The role of fine-needle aspiration biopsy in the diagnosis of salivary gland lesions: a comparative histopathological study

Selma Şengiz Erhan; Çağlar Çakır; Pınar Özay Nayır; Elis Kangal; Serkan Arıbal; Ziya Salturk

Makale detayları

The role of fine-needle aspiration biopsy in the diagnosis of salivary gland lesions: a comparative histopathological study

Yazarlar:

Selma Şengiz Erhan | Çağlar Çakır | Pınar Özay Nayır | Elis Kangal | Serkan Arıbal | Ziya Salturk

Yayıncı:

Ataturk University

Ana Başlıklar:

Cerrahi

Dergi:

Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi Vol.2 Issue 2, pp.78-84

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297752

pISSN:

2822-3519

Anahtar kelimeler:

Özet:

 Objective: As the treatment of neoplastic and non-neoplastic lesions of salivary gland differs, their differentiation in preoperative period is crucial. Fine-needle aspiration biopsy FNAB is among the common diagnostic methods for this purpose. We intended to compare the cytological-histopathological diagnosis of salivary gland lesions, and evaluate sensitivity, specificity, predictive value PV and diagnostic accuracy of the FNAB results. Methods: 156 cases examined in our department, having FNAB and excision material, were compared with their cytological-histopathological diagnosis. Results: Lesions were localized in parotid gland in 132 cases, in submandibular gland in 22 cases, and in minor salivary gland in 2 cases. FNABs were categorized based on their cytomorphological results into nondiagnostic 7.05, benign 78.21, suspicious 7.05 and malignant 7.69 groups. When the cytological-histopathological diagnosis of cases was compared, the diagnosis of 12 cases among malignant lesions 100, 1212 and 121 among benign lesions 99.2, 121122 were found to be compatible. One false negative case 0.8 warthin tumormucoepidermoid carcinoma was detected, but no false positive 0 was the case. Histopathological examinations of three cases among suspicious lesions resulted in diagnosis of ectopic thyroid tissue, sialadenitis and pleomorphic adenoma. Results of sensitivity, specificity, positive PV, negative PV and accuracy analysis examinations were respectively 92.3, 100, 100, 99.2 and 99.3. Conclusion: Evaluating FNABs with sufficient sampling minimizes false positivenegative results, leading to accurate diagnosis in preoperative period. Wide range of salivary gland lesions and overlapping cytomorphological findings should also be minded.

 Objective: As the treatment of neoplastic and non-neoplastic lesions of salivary gland differs, their differentiation in preoperative period is crucial. Fine-needle aspiration biopsy FNAB is among the common diagnostic methods for this purpose. We intended to compare the cytological-histopathological diagnosis of salivary gland lesions, and evaluate sensitivity, specificity, predictive value PV and diagnostic accuracy of the FNAB results. Methods: 156 cases examined in our department, having FNAB and excision material, were compared with their cytological-histopathological diagnosis. Results: Lesions were localized in parotid gland in 132 cases, in submandibular gland in 22 cases, and in minor salivary gland in 2 cases. FNABs were categorized based on their cytomorphological results into nondiagnostic 7.05, benign 78.21, suspicious 7.05 and malignant 7.69 groups. When the cytological-histopathological diagnosis of cases was compared, the diagnosis of 12 cases among malignant lesions 100, 1212 and 121 among benign lesions 99.2, 121122 were found to be compatible. One false negative case 0.8 warthin tumormucoepidermoid carcinoma was detected, but no false positive 0 was the case. Histopathological examinations of three cases among suspicious lesions resulted in diagnosis of ectopic thyroid tissue, sialadenitis and pleomorphic adenoma. Results of sensitivity, specificity, positive PV, negative PV and accuracy analysis examinations were respectively 92.3, 100, 100, 99.2 and 99.3. Conclusion: Evaluating FNABs with sufficient sampling minimizes false positivenegative results, leading to accurate diagnosis in preoperative period. Wide range of salivary gland lesions and overlapping cytomorphological findings should also be minded.

