Exploring the Complementary Influence of an Oleuropein-Enriched Phytochemical Extract on Neuro-biochemistry, Behavior, and Histopathology in Aging and Depressed Male Rats

Shirin Tarbiat; Kübra Ergün; Refika Aydoğdu; Estelle Larissa Ndengom Djomaleu; Kürşat Filikci

Makale detayları

Exploring the Complementary Influence of an Oleuropein-Enriched Phytochemical Extract on Neuro-biochemistry, Behavior, and Histopathology in Aging and Depressed Male Rats

Yazarlar:

Shirin Tarbiat | Kübra Ergün | Refika Aydoğdu | Estelle Larissa Ndengom Djomaleu | Kürşat Filikci

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Eczacılık Biyokimyası

Dergi:

Black Sea Journal of Health Science Vol.8 Issue 2, pp.58-69

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341730

pISSN:

2619-9041

Anahtar kelimeler:

Özet:

 Aging correlates with neurodegenerative diseases such as depression, marked by neuro-biochemical changes triggering neuronal loss. Nutraceuticals exhibit antioxidant and neuroprotective properties and offer potential intervention. Our study examines the preventive effects of an olive leaf extract consisting of 20 pure oleuropein in an animal model of aging and depression. Aging in Wistar rats was induced by intraperitoneal injections of 150 mg of D-galactosekg body weight for 6 weeks. The depression was caused by forced swimming. We examined Monoamine oxidase and acetylcholinesterase activities, histopathology of the brain, and the serum plasminogen activator inhibitor-1, superoxide dismutase, and monoaldehyde levels of all animal groups. Depressed and aged rats showed increased Monoamine oxidase, acetylcholinesterase, and plasminogen activator inhibitor-1 levels, and a decrease in superoxide dismutase levels. The administration of 200 mg of extract before depression or aging inductions significantly reduced the Monoamine oxidase and acetylcholinesterase activities. Degenerationnecrosis was observed in neurons of all experimental animal groups. We demonstrate that the olive leaf extract with 20 pure oleuropein markedly maintained the neurotransmitter levels in the brain and enhanced the antioxidant defense system in depressed and aged animal models but was unable to yield behavioral benefits.

 Aging correlates with neurodegenerative diseases such as depression, marked by neuro-biochemical changes triggering neuronal loss. Nutraceuticals exhibit antioxidant and neuroprotective properties and offer potential intervention. Our study examines the preventive effects of an olive leaf extract consisting of 20 pure oleuropein in an animal model of aging and depression. Aging in Wistar rats was induced by intraperitoneal injections of 150 mg of D-galactosekg body weight for 6 weeks. The depression was caused by forced swimming. We examined Monoamine oxidase and acetylcholinesterase activities, histopathology of the brain, and the serum plasminogen activator inhibitor-1, superoxide dismutase, and monoaldehyde levels of all animal groups. Depressed and aged rats showed increased Monoamine oxidase, acetylcholinesterase, and plasminogen activator inhibitor-1 levels, and a decrease in superoxide dismutase levels. The administration of 200 mg of extract before depression or aging inductions significantly reduced the Monoamine oxidase and acetylcholinesterase activities. Degenerationnecrosis was observed in neurons of all experimental animal groups. We demonstrate that the olive leaf extract with 20 pure oleuropein markedly maintained the neurotransmitter levels in the brain and enhanced the antioxidant defense system in depressed and aged animal models but was unable to yield behavioral benefits.

 Aging correlates with neurodegenerative diseases such as depression, marked by neuro-biochemical changes triggering neuronal loss. Nutraceuticals exhibit antioxidant and neuroprotective properties and offer potential intervention. Our study examines the preventive effects of an olive leaf extract consisting of 20 pure oleuropein in an animal model of aging and depression. Aging in Wistar rats was induced by intraperitoneal injections of 150 mg of D-galactosekg body weight for 6 weeks. The depression was caused by forced swimming. We examined Monoamine oxidase and acetylcholinesterase activities, histopathology of the brain, and the serum plasminogen activator inhibitor-1, superoxide dismutase, and monoaldehyde levels of all animal groups. Depressed and aged rats showed increased Monoamine oxidase, acetylcholinesterase, and plasminogen activator inhibitor-1 levels, and a decrease in superoxide dismutase levels. The administration of 200 mg of extract before depression or aging inductions significantly reduced the Monoamine oxidase and acetylcholinesterase activities. Degenerationnecrosis was observed in neurons of all experimental animal groups. We demonstrate that the olive leaf extract with 20 pure oleuropein markedly maintained the neurotransmitter levels in the brain and enhanced the antioxidant defense system in depressed and aged animal models but was unable to yield behavioral benefits.

 Aging correlates with neurodegenerative diseases such as depression, marked by neuro-biochemical changes triggering neuronal loss. Nutraceuticals exhibit antioxidant and neuroprotective properties and offer potential intervention. Our study examines the preventive effects of an olive leaf extract consisting of 20 pure oleuropein in an animal model of aging and depression. Aging in Wistar rats was induced by intraperitoneal injections of 150 mg of D-galactosekg body weight for 6 weeks. The depression was caused by forced swimming. We examined Monoamine oxidase and acetylcholinesterase activities, histopathology of the brain, and the serum plasminogen activator inhibitor-1, superoxide dismutase, and monoaldehyde levels of all animal groups. Depressed and aged rats showed increased Monoamine oxidase, acetylcholinesterase, and plasminogen activator inhibitor-1 levels, and a decrease in superoxide dismutase levels. The administration of 200 mg of extract before depression or aging inductions significantly reduced the Monoamine oxidase and acetylcholinesterase activities. Degenerationnecrosis was observed in neurons of all experimental animal groups. We demonstrate that the olive leaf extract with 20 pure oleuropein markedly maintained the neurotransmitter levels in the brain and enhanced the antioxidant defense system in depressed and aged animal models but was unable to yield behavioral benefits.

Makale detayları

Exploring the Complementary Influence of an Oleuropein-Enriched Phytochemical Extract on Neuro-biochemistry, Behavior, and Histopathology in Aging and Depressed Male Rats

Yazarlar:

Shirin Tarbiat | Kübra Ergün | Refika Aydoğdu | Estelle Larissa Ndengom Djomaleu | Kürşat Filikci

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Eczacılık Biyokimyası

Dergi:

Black Sea Journal of Health Science Vol.8 Issue 2, pp.58-69

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341730

pISSN:

2619-9041

Oleuropein

Depression

Aging

Monoaminoxidase

AcetylcholinesteraseOleuropein

Depression

Aging

Monoaminoxidase

Acetylcholinesterase

Sayı

Makale detayları

Yazarlar: Shirin Tarbiat | Kübra Ergün | Refika Aydoğdu | Estelle Larissa Ndengom Djomaleu | Kürşat Filikci

Yayıncı: Karyay Karadeniz Yayımcılık

Ana Başlıklar: Eczacılık Biyokimyası

Dergi: Black Sea Journal of Health Science Vol.8 Issue 2, pp.58-69

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001341730

pISSN: 2619-9041

Sayı

Yazarlar:

Shirin Tarbiat | Kübra Ergün | Refika Aydoğdu | Estelle Larissa Ndengom Djomaleu | Kürşat Filikci

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Eczacılık Biyokimyası

Dergi:

Black Sea Journal of Health Science Vol.8 Issue 2, pp.58-69

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001341730

pISSN:

2619-9041