Screening of Inhibitory Effects Lanosterol on Butyrylcholinesterase, Acetylcholinesterase and Carbonic Anhydrase Enzymes

Eda Mehtap Üç

Makale detayları

Screening of Inhibitory Effects Lanosterol on Butyrylcholinesterase, Acetylcholinesterase and Carbonic Anhydrase Enzymes

Yazarlar:

Eda Mehtap Üç

Yayıncı:

Igdir University

Ana Başlıklar:

Tıbbi ve Biyomoleküler Kimya (Diğer)

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2838-2846

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302950

pISSN:

2536-4618

Anahtar kelimeler:

Özet:

 In this study, for the first time, the antiglaucoma and anticholinergic properties from lanosterol were appraised and researched using different bioanalytical methods and compared with standards. Lanosterol is the compound from which entire fungal and animal steroids are derived. Moreover, is a tetracyclic triterpenoid. Lanosterol is a component in over-the-counter ophthalmic products to prohibit cataracts. The inhibition effects of lanosterol were tested against the butyrylcholinesterase BChE, carbonic anhydrase I and II CA I and II and acetylcholinesterase AChE, which are associated with some global diseases like Alzheimers disease AD and glaucoma. Lanosterol were trialed for the inhibition of BChE, AChE, hCA I and II enzymes and indicated efficient inhibition profiles with Ki values in the range of 61.7722.32 nM against hCA I, 101.1149.74 nM against hCA II, 2.031.21 nM against acetylcholinesterase and 8.392.92 nM against butyrylcholinesterase.

 In this study, for the first time, the antiglaucoma and anticholinergic properties from lanosterol were appraised and researched using different bioanalytical methods and compared with standards. Lanosterol is the compound from which entire fungal and animal steroids are derived. Moreover, is a tetracyclic triterpenoid. Lanosterol is a component in over-the-counter ophthalmic products to prohibit cataracts. The inhibition effects of lanosterol were tested against the butyrylcholinesterase BChE, carbonic anhydrase I and II CA I and II and acetylcholinesterase AChE, which are associated with some global diseases like Alzheimers disease AD and glaucoma. Lanosterol were trialed for the inhibition of BChE, AChE, hCA I and II enzymes and indicated efficient inhibition profiles with Ki values in the range of 61.7722.32 nM against hCA I, 101.1149.74 nM against hCA II, 2.031.21 nM against acetylcholinesterase and 8.392.92 nM against butyrylcholinesterase.

 In this study, for the first time, the antiglaucoma and anticholinergic properties from lanosterol were appraised and researched using different bioanalytical methods and compared with standards. Lanosterol is the compound from which entire fungal and animal steroids are derived. Moreover, is a tetracyclic triterpenoid. Lanosterol is a component in over-the-counter ophthalmic products to prohibit cataracts. The inhibition effects of lanosterol were tested against the butyrylcholinesterase BChE, carbonic anhydrase I and II CA I and II and acetylcholinesterase AChE, which are associated with some global diseases like Alzheimers disease AD and glaucoma. Lanosterol were trialed for the inhibition of BChE, AChE, hCA I and II enzymes and indicated efficient inhibition profiles with Ki values in the range of 61.7722.32 nM against hCA I, 101.1149.74 nM against hCA II, 2.031.21 nM against acetylcholinesterase and 8.392.92 nM against butyrylcholinesterase.

 In this study, for the first time, the antiglaucoma and anticholinergic properties from lanosterol were appraised and researched using different bioanalytical methods and compared with standards. Lanosterol is the compound from which entire fungal and animal steroids are derived. Moreover, is a tetracyclic triterpenoid. Lanosterol is a component in over-the-counter ophthalmic products to prohibit cataracts. The inhibition effects of lanosterol were tested against the butyrylcholinesterase BChE, carbonic anhydrase I and II CA I and II and acetylcholinesterase AChE, which are associated with some global diseases like Alzheimers disease AD and glaucoma. Lanosterol were trialed for the inhibition of BChE, AChE, hCA I and II enzymes and indicated efficient inhibition profiles with Ki values in the range of 61.7722.32 nM against hCA I, 101.1149.74 nM against hCA II, 2.031.21 nM against acetylcholinesterase and 8.392.92 nM against butyrylcholinesterase.

Makale detayları

Screening of Inhibitory Effects Lanosterol on Butyrylcholinesterase, Acetylcholinesterase and Carbonic Anhydrase Enzymes

Yazarlar:

Eda Mehtap Üç

Yayıncı:

Igdir University

Ana Başlıklar:

Tıbbi ve Biyomoleküler Kimya (Diğer)

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2838-2846

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302950

pISSN:

2536-4618

Lanosterol

Inhibition

CA I-II isoenzymes

Acetylcholinesterase

Butyrylcholinesterase

Sayı

Makale detayları

Screening of Inhibitory Effects Lanosterol on Butyrylcholinesterase, Acetylcholinesterase and Carbonic Anhydrase Enzymes

Yazarlar: Eda Mehtap Üç

Yayıncı: Igdir University

Ana Başlıklar: Tıbbi ve Biyomoleküler Kimya (Diğer)

Dergi: Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2838-2846

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001302950

pISSN: 2536-4618

Lanosterol

Inhibition

CA I-II isoenzymes

Acetylcholinesterase

Butyrylcholinesterase

Sayı

Yazarlar:

Eda Mehtap Üç

Yayıncı:

Igdir University

Ana Başlıklar:

Tıbbi ve Biyomoleküler Kimya (Diğer)

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.13 Issue 4, pp.2838-2846

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302950

pISSN:

2536-4618