 Objective: As the treatment of neoplastic and non-neoplastic lesions of salivary gland differs, their differentiation in preoperative period is crucial. Fine-needle aspiration biopsy FNAB is among the common diagnostic methods for this purpose. We intended to compare the cytological-histopathological diagnosis of salivary gland lesions, and evaluate sensitivity, specificity, predictive value PV and diagnostic accuracy of the FNAB results. Methods: 156 cases examined in our department, having FNAB and excision material, were compared with their cytological-histopathological diagnosis. Results: Lesions were localized in parotid gland in 132 cases, in submandibular gland in 22 cases, and in minor salivary gland in 2 cases. FNABs were categorized based on their cytomorphological results into nondiagnostic 7.05, benign 78.21, suspicious 7.05 and malignant 7.69 groups. When the cytological-histopathological diagnosis of cases was compared, the diagnosis of 12 cases among malignant lesions 100, 1212 and 121 among benign lesions 99.2, 121122 were found to be compatible. One false negative case 0.8 warthin tumormucoepidermoid carcinoma was detected, but no false positive 0 was the case. Histopathological examinations of three cases among suspicious lesions resulted in diagnosis of ectopic thyroid tissue, sialadenitis and pleomorphic adenoma. Results of sensitivity, specificity, positive PV, negative PV and accuracy analysis examinations were respectively 92.3, 100, 100, 99.2 and 99.3. Conclusion: Evaluating FNABs with sufficient sampling minimizes false positivenegative results, leading to accurate diagnosis in preoperative period. Wide range of salivary gland lesions and overlapping cytomorphological findings should also be minded.

 Amaç: Tükürük bezi non-neoplastik ve neoplastik lezyonlarının tedavileri farklılık gösterdiği için, preoperatif dönemde ayrımlarının yapılması önemlidir. İnce iğne aspirasyon biyopsisi İİAB bu amaçla en yaygın kullanılan tanı yöntemlerinden biridir. Burada tükürük bezi lezyonlarının sitolojik-histopatolojik tanılarının karşılaştırılması, İİAB sonuçlarının sensitivite, spesifite, prediktif değer PV ve tanısal doğruluğunun değerlendirilmesi amaçlandı. Materyal ve metod: Bölümümüzde incelenen İİAB ve eksizyon materyali olan 156 olgu sitolojik-histopatolojik tanıları ile karşılaştırıldı. Bulgular: Lezyonlar 132 84.6 olguda parotis bezinde, 22 14.1 olguda submandibuler bezde ve 2 1.3 olguda minör tükürük bezinde lokalizeydi. İİABlerin sitomorfolojik sonuçlarına göre  7.05i n11 nondiagnostik, 78.21i n122 benign,  7.05i n11 kuşkulu ve  7.69u n12 malign olarak sınıflandırıldı. Olguların sitolojik-histopatolojik tanıları karşılaştırıldığında; malign lezyonlar içinde 12 olgunun 1212; 100 ve benign lezyonlar içinde 121 olgunun 121122; 99.2 tanıları uyumluydu. False negatif bir olgu 0.8 warthin tümörmukoepidermoid karsinom saptandı. False pozitif olgu saptanmadı 0. Kuşkulu lezyonlar içinde üç olgunun histopatolojik incelemeleri ektopik tiroid dokusu, sialadenit ve pleomorfik adenom tanıları ile sonuçlandı. Sensitivite, spesifite, pozitif PV, negatif PV ve doğruluk analizi değerlendirmesinde sırasıyla  92.3,  100.0,  100.0,  99.2 ve  99.3 sonuçları elde edildi. Sonuç: İİABlerinde yeterli örnekleme ile birlikte değerlendirmelerindeki deneyim, çalışmamızda olduğu gibi false pozitifnegatif sonuçları en aza indirgeyecek ve preoperatif dönemde doğru tanıya ulaştıracaktır. Bununla birlikte tükürük bezi lezyonlarının geniş yelpazesi ve örtüşebilecek sitomorfolojik bulguların varlığı da akılda tutulmalıdır.

Makale detayları

The role of fine-needle aspiration biopsy in the diagnosis of salivary gland lesions: a comparative histopathological study

Yazarlar:

Selma Şengiz Erhan | Çağlar Çakır | Pınar Özay Nayır | Elis Kangal | Serkan Arıbal | Ziya Salturk

Yayıncı:

Ataturk University

Ana Başlıklar:

Cerrahi

Dergi:

Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi Vol.2 Issue 2, pp.78-84

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297752

pISSN:

2822-3519

Salivary gland

fine-needle aspiration biopsy

pleomorphic adenoma

mucoepidermoid carcinomaTükürük bezi

ince iğne aspirasyon biyopsisi

pleomorfik adenom

mukoepidermoid karsinom

Sayı

Makale detayları

Yazarlar: Selma Şengiz Erhan | Çağlar Çakır | Pınar Özay Nayır | Elis Kangal | Serkan Arıbal | Ziya Salturk

Yayıncı: Ataturk University

Ana Başlıklar: Cerrahi

Dergi: Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi Vol.2 Issue 2, pp.78-84

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001297752

pISSN: 2822-3519

Sayı

Yazarlar:

Selma Şengiz Erhan | Çağlar Çakır | Pınar Özay Nayır | Elis Kangal | Serkan Arıbal | Ziya Salturk

Yayıncı:

Ataturk University

Ana Başlıklar:

Cerrahi

Dergi:

Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi Vol.2 Issue 2, pp.78-84

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001297752

pISSN:

2822-3519