Evaluation of optic nerve by histogram analysis on MRI in patients with isolated optic neuritis

Seda Nida Karaküçük; Adil Doğan; Murat Baykara; Selma Urfalıoglu

Makale detayları

Evaluation of optic nerve by histogram analysis on MRI in patients with isolated optic neuritis

Yazarlar:

Seda Nida Karaküçük | Adil Doğan | Murat Baykara | Selma Urfalıoglu

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Radiology and Organ Imaging

Dergi:

The European Research Journal Vol.9 Issue 2, pp.285-290

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282990

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: We aimed to evaluate the Magnetic Resonance Imaging MRI histogram texture analyzis of the optic nerve by comparing patients of isolated optic neuritis with a healthy control group and to provide objective information without using contrast in the diagnosis of the disease. Methods: A total of 40 patients, including 20 patients with isolated optic neuritis 13 females, 7 males and 20 healthy controls 11 females, 9 males, were included in the study. Non-contrast brain MR images of the patient and control groups were analyzed retrospectively. In the coronal T2-weighted MRI sequence of both groups, the Region of Interest ROI was placed in the extraocular anterior 13 of the optic nerve of both eyes. Numerical data were obtained using histogram analysis and the data were evaluated in the MATLAB program. The data were compared statistically. In addition, sensitivity and specificity were determined by Receiver Operating Characteristic ROC curve analysis. Results: As a result of histogram analysis, a significant difference was found between the mean values in the healthy and affected eye of the patients with isolated optic neuritis and the mean values of the control group  p  0.05. A significant difference was found in standard deviation, minimum, maximum, median, variance values between both groups. ROC analysis was performed for mean value, AUC  0.943 and when threshold value was selected as 354.258 Haunsfield Unit, two groups could be differentiated with 84.2 of sensitivity and 92.1 of specificity. We can say that patients with isolated optic neuritis also have histological effects on the clinically asymptomatic eye. Conclusions: Histogram analysis can be used in the diagnosis of the patients with isolated optic neuritis without the need to use contrast in their MRI. In addition, histological effect can be detected in the eye that does not show clinical symptoms with histogram analysis.

 Objectives: We aimed to evaluate the Magnetic Resonance Imaging MRI histogram texture analyzis of the optic nerve by comparing patients of isolated optic neuritis with a healthy control group and to provide objective information without using contrast in the diagnosis of the disease. Methods: A total of 40 patients, including 20 patients with isolated optic neuritis 13 females, 7 males and 20 healthy controls 11 females, 9 males, were included in the study. Non-contrast brain MR images of the patient and control groups were analyzed retrospectively. In the coronal T2-weighted MRI sequence of both groups, the Region of Interest ROI was placed in the extraocular anterior 13 of the optic nerve of both eyes. Numerical data were obtained using histogram analysis and the data were evaluated in the MATLAB program. The data were compared statistically. In addition, sensitivity and specificity were determined by Receiver Operating Characteristic ROC curve analysis. Results: As a result of histogram analysis, a significant difference was found between the mean values in the healthy and affected eye of the patients with isolated optic neuritis and the mean values of the control group  p  0.05. A significant difference was found in standard deviation, minimum, maximum, median, variance values between both groups. ROC analysis was performed for mean value, AUC  0.943 and when threshold value was selected as 354.258 Haunsfield Unit, two groups could be differentiated with 84.2 of sensitivity and 92.1 of specificity. We can say that patients with isolated optic neuritis also have histological effects on the clinically asymptomatic eye. Conclusions: Histogram analysis can be used in the diagnosis of the patients with isolated optic neuritis without the need to use contrast in their MRI. In addition, histological effect can be detected in the eye that does not show clinical symptoms with histogram analysis.

