Evaluation of the Cases With Pre-Diagnosis of Crimean-Congo Hemorrhagic Fever in Two District Hospitals in Tokat Province

Emine Türkoğlu; Duygu Çerçioğlu

Makale detayları

Evaluation of the Cases With Pre-Diagnosis of Crimean-Congo Hemorrhagic Fever in Two District Hospitals in Tokat Province

Yazarlar:

Emine Türkoğlu | Duygu Çerçioğlu

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 2, pp.10-15

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293219

pISSN:

1303-6610

Anahtar kelimeler:

Özet:

 Objective: Tokat is one of the cities in Turkey where CrimeanCongo hemorrhagic fever CCHF is endemic. Given that CCHF is fatal and contagious, patients should be isolated and hospitalized. This study aimed to compare the epidemiological, clinical, and laboratory findings of CCHF-positive and CCHF-negative cases in two district hospitals in Tokat. Materials and Methods: Patients applied to Turhal and Zile State Hospitals between January 2018 and December 2019 and had a pre-diagnosis of CCHF were included in this casecontrol study. The patients demographic data, symptoms, treatment, and prognosis were recorded. Pre-diagnosis for CCHF was defined as the presence of leukopenia or thrombocytopenia, in addition to the presence of at least two symptoms. Cases had antibodies to CCHF virus or CCHF virus-RNA were defined as CCHF-positive group and the others were CCHF-negative group. Pearsons chi-square test and Fishers test were used to compare the categorical variables. P values that are less than 0.05 were considered statistically significant. Results: Symptoms of headache 20 vs. 18, nausea and vomiting 20 vs. 16, myalgia 18 vs. 16, and diarrhea 11 vs. 5 were more common in the CCHF-positive group than CCHF-negative group. Leukopenia, thrombocytopenia, elevated aspartate aminotransferase AST, alanine aminotransferase ALT, and lactate dehydrogenase LDH levels, and prolongated prothrombin time PT and activated partial thromboplastin time aPTT levels were also more common. AST elevation and PT prolongation were statistically significant p0.01 and p0.003, respectively. The mortality rate in the CCHF-positive group was 3.8. Conclusion: Even if there is no history of tick bite in patients living in the endemic region and presenting with headache and gastrointestinal symptoms, CCHF probability is high in the presence of leukopenia, thrombocytopenia, elevated liver enzymes and LDH levels, prolonged PT and aPTT. CCHF should always be considered in patients with these symptoms and laboratory findings.

 Objective: Tokat is one of the cities in Turkey where CrimeanCongo hemorrhagic fever CCHF is endemic. Given that CCHF is fatal and contagious, patients should be isolated and hospitalized. This study aimed to compare the epidemiological, clinical, and laboratory findings of CCHF-positive and CCHF-negative cases in two district hospitals in Tokat. Materials and Methods: Patients applied to Turhal and Zile State Hospitals between January 2018 and December 2019 and had a pre-diagnosis of CCHF were included in this casecontrol study. The patients demographic data, symptoms, treatment, and prognosis were recorded. Pre-diagnosis for CCHF was defined as the presence of leukopenia or thrombocytopenia, in addition to the presence of at least two symptoms. Cases had antibodies to CCHF virus or CCHF virus-RNA were defined as CCHF-positive group and the others were CCHF-negative group. Pearsons chi-square test and Fishers test were used to compare the categorical variables. P values that are less than 0.05 were considered statistically significant. Results: Symptoms of headache 20 vs. 18, nausea and vomiting 20 vs. 16, myalgia 18 vs. 16, and diarrhea 11 vs. 5 were more common in the CCHF-positive group than CCHF-negative group. Leukopenia, thrombocytopenia, elevated aspartate aminotransferase AST, alanine aminotransferase ALT, and lactate dehydrogenase LDH levels, and prolongated prothrombin time PT and activated partial thromboplastin time aPTT levels were also more common. AST elevation and PT prolongation were statistically significant p0.01 and p0.003, respectively. The mortality rate in the CCHF-positive group was 3.8. Conclusion: Even if there is no history of tick bite in patients living in the endemic region and presenting with headache and gastrointestinal symptoms, CCHF probability is high in the presence of leukopenia, thrombocytopenia, elevated liver enzymes and LDH levels, prolonged PT and aPTT. CCHF should always be considered in patients with these symptoms and laboratory findings.

