Synthesis of New Anthraquinone Derivatives and Anticancer Effects on Breast Cancer Cell Lines

Ebru HACIOSMANOGLU; Funda OZKOK; Alper Kemal ONSU; Muhammet BEKTAS; Basak VAROL; Sacide PEHLIVAN

Makale detayları

Synthesis of New Anthraquinone Derivatives and Anticancer Effects on Breast Cancer Cell Lines

Yazarlar:

Ebru HACIOSMANOGLU | Funda OZKOK | Alper Kemal ONSU | Muhammet BEKTAS | Basak VAROL | Sacide PEHLIVAN

Dergi:

The Eurasia Proceedings of Science Technology Engineering and Mathematics 2018 Issue 4, pp.271-276

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000660976

Özet:

 


Antraquinone
and their analogues are among the important compounds investigated to develop
novel bioactive and biocompatible molecules with potential for medical
applications. The most important quinone class as anthraquinones occur widely
in plants such as aloe vera and tipton's weed. Anthraquinone derivatives have
aroused special interest since they have demonstrated potential therapeutic
uses as antibacterial, antiviral, antifungal agents and other biological
activities. Mitoxantrone, an anthraquinone analogue, is known as a synthetic
anticancer analog of anthracycline antibiotics. Mitoxantrone as anticancer drug
is a powerful inhibitor of the enzyme that is in charge with the repair of
damaged DNA. In this study, new anthraquinone derivatives([1-(4-Chlorothiophenyl)-9,10-dioxoanthraquinone],[1-(4-Aminothiophenyl)-9,10
dioxoanthraquinone]) were characterized by spectroscopic methods (1H-NMR,
13C-NMR, FT-IR, UV-Vis analyzes). Breast cancer cell lines (MDA- MB-231 and
MCF-7) and human umbilical vein endothelial cells (HUVECs) were proliferated in standard culture conditions. Cells were incubated
with these derivatives for 24 and 48 h with in different concentrations. Cell
proliferation assays, MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium
Bromide) and CCK-8 (Cell Counting Kit-8), were performed to reveal anticancer
effect of new anthraquinone derivatives. As a result, Cell viability of MDA-
MB-231 and MCF-7 cells were decreased significantly (p<0.05) by new
anthraquinone derivatives treatment whereas cytotoxic effect was not observed
in HUVECs. In this study new synthesized anthraquinone derivatives were tested
and comparable results were observed both in vitro cytotoxicity assay and
statistical analysis. This anthraquinone derivatives are promising for its
further development as an anticancer drug.

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Makale detayları

Synthesis of New Anthraquinone Derivatives and Anticancer Effects on Breast Cancer Cell Lines

Yazarlar: Ebru HACIOSMANOGLU | Funda OZKOK | Alper Kemal ONSU | Muhammet BEKTAS | Basak VAROL | Sacide PEHLIVAN

Dergi: The Eurasia Proceedings of Science Technology Engineering and Mathematics 2018 Issue 4, pp.271-276

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000660976

Sayı

Yazarlar:

Ebru HACIOSMANOGLU | Funda OZKOK | Alper Kemal ONSU | Muhammet BEKTAS | Basak VAROL | Sacide PEHLIVAN

Dergi:

The Eurasia Proceedings of Science Technology Engineering and Mathematics 2018 Issue 4, pp.271-276

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000660976