity of MHR, and NLR in differentiating patients were examined, the sensitivity of MHR was found to be 67.4 and its specificity was 72.5 p0.001, while the sensitivity of NLR was found to be 61.5 and its specificity was 74.0  p0.038. Conclusions: Our study showed that MHR was more effective in distinguishing HS patients than other inflammatory markers. MHR can be used as a new marker to investigate the inflammatory effect of HS.

 Aims: Hidradenitis suppurativa HS is an inflammatory disease whose pathophysiology is not yet clearly known, but inflammatory parameters have been used for many years in the diagnosis and follow-up. The aim of this study is to evaluate NLR, PLR, MHR, and hemogram parameters in patients diagnosed with HS without comorbidities and compare them with healthy controls. Methods: This study include 105 HS patients and 100 healthy volunteers. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophils, lymphocytes, monocytes, platelets, mean platelet volume MPV, platelet distribution width PDW, red cell distribution width coefficient of variation RDW-CV, high-density lipoprotein cholesterol HDL-C, C-reactive protein CRP, Neutrophil-lymphocyte ratio NLR, monocyte-lymphocyte ratio MLR, platelet-lymphocyte ratio PLR, and MHR were compared. Results: A total of 105 patients 43 41 women and 62 59 men and one hundred healthy volunteers 52 52 women and 48 48 men participated in the study. The mean of neutrophil count patient group5.842.27, control group4.291.81, p0.001, lymphocyte count patient group2.780.90, control group2.310.63, p0.001, monocyte count patient group0.740.39, control group0.550.16, p0.001, platelet count patient group295.6365.84, control group274.4559.06, p0.007, CRP patient group12.7124.38, control group2.612.21, p0.039, and MHR patient group0.02030.0135, control group0.01140.0056, p0.001 were higher in the patient whereas the mean of HDL-C patient group39.0211.06, control group52.8516.46, p0.001 and PLR patient group118.8260.82, control group126.0739.13, p0.028 were significantly higher in control individuals. The adjusted effect of MHR, NLR, and PLR was re-examined to eliminate the effect that may arise from the difference in age between patients and controls. It was observed that when MHR increased by 0.01 unit, the risk of disease increased significantly by 4.07 times. When NLR increases by 1 unit, the disease increased. significantly by 1.37 times. Both adjusted and unadjusted effects of MHR were significant. When the sensitivity and specificity of MHR, and NLR in differentiating patients were examined, the sensitivity of MHR was found to be 67.4 and its specificity was 72.5 p0.001, while the sensitivity of NLR was found to be 61.5 and its specificity was 74.0  p0.038. Conclusions: Our study showed that MHR was more effective in distinguishing HS patients than other inflammatory markers. MHR can be used as a new marker to investigate the inflammatory effect of HS.

Makale detayları

Evaluation of monocyte to high-density lipoprotein cholesterol ratio and other inflammatory markers in hidradenitis suppurativa: a case-control study

Yazarlar:

Zeynep Utlu | Saime Özbek Şebin | Nurcan Metin

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Dermatoloji

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 6, pp.1200-1204

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303034

pISSN:

2636-8579

Hidradenitis Suppurativa

Hematologic Tests

Monocytes

Cholesterol HDL

Sayı

Makale detayları

Evaluation of monocyte to high-density lipoprotein cholesterol ratio and other inflammatory markers in hidradenitis suppurativa: a case-control study

Yazarlar: Zeynep Utlu | Saime Özbek Şebin | Nurcan Metin

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Dermatoloji

Dergi: Journal of Health Sciences and Medicine Vol.6 Issue 6, pp.1200-1204

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001303034

pISSN: 2636-8579

Hidradenitis Suppurativa

Hematologic Tests

Monocytes

Cholesterol HDL

Sayı

Yazarlar:

Zeynep Utlu | Saime Özbek Şebin | Nurcan Metin

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Dermatoloji

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 6, pp.1200-1204

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303034

pISSN:

2636-8579