 Objectives: We aimed to evaluate the Magnetic Resonance Imaging MRI histogram texture analyzis of the optic nerve by comparing patients of isolated optic neuritis with a healthy control group and to provide objective information without using contrast in the diagnosis of the disease. Methods: A total of 40 patients, including 20 patients with isolated optic neuritis 13 females, 7 males and 20 healthy controls 11 females, 9 males, were included in the study. Non-contrast brain MR images of the patient and control groups were analyzed retrospectively. In the coronal T2-weighted MRI sequence of both groups, the Region of Interest ROI was placed in the extraocular anterior 13 of the optic nerve of both eyes. Numerical data were obtained using histogram analysis and the data were evaluated in the MATLAB program. The data were compared statistically. In addition, sensitivity and specificity were determined by Receiver Operating Characteristic ROC curve analysis. Results: As a result of histogram analysis, a significant difference was found between the mean values in the healthy and affected eye of the patients with isolated optic neuritis and the mean values of the control group  p  0.05. A significant difference was found in standard deviation, minimum, maximum, median, variance values between both groups. ROC analysis was performed for mean value, AUC  0.943 and when threshold value was selected as 354.258 Haunsfield Unit, two groups could be differentiated with 84.2 of sensitivity and 92.1 of specificity. We can say that patients with isolated optic neuritis also have histological effects on the clinically asymptomatic eye. Conclusions: Histogram analysis can be used in the diagnosis of the patients with isolated optic neuritis without the need to use contrast in their MRI. In addition, histological effect can be detected in the eye that does not show clinical symptoms with histogram analysis.

 Objectives: We aimed to evaluate the Magnetic Resonance Imaging MRI histogram texture analyzis of the optic nerve by comparing patients of isolated optic neuritis with a healthy control group and to provide objective information without using contrast in the diagnosis of the disease. Methods: A total of 40 patients, including 20 patients with isolated optic neuritis 13 females, 7 males and 20 healthy controls 11 females, 9 males, were included in the study. Non-contrast brain MR images of the patient and control groups were analyzed retrospectively. In the coronal T2-weighted MRI sequence of both groups, the Region of Interest ROI was placed in the extraocular anterior 13 of the optic nerve of both eyes. Numerical data were obtained using histogram analysis and the data were evaluated in the MATLAB program. The data were compared statistically. In addition, sensitivity and specificity were determined by Receiver Operating Characteristic ROC curve analysis. Results: As a result of histogram analysis, a significant difference was found between the mean values in the healthy and affected eye of the patients with isolated optic neuritis and the mean values of the control group  p  0.05. A significant difference was found in standard deviation, minimum, maximum, median, variance values between both groups. ROC analysis was performed for mean value, AUC  0.943 and when threshold value was selected as 354.258 Haunsfield Unit, two groups could be differentiated with 84.2 of sensitivity and 92.1 of specificity. We can say that patients with isolated optic neuritis also have histological effects on the clinically asymptomatic eye. Conclusions: Histogram analysis can be used in the diagnosis of the patients with isolated optic neuritis without the need to use contrast in their MRI. In addition, histological effect can be detected in the eye that does not show clinical symptoms with histogram analysis.

Makale detayları

Evaluation of optic nerve by histogram analysis on MRI in patients with isolated optic neuritis

Yazarlar:

Seda Nida Karaküçük | Adil Doğan | Murat Baykara | Selma Urfalıoglu

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Radiology and Organ Imaging

Dergi:

The European Research Journal Vol.9 Issue 2, pp.285-290

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282990

pISSN:

2149-3189

Optic neuritis

histogram analysis

texture analysis

Sayı

Makale detayları

Evaluation of optic nerve by histogram analysis on MRI in patients with isolated optic neuritis

Yazarlar: Seda Nida Karaküçük | Adil Doğan | Murat Baykara | Selma Urfalıoglu

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Radiology and Organ Imaging

Dergi: The European Research Journal Vol.9 Issue 2, pp.285-290

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001282990

pISSN: 2149-3189

Optic neuritis

histogram analysis

texture analysis

Sayı

Yazarlar:

Seda Nida Karaküçük | Adil Doğan | Murat Baykara | Selma Urfalıoglu

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Radiology and Organ Imaging

Dergi:

The European Research Journal Vol.9 Issue 2, pp.285-290

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282990

pISSN:

2149-3189