Nitric Oxide in Chronic Liver Disease

Güldal KIRKALI

Makale detayları

Nitric Oxide in Chronic Liver Disease

Yazarlar:

Güldal KIRKALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.511-515

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757449

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The formation of nitric oxide  (NO), a free radical, increases in liver  disease, where the L-arginine-nitric oxide (L-  arg-NO) pathway is activated by the increased  levels of cytokines and endotoxins. In this  study, we investigated the relationship  between the L-arg-NO pathway and chronic  active hepatitis and cirrhosis, which are  classified as chronic liver disease. We  determined the serum levels of nitrite and  nitrate, the end products of the L-arg-NO  pathway, in patients with chronic liver  disease and compared them with the control  group levels.  Total nitrite produced by the reduction of  nitrate to nitrite in the presence of nitrate  reductase was determined. The measurement  of nitrite concentrations was based on the  Griess reaction. The nitrate concentrations  were obtained by subtracting the nitrite  concentrations from the total nitrite+nitrate  concentration.  The study group consisted of 21 patients  with chronic active hepatitis and 19 patients  with cirrhosis. In the cirrhosis group, serum  levels of nitrite+nitrate, nitrate and nitrite  were 84.8±9.43 mmol/L, 74.75±9.49  mmol/L and 10.03±1.59 mmol/L,  respectively. In the chronic active hepatitis  group, the values were 72.79±6.9 mmol/L,  59.9±7.09 mmol/L and 12.88±1.65 mmol/L,  respectively. The control group values  obtained from 10 normal persons were  29.0±4.6 mmol/L, 19.41± 3.16 mmol/L and  9.59±1.60 mmol/L, respectively.  The statistical evaluation showed a significant  difference between the control and study  groups (p 0.5).  Our results show that serum nitrite and  nitrate concentrations as an index of NO  generation may be elevated in hepatic failure  seen in chronic liver disease.

 

The formation of nitric oxide  (NO), a free radical, increases in liver  disease, where the L-arginine-nitric oxide (L-  arg-NO) pathway is activated by the increased  levels of cytokines and endotoxins. In this  study, we investigated the relationship  between the L-arg-NO pathway and chronic  active hepatitis and cirrhosis, which are  classified as chronic liver disease. We  determined the serum levels of nitrite and  nitrate, the end products of the L-arg-NO  pathway, in patients with chronic liver  disease and compared them with the control  group levels.  Total nitrite produced by the reduction of  nitrate to nitrite in the presence of nitrate  reductase was determined. The measurement  of nitrite concentrations was based on the  Griess reaction. The nitrate concentrations  were obtained by subtracting the nitrite  concentrations from the total nitrite+nitrate  concentration.  The study group consisted of 21 patients  with chronic active hepatitis and 19 patients  with cirrhosis. In the cirrhosis group, serum  levels of nitrite+nitrate, nitrate and nitrite  were 84.8±9.43 mmol/L, 74.75±9.49  mmol/L and 10.03±1.59 mmol/L,  respectively. In the chronic active hepatitis  group, the values were 72.79±6.9 mmol/L,  59.9±7.09 mmol/L and 12.88±1.65 mmol/L,  respectively. The control group values  obtained from 10 normal persons were  29.0±4.6 mmol/L, 19.41± 3.16 mmol/L and  9.59±1.60 mmol/L, respectively.  The statistical evaluation showed a significant  difference between the control and study  groups (p 0.5).  Our results show that serum nitrite and  nitrate concentrations as an index of NO  generation may be elevated in hepatic failure  seen in chronic liver disease.

Makale detayları

Nitric Oxide in Chronic Liver Disease

Yazarlar:

Güldal KIRKALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.511-515

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757449

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Nitric oxide

chronic liver disease

nitrate and nitrite

Sayı

Makale detayları

Nitric Oxide in Chronic Liver Disease

Yazarlar: Güldal KIRKALI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.511-515

Belge Tipi: Makale

Yayın Tarihi: 5/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000757449

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Nitric oxide

chronic liver disease

nitrate and nitrite

Sayı

Yazarlar:

Güldal KIRKALI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 6, pp.511-515

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757449

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144