Synthesis of 2-[2-(3,4,5-Trimethoxybenzoyloxy)ethyl]pyrrolidine Hydrochloride Controlled by GC-MS, 1H and 13C NMR Analyses

Alicja WODNICKA; Maygorzata DZIECIOL

Makale detayları

Synthesis of 2-[2-(3,4,5-Trimethoxybenzoyloxy)ethyl]pyrrolidine Hydrochloride Controlled by GC-MS, 1H and 13C NMR Analyses

Yazarlar:

Alicja WODNICKA | Maygorzata DZIECIOL

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 6, pp.641-646

Belge Tipi:

Makale

Yayın Tarihi:

5/2005

Belge Dili:

İngilizce

Document ID (Org No.):

2000729002

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The synthesis of  2-[2-(3,4,5-trimethoxybenzoyloxy)ethyl]pyrrolidine hydrochloride was  performed using 2-(2-hydroxyethyl)pyrrolidine as a starting material.   Before the O-acylation reaction with 3,4,5-trimethoxybenzoyl chloride,  the amino group was protected using benzyl chlorocarbonate.  The  removal of the blocking group was carried out in modified conditions,  avoiding the alcoholysis of the ester bond.  The final product was  separated from its structural isomer by precipitation as its  hydrochloride salt.  Some steps of the synthesis were controlled by  GC-MS. The identification of the respective compounds was performed by  mass spectra analyses and confirmed by 1H NMR, 13C NMR, IR and  elemental analyses.

 

The synthesis of  2-[2-(3,4,5-trimethoxybenzoyloxy)ethyl]pyrrolidine hydrochloride was  performed using 2-(2-hydroxyethyl)pyrrolidine as a starting material.   Before the O-acylation reaction with 3,4,5-trimethoxybenzoyl chloride,  the amino group was protected using benzyl chlorocarbonate.  The  removal of the blocking group was carried out in modified conditions,  avoiding the alcoholysis of the ester bond.  The final product was  separated from its structural isomer by precipitation as its  hydrochloride salt.  Some steps of the synthesis were controlled by  GC-MS. The identification of the respective compounds was performed by  mass spectra analyses and confirmed by 1H NMR, 13C NMR, IR and  elemental analyses.

Makale detayları

Synthesis of 2-[2-(3,4,5-Trimethoxybenzoyloxy)ethyl]pyrrolidine Hydrochloride Controlled by GC-MS, 1H and 13C NMR Analyses

Yazarlar: Alicja WODNICKA | Maygorzata DZIECIOL

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2005 Vol.29 Issue 6, pp.641-646

Belge Tipi: Makale

Yayın Tarihi: 5/2005

Belge Dili: İngilizce

Document ID (Org No.): 2000729002

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Alicja WODNICKA | Maygorzata DZIECIOL

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 6, pp.641-646

Belge Tipi:

Makale

Yayın Tarihi:

5/2005

Belge Dili:

İngilizce

Document ID (Org No.):

2000729002

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527