Antioxidant and Anti-inflammatory Activity of Five Centaurea Species

Ali Şen

Makale detayları

Antioxidant and Anti-inflammatory Activity of Five Centaurea Species

Yazarlar:

Ali Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

European Journal of Biology Vol.82 Issue 2, pp.311-316

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310879

pISSN:

2602-2575

Anahtar kelimeler:

Özet:

 Objective: In this study, we examined the anti-inflammatory and antioxidant ABTS radical scavenging activity of methanol extracts of aerial parts except capitula and capitula of Centaurea cuneifolia, C. iberica, C. kilaea, C. solstitialis subsp. solstitialis and C. stenolepis for the first time comparatively. Materials and Methods: The antioxidant and anti-inflammatory activity, expressed as IC50 values, were determined by 2, 2- Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic asit ABTS and 5-lipoxygenase methods. The total phenolic content, expressed as gallic acid equivalents, was estimated by Folin-Ciocalteu method. Results: Methanol extract of capitula of C. solstitialis subsp. solstitialis CSSC with an IC50 value of 8.74 µgmL showed antioxidant activity as strong as standard acarbose 4.41 µgmL against ABTS radicals. The IC50 values of ABTS radical scavenging activities of other extracts varied between 24.42 and 88.95 µgmL. CSSC with an IC50 value of 122.10 µgmL displayed moderate inhibitory activity against 5-lipoxygenase enzyme. The IC50 values of the antilipoxygenase activities of the other extracts were found to vary between 122.10 and 781.30 µgmL. Also, the highest amount of total phenolic compounds was found in the CSSC 83.41 mgg, while the lowest was found in methanol extract of aerial parts of C. solstitialis subsp. solstitialis 35.20 mgg. Conclusion: These results clearly indicate that CSSC has significant antioxidant and anti-inflammatory activity. As far as is known, this paper is the first comparative study on ABTS radical scavenging and lipoxygenase inhibitory activity of five different Centaurea species. It is also the first study on the antilipoxygenase activity of C. iberica and C. solstitialis subsp. solstitialis.

 Objective: In this study, we examined the anti-inflammatory and antioxidant ABTS radical scavenging activity of methanol extracts of aerial parts except capitula and capitula of Centaurea cuneifolia, C. iberica, C. kilaea, C. solstitialis subsp. solstitialis and C. stenolepis for the first time comparatively. Materials and Methods: The antioxidant and anti-inflammatory activity, expressed as IC50 values, were determined by 2, 2- Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic asit ABTS and 5-lipoxygenase methods. The total phenolic content, expressed as gallic acid equivalents, was estimated by Folin-Ciocalteu method. Results: Methanol extract of capitula of C. solstitialis subsp. solstitialis CSSC with an IC50 value of 8.74 µgmL showed antioxidant activity as strong as standard acarbose 4.41 µgmL against ABTS radicals. The IC50 values of ABTS radical scavenging activities of other extracts varied between 24.42 and 88.95 µgmL. CSSC with an IC50 value of 122.10 µgmL displayed moderate inhibitory activity against 5-lipoxygenase enzyme. The IC50 values of the antilipoxygenase activities of the other extracts were found to vary between 122.10 and 781.30 µgmL. Also, the highest amount of total phenolic compounds was found in the CSSC 83.41 mgg, while the lowest was found in methanol extract of aerial parts of C. solstitialis subsp. solstitialis 35.20 mgg. Conclusion: These results clearly indicate that CSSC has significant antioxidant and anti-inflammatory activity. As far as is known, this paper is the first comparative study on ABTS radical scavenging and lipoxygenase inhibitory activity of five different Centaurea species. It is also the first study on the antilipoxygenase activity of C. iberica and C. solstitialis subsp. solstitialis.

