Synthesis, Structural Characterization, and Thermal Stability Investigation of Methoxybenzamide Derivatives Containing the 5-Mercapto-1,3,4-Thiadiazol-2-yl Group

Şenol Yavuz; Ersin Demir; Naki Çolak; Dursun Ali Köse

Makale detayları

Synthesis, Structural Characterization, and Thermal Stability Investigation of Methoxybenzamide Derivatives Containing the 5-Mercapto-1,3,4-Thiadiazol-2-yl Group

Yazarlar:

Şenol Yavuz | Ersin Demir | Naki Çolak | Dursun Ali Köse

Yayıncı:

Hitit University

Ana Başlıklar:

Organic Chemical Synthesis

Dergi:

Hitit Journal Of Science Vol.2 Issue 1, pp.18-25

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340497

pISSN:

3061-9629

Anahtar kelimeler:

Özet:

 Compounds with a methoxy benzamide structure contain a methoxy group OCH₃ and an amide functional group CONH₂ within a benzene ring. This causes the compound to exhibit a complex structure with polar and nonpolar characteristics. These compounds are significant in pharmaceutical chemistry, biological research, and chemical synthesis. Due to its active properties, the NCS linkage in the thiazole ring can chelate metal ions. The antimicrobial activity of benzamide compounds derived from thiazoles and their wide applications in medicine increases the importance of methoxybenzamide derivetives. In this study, 5-amino-1,3,4-thiadiazole-2-thiol compounds were reacted with 2-methoxy, 3-methoxy, and 4-methoxybenzoyl chloride in toluene under a reflux condenser, resulting in the synthesis of methoxybenzamide derivatives a, b, c. The structural characterization of the obtained methoxybenzamide a, b, c compounds were performed using FTIR, LCMS-ESI, 1H NMR, 13C APT spectroscopy, and elemental analysis. Additionally, the thermal stability of the synthesized methoxybenzamide compounds was investigated through thermal analysis TGADTADrTG.

 Compounds with a methoxy benzamide structure contain a methoxy group OCH₃ and an amide functional group CONH₂ within a benzene ring. This causes the compound to exhibit a complex structure with polar and nonpolar characteristics. These compounds are significant in pharmaceutical chemistry, biological research, and chemical synthesis. Due to its active properties, the NCS linkage in the thiazole ring can chelate metal ions. The antimicrobial activity of benzamide compounds derived from thiazoles and their wide applications in medicine increases the importance of methoxybenzamide derivetives. In this study, 5-amino-1,3,4-thiadiazole-2-thiol compounds were reacted with 2-methoxy, 3-methoxy, and 4-methoxybenzoyl chloride in toluene under a reflux condenser, resulting in the synthesis of methoxybenzamide derivatives a, b, c. The structural characterization of the obtained methoxybenzamide a, b, c compounds were performed using FTIR, LCMS-ESI, 1H NMR, 13C APT spectroscopy, and elemental analysis. Additionally, the thermal stability of the synthesized methoxybenzamide compounds was investigated through thermal analysis TGADTADrTG.

 Compounds with a methoxy benzamide structure contain a methoxy group OCH₃ and an amide functional group CONH₂ within a benzene ring. This causes the compound to exhibit a complex structure with polar and nonpolar characteristics. These compounds are significant in pharmaceutical chemistry, biological research, and chemical synthesis. Due to its active properties, the NCS linkage in the thiazole ring can chelate metal ions. The antimicrobial activity of benzamide compounds derived from thiazoles and their wide applications in medicine increases the importance of methoxybenzamide derivetives. In this study, 5-amino-1,3,4-thiadiazole-2-thiol compounds were reacted with 2-methoxy, 3-methoxy, and 4-methoxybenzoyl chloride in toluene under a reflux condenser, resulting in the synthesis of methoxybenzamide derivatives a, b, c. The structural characterization of the obtained methoxybenzamide a, b, c compounds were performed using FTIR, LCMS-ESI, 1H NMR, 13C APT spectroscopy, and elemental analysis. Additionally, the thermal stability of the synthesized methoxybenzamide compounds was investigated through thermal analysis TGADTADrTG.

 Compounds with a methoxy benzamide structure contain a methoxy group OCH₃ and an amide functional group CONH₂ within a benzene ring. This causes the compound to exhibit a complex structure with polar and nonpolar characteristics. These compounds are significant in pharmaceutical chemistry, biological research, and chemical synthesis. Due to its active properties, the NCS linkage in the thiazole ring can chelate metal ions. The antimicrobial activity of benzamide compounds derived from thiazoles and their wide applications in medicine increases the importance of methoxybenzamide derivetives. In this study, 5-amino-1,3,4-thiadiazole-2-thiol compounds were reacted with 2-methoxy, 3-methoxy, and 4-methoxybenzoyl chloride in toluene under a reflux condenser, resulting in the synthesis of methoxybenzamide derivatives a, b, c. The structural characterization of the obtained methoxybenzamide a, b, c compounds were performed using FTIR, LCMS-ESI, 1H NMR, 13C APT spectroscopy, and elemental analysis. Additionally, the thermal stability of the synthesized methoxybenzamide compounds was investigated through thermal analysis TGADTADrTG.

Makale detayları

Yazarlar: Şenol Yavuz | Ersin Demir | Naki Çolak | Dursun Ali Köse

Yayıncı: Hitit University

Ana Başlıklar: Organic Chemical Synthesis

Dergi: Hitit Journal Of Science Vol.2 Issue 1, pp.18-25

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001340497

pISSN: 3061-9629

Sayı

Yazarlar:

Şenol Yavuz | Ersin Demir | Naki Çolak | Dursun Ali Köse

Yayıncı:

Hitit University

Ana Başlıklar:

Organic Chemical Synthesis

Dergi:

Hitit Journal Of Science Vol.2 Issue 1, pp.18-25

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001340497

pISSN:

3061-9629