Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Semra UTKU; Fatma GÜMÜŞ; Sibel GÜR; Aykut ÖZKUL

Makale detayları

Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Yazarlar:

Semra UTKU | Fatma GÜMÜŞ | Sibel GÜR | Aykut ÖZKUL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 4, pp.503-514

Belge Tipi:

Makale

Yayın Tarihi:

3/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728694

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Four platinum(II) and 4 platinum(IV) complexes with the  structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2]  (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole  ligands as non-leaving groups''), respectively, were synthesized and  characterized by their elemental analyses, and IR and 1H-NMR spectra.   In vitro cytotoxic activities of the platinum(II) and platinum(IV)  complexes were tested against the human MCF-7 (breast cancer) and HeLa  (cervix cancer) cell lines using the cell culture method.  In general,  the platinum(II) complexes were more active than the corresponding  platinum(IV) complexes.  The complexes, which were found to be less  active than cisplatin, exhibited cyctotoxicity comparable to  carboplatin on the human MCF-7 and HeLa cell lines.

 

Four platinum(II) and 4 platinum(IV) complexes with the  structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2]  (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole  ligands as non-leaving groups''), respectively, were synthesized and  characterized by their elemental analyses, and IR and 1H-NMR spectra.   In vitro cytotoxic activities of the platinum(II) and platinum(IV)  complexes were tested against the human MCF-7 (breast cancer) and HeLa  (cervix cancer) cell lines using the cell culture method.  In general,  the platinum(II) complexes were more active than the corresponding  platinum(IV) complexes.  The complexes, which were found to be less  active than cisplatin, exhibited cyctotoxicity comparable to  carboplatin on the human MCF-7 and HeLa cell lines.

Makale detayları

Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Yazarlar: Semra UTKU | Fatma GÜMÜŞ | Sibel GÜR | Aykut ÖZKUL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2007 Vol.31 Issue 4, pp.503-514

Belge Tipi: Makale

Yayın Tarihi: 3/2007

Belge Dili: Türkçe

Document ID (Org No.): 2000728694

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Semra UTKU | Fatma GÜMÜŞ | Sibel GÜR | Aykut ÖZKUL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 4, pp.503-514

Belge Tipi:

Makale

Yayın Tarihi:

3/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728694

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527