Investigation of Antibacterial Effects of Laurus nobilis Extracts on Some Pathogenic Bacteria and the Interactions of Components with MreC Protein by Molecular Docking Method

Serkan Sugeçti; Mustafa Sertçelik

Makale detayları

Investigation of Antibacterial Effects of Laurus nobilis Extracts on Some Pathogenic Bacteria and the Interactions of Components with MreC Protein by Molecular Docking Method

Yazarlar:

Serkan Sugeçti | Mustafa Sertçelik

Yayıncı:

Kafkas University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Caucasian Journal of Science Vol.11 Issue 2, pp.95-104

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001337875

pISSN:

2148-6840

Anahtar kelimeler:

Özet:

 The development of multiple antibiotic resistance by pathogenic microorganisms causes prolongation of treatment periods, increased mortality rates, and economic losses. In this study, the need to develop alternative antibacterial agents due to the development of resistance to conventional antibiotics was addressed. The antibacterial effects of extracts obtained from Laurus nobilis leaves against Escherichia coli and Proteus mirabilis pathogens were investigated. In the study, it was determined that L. nobilis leaf extracts, especially at high doses 50 µL, provided inhibition on both pathogens. In addition, the interaction potential of the volatile oil components of bay leaf with proteins that control bacterial cell wall formation was investigated by molecular docking method. The results show that L. nobilis extracts may be an effective alternative, especially against pathogens that develop multiple antibiotic resistance.

 The development of multiple antibiotic resistance by pathogenic microorganisms causes prolongation of treatment periods, increased mortality rates, and economic losses. In this study, the need to develop alternative antibacterial agents due to the development of resistance to conventional antibiotics was addressed. The antibacterial effects of extracts obtained from Laurus nobilis leaves against Escherichia coli and Proteus mirabilis pathogens were investigated. In the study, it was determined that L. nobilis leaf extracts, especially at high doses 50 µL, provided inhibition on both pathogens. In addition, the interaction potential of the volatile oil components of bay leaf with proteins that control bacterial cell wall formation was investigated by molecular docking method. The results show that L. nobilis extracts may be an effective alternative, especially against pathogens that develop multiple antibiotic resistance.

 The development of multiple antibiotic resistance by pathogenic microorganisms causes prolongation of treatment periods, increased mortality rates, and economic losses. In this study, the need to develop alternative antibacterial agents due to the development of resistance to conventional antibiotics was addressed. The antibacterial effects of extracts obtained from Laurus nobilis leaves against Escherichia coli and Proteus mirabilis pathogens were investigated. In the study, it was determined that L. nobilis leaf extracts, especially at high doses 50 µL, provided inhibition on both pathogens. In addition, the interaction potential of the volatile oil components of bay leaf with proteins that control bacterial cell wall formation was investigated by molecular docking method. The results show that L. nobilis extracts may be an effective alternative, especially against pathogens that develop multiple antibiotic resistance.

 Patojen mikroorganizmaların çoklu antibiyotik direnci geliştirmesi tedavi sürelerinin uzaması, ölüm oranlarının artması ve ekonomik kayıplara neden olmaktadır. Bu çalışmada, geleneksel antibiyotiklere karşı gelişen direnç nedeniyle alternatif antibakteriyel ajanlar geliştirilmesi ihtiyacı ele alınmıştır. Laurus nobilis yapraklarından elde edilen ekstraktların Escherichia coli ve Proteus mirabilis patojenlerine karşı antibakteriyel etkileri araştırılmıştır. Araştırmada, L. nobilis yaprak ekstraktlarının, özellikle yüksek dozlarda 50 µL, her iki patojen üzerinde de inhibisyon sağladığı belirlenmiştir. Ayrıca, moleküler kenetlenme yöntemi ile defne yaprağının uçucu yağ bileşenlerinin bakteri hücre duvarı oluşumunu kontrol eden proteinlerle etkileşim potansiyeli incelenmiştir. Sonuçlar, L. nobilis ekstraktlarının, özellikle çoklu antibiyotik direnci geliştiren patojenlere karşı, etkili bir alternatif olabileceğini göstermektedir.

Makale detayları

Investigation of Antibacterial Effects of Laurus nobilis Extracts on Some Pathogenic Bacteria and the Interactions of Components with MreC Protein by Molecular Docking Method

Yazarlar:

Serkan Sugeçti | Mustafa Sertçelik

Yayıncı:

Kafkas University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Caucasian Journal of Science Vol.11 Issue 2, pp.95-104

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001337875

pISSN:

2148-6840

Pathogen

Antibacterial

MreC

Escherichia coli

Laurus nobilisPatojen

Antibakteriyel

MreC

Escherichia coli

Laurus nobilis

Sayı

Makale detayları

Yazarlar: Serkan Sugeçti | Mustafa Sertçelik

Yayıncı: Kafkas University

Ana Başlıklar: Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi: Caucasian Journal of Science Vol.11 Issue 2, pp.95-104

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001337875

pISSN: 2148-6840

Sayı

Yazarlar:

Serkan Sugeçti | Mustafa Sertçelik

Yayıncı:

Kafkas University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Caucasian Journal of Science Vol.11 Issue 2, pp.95-104

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001337875

pISSN:

2148-6840