Increased Lipid Peroxidation and Decreased Antioxidant Response in Serum and Cerebrospinal Fluid in Acute Ischemic Stroke

Abdulkadir YILDIRIM

Makale detayları

Increased Lipid Peroxidation and Decreased Antioxidant Response in Serum and Cerebrospinal Fluid in Acute Ischemic Stroke

Yazarlar:

Abdulkadir YILDIRIM

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2007 Vol.37 Issue 2, pp.75-81

Belge Tipi:

Makale

Yayın Tarihi:

1/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000756037

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background and Aim: The pathogenesis of brain damage in ischemic stroke is highly complex. The aim of the present study was to investigate the presence of oxidative stress in ischemic stroke and to determine whether the measured oxidative stress markers in serum and cerebrospinal fluid (CSF) were associated with infarction volume, and the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS).   Materials and Methods: The study included 32 patients with acute ischemic stroke within 48 h of onset and 18 suitable controls. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity, glutathione (GSH) and malondialdehyde (MDA) level, and total antioxidant capacity (TAC) were measured in both serum and CSF samples of the participants.   Results: GPX activity, GSH level, and TAC in the serum and CSF samples of stroke patients were significantly lower than those in the controls. In the patient group, SOD activity in serum was lower and SOD activity in CSF was higher compared to the control group. Both serum and CSF MDA concentrations were significantly higher among stroke patients as compared to the controls.   Conclusions: The lower activity levels of antioxidant molecules measured in this study could have resulted from increased free radical generation, which may confirm the presence of oxidative stress in acute ischemic stroke; however, the levels of oxidative stress markers in serum and CSF may not always be indicative of neurological deficit.

 

Background and Aim: The pathogenesis of brain damage in ischemic stroke is highly complex. The aim of the present study was to investigate the presence of oxidative stress in ischemic stroke and to determine whether the measured oxidative stress markers in serum and cerebrospinal fluid (CSF) were associated with infarction volume, and the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS).   Materials and Methods: The study included 32 patients with acute ischemic stroke within 48 h of onset and 18 suitable controls. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity, glutathione (GSH) and malondialdehyde (MDA) level, and total antioxidant capacity (TAC) were measured in both serum and CSF samples of the participants.   Results: GPX activity, GSH level, and TAC in the serum and CSF samples of stroke patients were significantly lower than those in the controls. In the patient group, SOD activity in serum was lower and SOD activity in CSF was higher compared to the control group. Both serum and CSF MDA concentrations were significantly higher among stroke patients as compared to the controls.   Conclusions: The lower activity levels of antioxidant molecules measured in this study could have resulted from increased free radical generation, which may confirm the presence of oxidative stress in acute ischemic stroke; however, the levels of oxidative stress markers in serum and CSF may not always be indicative of neurological deficit.

Makale detayları

Increased Lipid Peroxidation and Decreased Antioxidant Response in Serum and Cerebrospinal Fluid in Acute Ischemic Stroke

Yazarlar:

Abdulkadir YILDIRIM

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2007 Vol.37 Issue 2, pp.75-81

Belge Tipi:

Makale

Yayın Tarihi:

1/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000756037

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Ischemic stroke

oxidative stress

cerebrospinal fluid

malondialdehyde

total antioxidant capacity

Sayı

Makale detayları

Increased Lipid Peroxidation and Decreased Antioxidant Response in Serum and Cerebrospinal Fluid in Acute Ischemic Stroke

Yazarlar: Abdulkadir YILDIRIM

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2007 Vol.37 Issue 2, pp.75-81

Belge Tipi: Makale

Yayın Tarihi: 1/2007

Belge Dili: Türkçe

Document ID (Org No.): 2000756037

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Ischemic stroke

oxidative stress

cerebrospinal fluid

malondialdehyde

total antioxidant capacity

Sayı

Yazarlar:

Abdulkadir YILDIRIM

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2007 Vol.37 Issue 2, pp.75-81

Belge Tipi:

Makale

Yayın Tarihi:

1/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000756037

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144