Impact of obesity and prognostic nutritional index on outcomes of ventricular tachycardia ablation in patients with structural heart disease

Emir Baskovski; Ömer Akyürek; Timucin Altin; Mahmut Ekrem Cunetoglu

Makale detayları

Impact of obesity and prognostic nutritional index on outcomes of ventricular tachycardia ablation in patients with structural heart disease

Yazarlar:

Emir Baskovski | Ömer Akyürek | Timucin Altin | Mahmut Ekrem Cunetoglu

Yayıncı:

Ankara University

Ana Başlıklar:

Cardiology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.217-225

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358153

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: Previous studies have demonstrated that nutritional disorders such as obesity and malnutrition are associated with adverse events in patients with a structural heart disease. The impact of these conditions in patients undergoing ventricular tachycardia VT ablation is not known. In this study we sought to investigate the effect of obesity and malnutrition on procedural and post-procedural midterm outcomes in patients undergoing VT ablation. Materials and methods: This is a single center, retrospective study which enrolled patients undergoing structural VT ablation. Patients were classified as normal weight, overweight and obese by body mass index BMI. Malnutrition was defined as prognostic nutritional score PNI  38. Outcomes between groups were compared. Results: A total of 203 patients were enrolled to this study. Among these patients, 54 25.6 were normal weight, 102 patients 50.2 were overweight, and 47 patients 23.1 were obese. 18 patients 8.8 were classified as malnourished. No significant difference in VT recurrence was observed across BMI p0.335 or nutritional status p0.556. However, mortality during follow-up was significantly higher in the malnourished group 50 vs. 7, p0.001, while BMI showed no significant association with mortality p0.202. On multivariate analysis, only PNI 38 HR 6.659, 95 CI 2.55317.369, p0.001 and electrical storm HR 2.848, 95 CI 1.1337.160, p0.026 remained independent predictors of mortality. Conclusion: This study demonstrated that malnourished patients, as classified by PNI, had significantly worse acute success and higher long-term mortality with similar VT recurrence rate, compared to non-malnourished patients. Obesity status, as defined by BMI, did not lead to different outcomes.

 Objectives: Previous studies have demonstrated that nutritional disorders such as obesity and malnutrition are associated with adverse events in patients with a structural heart disease. The impact of these conditions in patients undergoing ventricular tachycardia VT ablation is not known. In this study we sought to investigate the effect of obesity and malnutrition on procedural and post-procedural midterm outcomes in patients undergoing VT ablation. Materials and methods: This is a single center, retrospective study which enrolled patients undergoing structural VT ablation. Patients were classified as normal weight, overweight and obese by body mass index BMI. Malnutrition was defined as prognostic nutritional score PNI  38. Outcomes between groups were compared. Results: A total of 203 patients were enrolled to this study. Among these patients, 54 25.6 were normal weight, 102 patients 50.2 were overweight, and 47 patients 23.1 were obese. 18 patients 8.8 were classified as malnourished. No significant difference in VT recurrence was observed across BMI p0.335 or nutritional status p0.556. However, mortality during follow-up was significantly higher in the malnourished group 50 vs. 7, p0.001, while BMI showed no significant association with mortality p0.202. On multivariate analysis, only PNI 38 HR 6.659, 95 CI 2.55317.369, p0.001 and electrical storm HR 2.848, 95 CI 1.1337.160, p0.026 remained independent predictors of mortality. Conclusion: This study demonstrated that malnourished patients, as classified by PNI, had significantly worse acute success and higher long-term mortality with similar VT recurrence rate, compared to non-malnourished patients. Obesity status, as defined by BMI, did not lead to different outcomes.

 Objectives: Previous studies have demonstrated that nutritional disorders such as obesity and malnutrition are associated with adverse events in patients with a structural heart disease. The impact of these conditions in patients undergoing ventricular tachycardia VT ablation is not known. In this study we sought to investigate the effect of obesity and malnutrition on procedural and post-procedural midterm outcomes in patients undergoing VT ablation. Materials and methods: This is a single center, retrospective study which enrolled patients undergoing structural VT ablation. Patients were classified as normal weight, overweight and obese by body mass index BMI. Malnutrition was defined as prognostic nutritional score PNI  38. Outcomes between groups were compared. Results: A total of 203 patients were enrolled to this study. Among these patients, 54 25.6 were normal weight, 102 patients 50.2 were overweight, and 47 patients 23.1 were obese. 18 patients 8.8 were classified as malnourished. No significant difference in VT recurrence was observed across BMI p0.335 or nutritional status p0.556. However, mortality during follow-up was significantly higher in the malnourished group 50 vs. 7, p0.001, while BMI showed no significant association with mortality p0.202. On multivariate analysis, only PNI 38 HR 6.659, 95 CI 2.55317.369, p0.001 and electrical storm HR 2.848, 95 CI 1.1337.160, p0.026 remained independent predictors of mortality. Conclusion: This study demonstrated that malnourished patients, as classified by PNI, had significantly worse acute success and higher long-term mortality with similar VT recurrence rate, compared to non-malnourished patients. Obesity status, as defined by BMI, did not lead to different outcomes.