 Objective: In this study, we examined the anti-inflammatory and antioxidant ABTS radical scavenging activity of methanol extracts of aerial parts except capitula and capitula of Centaurea cuneifolia, C. iberica, C. kilaea, C. solstitialis subsp. solstitialis and C. stenolepis for the first time comparatively. Materials and Methods: The antioxidant and anti-inflammatory activity, expressed as IC50 values, were determined by 2, 2- Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic asit ABTS and 5-lipoxygenase methods. The total phenolic content, expressed as gallic acid equivalents, was estimated by Folin-Ciocalteu method. Results: Methanol extract of capitula of C. solstitialis subsp. solstitialis CSSC with an IC50 value of 8.74 µgmL showed antioxidant activity as strong as standard acarbose 4.41 µgmL against ABTS radicals. The IC50 values of ABTS radical scavenging activities of other extracts varied between 24.42 and 88.95 µgmL. CSSC with an IC50 value of 122.10 µgmL displayed moderate inhibitory activity against 5-lipoxygenase enzyme. The IC50 values of the antilipoxygenase activities of the other extracts were found to vary between 122.10 and 781.30 µgmL. Also, the highest amount of total phenolic compounds was found in the CSSC 83.41 mgg, while the lowest was found in methanol extract of aerial parts of C. solstitialis subsp. solstitialis 35.20 mgg. Conclusion: These results clearly indicate that CSSC has significant antioxidant and anti-inflammatory activity. As far as is known, this paper is the first comparative study on ABTS radical scavenging and lipoxygenase inhibitory activity of five different Centaurea species. It is also the first study on the antilipoxygenase activity of C. iberica and C. solstitialis subsp. solstitialis.

 Objective: In this study, we examined the anti-inflammatory and antioxidant ABTS radical scavenging activity of methanol extracts of aerial parts except capitula and capitula of Centaurea cuneifolia, C. iberica, C. kilaea, C. solstitialis subsp. solstitialis and C. stenolepis for the first time comparatively. Materials and Methods: The antioxidant and anti-inflammatory activity, expressed as IC50 values, were determined by 2, 2- Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic asit ABTS and 5-lipoxygenase methods. The total phenolic content, expressed as gallic acid equivalents, was estimated by Folin-Ciocalteu method. Results: Methanol extract of capitula of C. solstitialis subsp. solstitialis CSSC with an IC50 value of 8.74 µgmL showed antioxidant activity as strong as standard acarbose 4.41 µgmL against ABTS radicals. The IC50 values of ABTS radical scavenging activities of other extracts varied between 24.42 and 88.95 µgmL. CSSC with an IC50 value of 122.10 µgmL displayed moderate inhibitory activity against 5-lipoxygenase enzyme. The IC50 values of the antilipoxygenase activities of the other extracts were found to vary between 122.10 and 781.30 µgmL. Also, the highest amount of total phenolic compounds was found in the CSSC 83.41 mgg, while the lowest was found in methanol extract of aerial parts of C. solstitialis subsp. solstitialis 35.20 mgg. Conclusion: These results clearly indicate that CSSC has significant antioxidant and anti-inflammatory activity. As far as is known, this paper is the first comparative study on ABTS radical scavenging and lipoxygenase inhibitory activity of five different Centaurea species. It is also the first study on the antilipoxygenase activity of C. iberica and C. solstitialis subsp. solstitialis.

Makale detayları

Antioxidant and Anti-inflammatory Activity of Five Centaurea Species

Yazarlar: Ali Şen

Yayıncı: Istanbul University

Ana Başlıklar: Biochemistry and Cell Biology (Other)

Dergi: European Journal of Biology Vol.82 Issue 2, pp.311-316

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001310879

pISSN: 2602-2575

Centaurea species

antioxidant activity

anti-inflammatory activity

total phenolic content

Sayı

Yazarlar:

Ali Şen

Yayıncı:

Istanbul University

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

European Journal of Biology Vol.82 Issue 2, pp.311-316

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310879

pISSN:

2602-2575