 Objective: Tokat is one of the cities in Turkey where CrimeanCongo hemorrhagic fever CCHF is endemic. Given that CCHF is fatal and contagious, patients should be isolated and hospitalized. This study aimed to compare the epidemiological, clinical, and laboratory findings of CCHF-positive and CCHF-negative cases in two district hospitals in Tokat. Materials and Methods: Patients applied to Turhal and Zile State Hospitals between January 2018 and December 2019 and had a pre-diagnosis of CCHF were included in this casecontrol study. The patients demographic data, symptoms, treatment, and prognosis were recorded. Pre-diagnosis for CCHF was defined as the presence of leukopenia or thrombocytopenia, in addition to the presence of at least two symptoms. Cases had antibodies to CCHF virus or CCHF virus-RNA were defined as CCHF-positive group and the others were CCHF-negative group. Pearsons chi-square test and Fishers test were used to compare the categorical variables. P values that are less than 0.05 were considered statistically significant. Results: Symptoms of headache 20 vs. 18, nausea and vomiting 20 vs. 16, myalgia 18 vs. 16, and diarrhea 11 vs. 5 were more common in the CCHF-positive group than CCHF-negative group. Leukopenia, thrombocytopenia, elevated aspartate aminotransferase AST, alanine aminotransferase ALT, and lactate dehydrogenase LDH levels, and prolongated prothrombin time PT and activated partial thromboplastin time aPTT levels were also more common. AST elevation and PT prolongation were statistically significant p0.01 and p0.003, respectively. The mortality rate in the CCHF-positive group was 3.8. Conclusion: Even if there is no history of tick bite in patients living in the endemic region and presenting with headache and gastrointestinal symptoms, CCHF probability is high in the presence of leukopenia, thrombocytopenia, elevated liver enzymes and LDH levels, prolonged PT and aPTT. CCHF should always be considered in patients with these symptoms and laboratory findings.

 Amaç: Tokat, Türkiyede Kırım-Kongo kanamalı ateşinin KKKA endemik görüldüğü illerden biridir. KKKA ölümcül ve bulaşıcı olduğu için, hastalar hospitalize edilip izole takip edilmelidir. Bu çalışma ile Tokat ili iki ilçe hastanesinde takip edilen konfirme KKKA vakaları ile KKKAnın ekarte edildiği olgular arasındaki epidemiyolojik, klinik ve laboratuvar bulgularının karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu vaka kontrol çalışmasına, Ocak 2018-Aralık 2019 yılları arasında, Turhal ve Zile Devlet Hastanelerinde, KKKA ön tanısı ile takip edilen vakalar dâhil edildi. Hastaların demografik verileri, klinik bulguları, tedavi ve prognoz bulguları kaydedildi. KKKA ön tanısı en az iki semptomla birlikte lökopeni ya da trombositopeni varlığı olarak tanımlandı. KKKA antikor pozitifliği ya da polimeraz zincir reaksiyonu pozitifliği saptanan olgular KKKA-pozitif grup olarak kabul edilirken, diğerleri KKKA-negatif grup olarak belirlendi. Hospitalize edilmeyen ve 18 yaş altı olgular dışlandı. Kategorik değişkenlerin karşılaştırılmasında Pearson ki kare ve Fishers testleri kullanıldı. İstatistiksel anlamlılık için p0.05 kabul edildi. Bulgular: KKKA-pozitif grupta, negatif gruba kıyasla, baş ağrısı 20 vs. 18, bulantı-kusma 20 vs. 16, myalji 18 vs. 16 ve ishal 11 vs. 5 semptomları daha sıktı. Ayrıca, lökopeni, trombositopeni, aspartat aminotransaminaz AST, alanin aminotransaminaz ALT, laktat dehidrogenaz LDH yüksekliği ile protrombin zamanı PTZ ve aktive parsiyel tromboplastin zamanında aPTT uzama daha sıktı. AST yüksekliği ve PTZ uzaması istatistiksel olarak anlamlıydı sırasıyla; p0.01 ve p0.003. KKKA-pozitif grupta mortalite hızı 3.8di. Sonuç: Endemik bölgede yaşayıp baş ağrısı ve gastrointestinal semptomlarla başvuran olgularda, kene ısırığı öyküsü olmasa bile, lökopeni, trombositopeni, karaciğer enzim yüksekliği KCFT ve LDH yüksekliği, PTZ ve aPTT uzaması saptandığında KKKA olasılığı yüksektir. Bu yakınmalar ve laboratuvar bulguları ile başvuran hastalarda KKKA mutlaka akılda tutulmalıdır.

Makale detayları

Evaluation of the Cases With Pre-Diagnosis of Crimean-Congo Hemorrhagic Fever in Two District Hospitals in Tokat Province

Yazarlar:

Emine Türkoğlu | Duygu Çerçioğlu

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 2, pp.10-15

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293219

pISSN:

1303-6610

Crimean-Congo hemorrhagic fever

epidemiology

leukopenia

thrombocytopeniaKırım-Kongo kanamalı ateşi

epidemiyoloji

lökopeni

trombositopeni

Tokat

Sayı

Makale detayları

Yazarlar: Emine Türkoğlu | Duygu Çerçioğlu

Yayıncı: Kahramanmaras Sutcu Imam University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 2, pp.10-15

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293219

pISSN: 1303-6610

Sayı

Yazarlar:

Emine Türkoğlu | Duygu Çerçioğlu

Yayıncı:

Kahramanmaras Sutcu Imam University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 2, pp.10-15

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293219

pISSN:

1303-6610