Formulation and pharmacokinetic evaluation of rifampicin solid lipid nanoparticles

N.A.

Makale detayları

Formulation and pharmacokinetic evaluation of rifampicin solid lipid nanoparticles

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 4, pp.539-551

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347941

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 This study aims to optimize RIF loaded solid lipid nanoparticles RIF-SLNs to sustain its release and enhance its oral absorption and bioavailability. RIF loaded SLNs were formulated by a modified micro emulsionbased technique using two different lipids Cetyl palmitate and Glyceryl monostearate and two different surfactants Tween80 and Poloxamer 188. Particle size, polydispersity index PDI, zeta potential, entrapment efficiency E.E, drug loading capacity L.C, in vitro drug release, differential scanning calorimetry DSC, Fourier transform infrared spectroscopy FTIR and transmission electron microscopy TEM were determined for RIF loaded SLNs formulae. Pharmacokinetic study was performed on optimized RIF-SLNs, marketed RIF and pure drug suspension in Wistar rats. The particle size, PDI, E.E and L.C of optimized formula were recorded as 0.183 µm, 0.420, -34.7 mV, 80.8 and 0.216, respectively. In vitro release studies suggested that all SLNs formulae possessed a burst release created from the unloaded drug and adsorbed drug molecules at SLNs surface then sustained release due to diffusion of drug from lipid matrix over a period of 120 h. From the release kinetics data, the release rate of RIF from all formulae fitted into Higuchis diffusion model. Pharmacokinetic study showed significant enhancement in RIF-SLNs relative bioavailability 5.86 and 2.33 folds in comparison with pure RIF suspension and marketed RIF. RIF loaded SLNs were formulated successfully by a modified micro emulsion-based method. Also, oral drug delivery can be enhanced by SLNs which showed improvement in the oral bioavailability of the drug.

 This study aims to optimize RIF loaded solid lipid nanoparticles RIF-SLNs to sustain its release and enhance its oral absorption and bioavailability. RIF loaded SLNs were formulated by a modified micro emulsionbased technique using two different lipids Cetyl palmitate and Glyceryl monostearate and two different surfactants Tween80 and Poloxamer 188. Particle size, polydispersity index PDI, zeta potential, entrapment efficiency E.E, drug loading capacity L.C, in vitro drug release, differential scanning calorimetry DSC, Fourier transform infrared spectroscopy FTIR and transmission electron microscopy TEM were determined for RIF loaded SLNs formulae. Pharmacokinetic study was performed on optimized RIF-SLNs, marketed RIF and pure drug suspension in Wistar rats. The particle size, PDI, E.E and L.C of optimized formula were recorded as 0.183 µm, 0.420, -34.7 mV, 80.8 and 0.216, respectively. In vitro release studies suggested that all SLNs formulae possessed a burst release created from the unloaded drug and adsorbed drug molecules at SLNs surface then sustained release due to diffusion of drug from lipid matrix over a period of 120 h. From the release kinetics data, the release rate of RIF from all formulae fitted into Higuchis diffusion model. Pharmacokinetic study showed significant enhancement in RIF-SLNs relative bioavailability 5.86 and 2.33 folds in comparison with pure RIF suspension and marketed RIF. RIF loaded SLNs were formulated successfully by a modified micro emulsion-based method. Also, oral drug delivery can be enhanced by SLNs which showed improvement in the oral bioavailability of the drug.

 This study aims to optimize RIF loaded solid lipid nanoparticles RIF-SLNs to sustain its release and enhance its oral absorption and bioavailability. RIF loaded SLNs were formulated by a modified micro emulsionbased technique using two different lipids Cetyl palmitate and Glyceryl monostearate and two different surfactants Tween80 and Poloxamer 188. Particle size, polydispersity index PDI, zeta potential, entrapment efficiency E.E, drug loading capacity L.C, in vitro drug release, differential scanning calorimetry DSC, Fourier transform infrared spectroscopy FTIR and transmission electron microscopy TEM were determined for RIF loaded SLNs formulae. Pharmacokinetic study was performed on optimized RIF-SLNs, marketed RIF and pure drug suspension in Wistar rats. The particle size, PDI, E.E and L.C of optimized formula were recorded as 0.183 µm, 0.420, -34.7 mV, 80.8 and 0.216, respectively. In vitro release studies suggested that all SLNs formulae possessed a burst release created from the unloaded drug and adsorbed drug molecules at SLNs surface then sustained release due to diffusion of drug from lipid matrix over a period of 120 h. From the release kinetics data, the release rate of RIF from all formulae fitted into Higuchis diffusion model. Pharmacokinetic study showed significant enhancement in RIF-SLNs relative bioavailability 5.86 and 2.33 folds in comparison with pure RIF suspension and marketed RIF. RIF loaded SLNs were formulated successfully by a modified micro emulsion-based method. Also, oral drug delivery can be enhanced by SLNs which showed improvement in the oral bioavailability of the drug.

 This study aims to optimize RIF loaded solid lipid nanoparticles RIF-SLNs to sustain its release and enhance its oral absorption and bioavailability. RIF loaded SLNs were formulated by a modified micro emulsionbased technique using two different lipids Cetyl palmitate and Glyceryl monostearate and two different surfactants Tween80 and Poloxamer 188. Particle size, polydispersity index PDI, zeta potential, entrapment efficiency E.E, drug loading capacity L.C, in vitro drug release, differential scanning calorimetry DSC, Fourier transform infrared spectroscopy FTIR and transmission electron microscopy TEM were determined for RIF loaded SLNs formulae. Pharmacokinetic study was performed on optimized RIF-SLNs, marketed RIF and pure drug suspension in Wistar rats. The particle size, PDI, E.E and L.C of optimized formula were recorded as 0.183 µm, 0.420, -34.7 mV, 80.8 and 0.216, respectively. In vitro release studies suggested that all SLNs formulae possessed a burst release created from the unloaded drug and adsorbed drug molecules at SLNs surface then sustained release due to diffusion of drug from lipid matrix over a period of 120 h. From the release kinetics data, the release rate of RIF from all formulae fitted into Higuchis diffusion model. Pharmacokinetic study showed significant enhancement in RIF-SLNs relative bioavailability 5.86 and 2.33 folds in comparison with pure RIF suspension and marketed RIF. RIF loaded SLNs were formulated successfully by a modified micro emulsion-based method. Also, oral drug delivery can be enhanced by SLNs which showed improvement in the oral bioavailability of the drug.

Makale detayları

Formulation and pharmacokinetic evaluation of rifampicin solid lipid nanoparticles

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 4, pp.539-551

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347941

pISSN:

2630-6344

: Pharmacokinetic enhancement

rifampicin

In vitro release

solid lipid nanoparticles

glyceryl monostearate

cetyl palmitate

Sayı

Makale detayları

Formulation and pharmacokinetic evaluation of rifampicin solid lipid nanoparticles

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 4, pp.539-551

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347941

pISSN: 2630-6344

: Pharmacokinetic enhancement

rifampicin

In vitro release

solid lipid nanoparticles

glyceryl monostearate

cetyl palmitate

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 4, pp.539-551

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347941

pISSN:

2630-6344