Synthesis and antimicrobial activities of some bridged bis-benzimidazole derivatives

Hasan KÜÇÜKBAY; Ülkü YILMAZ; Nihat ŞİRECİ

Makale detayları

Synthesis and antimicrobial activities of some bridged bis-benzimidazole derivatives

Yazarlar:

Hasan KÜÇÜKBAY | Ülkü YILMAZ | Nihat ŞİRECİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 4, pp.561-571

Belge Tipi:

Makale

Yayın Tarihi:

3/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000727790

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Some bis-benzimidazoles derivatives bearing allyl, crotyl,  cinammyl, furfuryl, and thenyl groups were synthesized and their in  vitro antimicrobial activity determined against gram-positive and  gram-negative bacteria, and fungi by disk-diffusion method.  The  structures of all new compounds were identified by 1H-NMR,  13C-NMR, and FT-IR spectroscopic techniques and elemental analysis.  All the compounds synthesized in this work were examined for their in  vitro antimicrobial activities against gram-positive (Staphylococcus  aureus and Bacillus megaterium) and gram-negative bacteria (Klebsiella  pneumoniae and Escherichia coli), and the yeasts like fungi (Candida  globrata and Candida tropicalis).  Compared to the reference  substances, Cefozine and nystatin, most of the compounds showed high  antibacterial and antifungal activities against studied strains with  inhibition zones between 8 and 28 mm.

 

Some bis-benzimidazoles derivatives bearing allyl, crotyl,  cinammyl, furfuryl, and thenyl groups were synthesized and their in  vitro antimicrobial activity determined against gram-positive and  gram-negative bacteria, and fungi by disk-diffusion method.  The  structures of all new compounds were identified by 1H-NMR,  13C-NMR, and FT-IR spectroscopic techniques and elemental analysis.  All the compounds synthesized in this work were examined for their in  vitro antimicrobial activities against gram-positive (Staphylococcus  aureus and Bacillus megaterium) and gram-negative bacteria (Klebsiella  pneumoniae and Escherichia coli), and the yeasts like fungi (Candida  globrata and Candida tropicalis).  Compared to the reference  substances, Cefozine and nystatin, most of the compounds showed high  antibacterial and antifungal activities against studied strains with  inhibition zones between 8 and 28 mm.

Makale detayları

Synthesis and antimicrobial activities of some bridged bis-benzimidazole derivatives

Yazarlar: Hasan KÜÇÜKBAY | Ülkü YILMAZ | Nihat ŞİRECİ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2011 Vol.35 Issue 4, pp.561-571

Belge Tipi: Makale

Yayın Tarihi: 3/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000727790

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Hasan KÜÇÜKBAY | Ülkü YILMAZ | Nihat ŞİRECİ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2011 Vol.35 Issue 4, pp.561-571

Belge Tipi:

Makale

Yayın Tarihi:

3/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000727790

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527