Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmunodeficiency?

Recep Evcen; Fatih Çölkesen; Filiz Sadi Aykan; Mehmet Kılınç; Eray Yıldız; Ümmügülsüm Yılmaz Ergün; Tuğba Önalan; Fatma Arzu Akkuş; Selim Kahraman; Mehmet Emin Gerek; Şevket Arslan

Makale detayları

Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmunodeficiency?

Yazarlar:

Recep Evcen | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Eray Yıldız | Ümmügülsüm Yılmaz Ergün | Tuğba Önalan | Fatma Arzu Akkuş | Selim Kahraman | Mehmet Emin Gerek | Şevket Arslan

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

İç Hastalıkları | Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 4, pp.480-486

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290348

pISSN:

1305-4953

Anahtar kelimeler:

Özet:

 Common variable immunodeficiency CVID is the most common symptomatic immunodeficiency in adults. This study assessed the utility of using the C-reactive protein CRPalbumin ratio CAR at diagnosis to predict mortality in CVID patients. Between 2010 and 2022, hospital records and follow-up cards of patients with CVID were reviewed retrospectively. Seventy-five patients were included in the study. CRP 05 mgL and albumin 3.55.5 gdL were taken as references. The CAR was obtained by dividing the CRP value by the albumin value. Of the included patients, 41 55 were male and 34 35 were female. The median age was 38 2177 years. The mortality rate of the patients during the follow-up time was 20. Of the patients, 41 had splenomegaly, 10.6 had malignancy, and 39 had bronchiectasis. The cut-off value of CAR to predict mortality was 2.18 sensitivity: 88.4, specificity: 90.1. When the patients were classified according to the CAR, the mortality rate in the patient group with a CAR  2.18 was statistically significantly higher than the patient group with a CAR  2.18. The CAR is a cheap, simple, and easily calculated parameter that can predict mortality in CVID patients.

 Common variable immunodeficiency CVID is the most common symptomatic immunodeficiency in adults. This study assessed the utility of using the C-reactive protein CRPalbumin ratio CAR at diagnosis to predict mortality in CVID patients. Between 2010 and 2022, hospital records and follow-up cards of patients with CVID were reviewed retrospectively. Seventy-five patients were included in the study. CRP 05 mgL and albumin 3.55.5 gdL were taken as references. The CAR was obtained by dividing the CRP value by the albumin value. Of the included patients, 41 55 were male and 34 35 were female. The median age was 38 2177 years. The mortality rate of the patients during the follow-up time was 20. Of the patients, 41 had splenomegaly, 10.6 had malignancy, and 39 had bronchiectasis. The cut-off value of CAR to predict mortality was 2.18 sensitivity: 88.4, specificity: 90.1. When the patients were classified according to the CAR, the mortality rate in the patient group with a CAR  2.18 was statistically significantly higher than the patient group with a CAR  2.18. The CAR is a cheap, simple, and easily calculated parameter that can predict mortality in CVID patients.

 Common variable immunodeficiency CVID is the most common symptomatic immunodeficiency in adults. This study assessed the utility of using the C-reactive protein CRPalbumin ratio CAR at diagnosis to predict mortality in CVID patients. Between 2010 and 2022, hospital records and follow-up cards of patients with CVID were reviewed retrospectively. Seventy-five patients were included in the study. CRP 05 mgL and albumin 3.55.5 gdL were taken as references. The CAR was obtained by dividing the CRP value by the albumin value. Of the included patients, 41 55 were male and 34 35 were female. The median age was 38 2177 years. The mortality rate of the patients during the follow-up time was 20. Of the patients, 41 had splenomegaly, 10.6 had malignancy, and 39 had bronchiectasis. The cut-off value of CAR to predict mortality was 2.18 sensitivity: 88.4, specificity: 90.1. When the patients were classified according to the CAR, the mortality rate in the patient group with a CAR  2.18 was statistically significantly higher than the patient group with a CAR  2.18. The CAR is a cheap, simple, and easily calculated parameter that can predict mortality in CVID patients.

 Yaygın değişken immün yetersizlik YDİY, yetişkinlerde en sık görülen semptomatik primer immün yetmezliktir. Bu çalışma, CVID hastalarında mortaliteyi tahmin etmek için tanıda C-reaktif protein CRPalbümin oranı CAO kullanmanın faydasını değerlendirdi. 2010-2022 yılları arasında YDİYli hastaların hastane kayıtları ve takip kartları retrospektif olarak incelendi. Çalışmaya yetmiş beş hasta dahil edildi. CRP 05 mgL ve albümin 3,55,5 gdL referans olarak alındı. CAO, CRP değerinin albümin değerine bölünmesiyle elde edildi. Çalışmaya alınan hastaların 41i 55 erkek, 34ü 35 kadındı. Ortanca yaş 38 21-77 idi. Takip süresi boyunca hastaların ölüm oranı 20 idi. Hastaların 41inde splenomegali, 10.6sında malignite ve 39unda bronşektazi vardı. CAOnın mortaliteyi öngörmek için kesme değeri 2,18 idi duyarlılık: 88,4, özgüllük: 90,1. Hastalar CAO göre sınıflandırıldığında, CAO  2,18 olan hasta grubunda mortalite oranı, CAO  2,18 olan hasta grubuna göre istatistiksel olarak anlamlı derecede yüksekti. CAO, YDİY hastalarda mortaliteyi tahmin edebilen ucuz, basit ve kolayca hesaplanabilen bir parametredir.

Makale detayları

Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmunodeficiency?

Yazarlar:

Recep Evcen | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Eray Yıldız | Ümmügülsüm Yılmaz Ergün | Tuğba Önalan | Fatma Arzu Akkuş | Selim Kahraman | Mehmet Emin Gerek | Şevket Arslan

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

İç Hastalıkları | Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 4, pp.480-486

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290348

pISSN:

1305-4953

Common Variable Immune Deficiency

Albumin

CRPYaygın değişken immün yetmezlik

Albumin

CRP

Sayı

Makale detayları

Could the C-reactive protein/albumin Ratio Predict Mortality in Patients with Common Variable İmmunodeficiency?

Yazarlar: Recep Evcen | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Eray Yıldız | Ümmügülsüm Yılmaz Ergün | Tuğba Önalan | Fatma Arzu Akkuş | Selim Kahraman | Mehmet Emin Gerek | Şevket Arslan

Yayıncı: Eskişehir Osmangazi University

Ana Başlıklar: İç Hastalıkları | Sağlık Kurumları Yönetimi

Dergi: Osmangazi Tıp Dergisi Vol.45 Issue 4, pp.480-486

Belge Tipi: Makale

Yayın Tarihi: 7/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001290348

pISSN: 1305-4953

Common Variable Immune Deficiency

Albumin

CRPYaygın değişken immün yetmezlik

Albumin

CRP

Sayı

Yazarlar:

Recep Evcen | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Eray Yıldız | Ümmügülsüm Yılmaz Ergün | Tuğba Önalan | Fatma Arzu Akkuş | Selim Kahraman | Mehmet Emin Gerek | Şevket Arslan

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

İç Hastalıkları | Sağlık Kurumları Yönetimi

Dergi:

Osmangazi Tıp Dergisi Vol.45 Issue 4, pp.480-486

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001290348

pISSN:

1305-4953