Reactivation of Epstein–Barr virus in Aplastic Anemia: A clinical challenge

Nilesh WASEKAR; Girish BADARKHE; Samadhan PAWAR; Chaitanya BORDE; Yasam Venkata RAMESH; Raj NAGARKAR

Makale detayları

Reactivation of Epstein–Barr virus in Aplastic Anemia: A clinical challenge

Yazarlar:

Nilesh WASEKAR | Girish BADARKHE | Samadhan PAWAR | Chaitanya BORDE | Yasam Venkata RAMESH | Raj NAGARKAR

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Experimental and Clinical Medicine 2020 Vol.37 Issue 4, pp.143-147

Belge Tipi:

Makale

Yayın Tarihi:

9/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000507750

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483

Özet:

 

Background: Acquired aplastic anemia is an unusual disease associated with pancytopenia characterized by hypocellular bone marrow. Aplastic anemia is an auto-immune disorder wherein patients would show a antithymocyte globulin (ATG)- induced hematological response after T-cell reduction. The combination of cyclosporine A and ATG as immunosuppressive therapy is considered as the standard treatment approach for patients with aplastic anemia. EBV infection in a patient with aplastic anemia is an unusual clinical presentation.
Case Report: A 49-year-old Asian female presented to our hospital with dizziness and fatigue. The patient’s platelet count was extremely low. A hypocellular marrow with lymphocytosis was observed with the help of a bone marrow aspirate and biopsy. The patient was given cyclosporine and eltrombopag as a bridge to primary therapy, i.e. antithymocyte globulin (ATG)/allogenic transplant considering she had pancytopenia. The patient developed platelet refractoriness. Epstein-Barr virus polymerase chain reaction (PCR) was performed, considering the patient’s atypical presentation. As per the results, it was significantly positive with 2250 copies/ul. A diagnosis of aplastic anemia with EBV infection was made.

Makale detayları

Reactivation of Epstein–Barr virus in Aplastic Anemia: A clinical challenge

Yazarlar: Nilesh WASEKAR | Girish BADARKHE | Samadhan PAWAR | Chaitanya BORDE | Yasam Venkata RAMESH | Raj NAGARKAR

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Experimental and Clinical Medicine 2020 Vol.37 Issue 4, pp.143-147

Belge Tipi: Makale

Yayın Tarihi: 9/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000507750

Sıklık: Üç Aylık

eISSN: 1309-5129

pISSN: 1309-4483

Sayı

Yazarlar:

Nilesh WASEKAR | Girish BADARKHE | Samadhan PAWAR | Chaitanya BORDE | Yasam Venkata RAMESH | Raj NAGARKAR

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Experimental and Clinical Medicine 2020 Vol.37 Issue 4, pp.143-147

Belge Tipi:

Makale

Yayın Tarihi:

9/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000507750

Sıklık:

Üç Aylık

eISSN:

1309-5129

pISSN:

1309-4483