 Amaç: Önceki çalışmalar, obezite ve malnütrisyon gibi beslenme bozukluklarının yapısal kalp hastalığı olan hastalarda olumsuz sonuçlarla ilişkili olduğunu göstermiştir. Bu durumların ventriküler taşikardi VT ablasyonu geçiren hastalardaki etkisi ise bilinmemektedir. Bu çalışmada, VT ablasyonu geçiren hastalarda obezite ve malnütrisyonun işlem sırasındaki ve işlem sonrası orta vadeli sonuçlar üzerindeki etkisini araştırmayı amaçladık. Gereç ve yöntem: Bu tek merkezli, retrospektif çalışmaya yapısal VT ablasyonu uygulanan hastalar dahil edilmiştir. Hastalar beden kitle indeksi BKİ kullanılarak normal kilolu, fazla kilolu ve obez olarak sınıflandırılmıştır. Malnütrisyon, prognostik beslenme indeksi PNI  38 olarak tanımlanmıştır. Gruplar arasındaki sonuçlar karşılaştırılmıştır. Bulgular: Çalışmaya toplam 203 hasta dahil edilmiştir. Bu hastaların 54ü 25,6 normal kilolu, 102si 50,2 fazla kilolu ve 47si 23,1 obez olarak sınıflandırılmıştır. Öte yandan, 18 hasta 8,8 malnütrisyonlu olarak tanımlanmıştır. BKİ p0,335 veya beslenme durumu p0,556 ile VT nüksü arasında anlamlı bir ilişki gözlemlenmemiştir. Ancak takip sürecinde mortalite, malnütrisyonlu grupta anlamlı şekilde daha yüksek bulunmuştur 50 ve 7, p0,001; buna karşın BKİ ile mortalite arasında anlamlı bir ilişki saptanmamıştır p0,202. Çok değişkenli analizde, yalnızca PNI 38 HR 6,659, 95 GA 2,55317,369, p0,001 ve elektriksel fırtına HR 2,848, 95 GA 1,1337,160, p0,026 mortalitenin bağımsız belirleyicileri olduğu saptanmıştır. Sonuç: Bu çalışma, PNI ile malnütrisyonlu olarak sınıflandırılan hastaların, malnütrisyonlu olmayan hastalara kıyasla benzer VT nüks oranına rağmen anlamlı şekilde daha düşük akut başarı ve daha yüksek uzun vadeli mortaliteye sahip olduğunu göstermiştir. BKİ ile tanımlanan obezite durumu ise sonlanım noktalarında farklılığa yol açmamıştır.

Makale detayları

Impact of obesity and prognostic nutritional index on outcomes of ventricular tachycardia ablation in patients with structural heart disease

Yazarlar:

Emir Baskovski | Ömer Akyürek | Timucin Altin | Mahmut Ekrem Cunetoglu

Yayıncı:

Ankara University

Ana Başlıklar:

Cardiology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.217-225

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358153

pISSN:

0365-8104

catheter ablation

heart failure

malnutrition

obesity

ventricular tachycardiakateter ablasyon

kalp yetersizliği

malnutrisyon

obezite

ventriküler taşikardi

Sayı

Makale detayları

Yazarlar: Emir Baskovski | Ömer Akyürek | Timucin Altin | Mahmut Ekrem Cunetoglu

Yayıncı: Ankara University

Ana Başlıklar: Cardiology

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.217-225

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001358153

pISSN: 0365-8104

Sayı

Yazarlar:

Emir Baskovski | Ömer Akyürek | Timucin Altin | Mahmut Ekrem Cunetoglu

Yayıncı:

Ankara University

Ana Başlıklar:

Cardiology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.78 Issue 3, pp.217-225

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001358153

pISSN:

0365-8104