Genetic association analysis of ERBB4 polymorphisms with the risk of  schizophrenia susceptibility in a Jordanian population of Arab descent

Laith ALEITAN; Sahar AL-HABAHBEH; Rami ALKHATIB

Makale detayları

Genetic association analysis of ERBB4 polymorphisms with the risk of schizophrenia susceptibility in a Jordanian population of Arab descent

Yazarlar:

Laith ALEITAN | Sahar AL-HABAHBEH | Rami ALKHATIB

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.542-553

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751444

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The ERBB4 gene encodes a transmembrane tyrosine kinase and is considered to be one of the risk genes of  schizophrenia. Although there is evidence of the roles of genes and the environment in the etiology of schizophrenia, a comprehensive  biological and genetic background of the disease is still lacking. The aim of this study is to assess whether genetic variation in the human  ERBB4 gene is associated with vulnerability to schizophrenia in the Jordanian Arab population.  Materials and methods: A total of 185 inpatients with schizophrenia participated in this study and 195 healthy genetically homogeneous  individuals were also used as controls. Two genetic variants, rs839523 (G/A, intron 2) and rs3748962 (A/G, exon 27), encompassing the  ERBB4 gene were genotyped using DNA sequencing.  Results: The results revealed a strong and statistically significant genetic association of rs839523 with schizophrenia (P = 0.002 for allele  and P = 0.006 for genotype).  Conclusion: This study provides strong statistical evidence that there is an association between the ERBB4 gene and schizophrenia in a  Jordanian population of Arab descent.

Makale detayları

Genetic association analysis of ERBB4 polymorphisms with the risk of schizophrenia susceptibility in a Jordanian population of Arab descent

Yazarlar: Laith ALEITAN | Sahar AL-HABAHBEH | Rami ALKHATIB

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.542-553

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751444

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Laith ALEITAN | Sahar AL-HABAHBEH | Rami ALKHATIB

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.542-553

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751444

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144