The Effect of  N-butyl-2-Cyanoacrylate on Wound Healing in Head Neck Region

Zeliha KAPUSUZ GENCER; Mahmut ÖZKIRIŞ; Levent SAYDAM; Yusuf Kenan DAĞLIOĞLU; Muzaffer GENCER; Sait POLAT

doi:https://doi.org/10.32448/entupdates.425951

Makale detayları

The Effect of N-butyl-2-Cyanoacrylate on Wound Healing in Head Neck Region

Yazarlar:

Zeliha KAPUSUZ GENCER | Mahmut ÖZKIRIŞ | Levent SAYDAM | Yusuf Kenan DAĞLIOĞLU | Muzaffer GENCER | Sait POLAT

Yayıncı:

Sürekli Eğitim ve Bilimsel Araştırmalar Derneği

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

ENT Updates 2019 Vol.9 Issue 1, pp.18-24

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000781687

Sıklık:

Üç Yıllık

eISSN:

2149-6498

pISSN:

2149-7109

DOI:

https://doi.org/10.32448/entupdates.425951

Özet:

 




OBJECTIVE



To
compare the histological regeneration characteristics of open wound
on head neck by a topical
antiseptic
solution (Batticon®
solution 5%; Adeka, Samsun, Turkey)
or
a tissue adhesive (N-butyl-2-cyanoacrylate, Glubran 2, GEM Company,
Italy) in experimentally created rabbit auricular open wound. 




MATERIAL AND
METHOD 




Twenty-eight
female rabbits (New Zealand genus), weighing 3 to 4 kg, were handled
daily for 2 weeks prior to surgical manipulation to condition them to
behavior testing. The control group consisted of seven rabbits. The
21 rabbits were randomly divided into three
groups based on the harvesting day. In control group a segment of ear
auricula was resected and sent to histological examination for
comparison with the study group findings.  In the study group both
auricular skin of each animal was exposed and 1x1 cm epidermal
resection area was created open wound in rabbit ears that is to be a
model for open tissue injury and applied
as a
topical
antiseptic
solution
(Batticon
® solution 5%; Adeka, Samsun, Turkey)
on one side and by application of tissue adhesive (Glubran 2, GEM
Company, Italy) on the other side.  Following this application at
2nd,
4th
and 6th days the animals were harvested and histological regeneration
characteristics of open wound examined by electron microscopy and
compared to the control group’s histological findings.





RESULTS 




Electron
microscopic examination of open wound at consecutive 2nd,
4th
and 6th
days revealed increased regeneration findings in tissue adhesive
group when compared to a antiseptic
solution
group.



CONCLUSION



Based
on the findings of this animal study we conclude that
N-butyl-2-cyanoacrylate
is an appropriate material for open wound on head and neck region.



.

Makale detayları

The Effect of N-butyl-2-Cyanoacrylate on Wound Healing in Head Neck Region

Yazarlar: Zeliha KAPUSUZ GENCER | Mahmut ÖZKIRIŞ | Levent SAYDAM | Yusuf Kenan DAĞLIOĞLU | Muzaffer GENCER | Sait POLAT

Yayıncı: Sürekli Eğitim ve Bilimsel Araştırmalar Derneği

Ana Başlıklar: Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi: ENT Updates 2019 Vol.9 Issue 1, pp.18-24

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000781687

Sıklık: Üç Yıllık

eISSN: 2149-6498

pISSN: 2149-7109

DOI: https://doi.org/10.32448/entupdates.425951

Sayı

Yazarlar:

Zeliha KAPUSUZ GENCER | Mahmut ÖZKIRIŞ | Levent SAYDAM | Yusuf Kenan DAĞLIOĞLU | Muzaffer GENCER | Sait POLAT

Yayıncı:

Sürekli Eğitim ve Bilimsel Araştırmalar Derneği

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

ENT Updates 2019 Vol.9 Issue 1, pp.18-24

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000781687

Sıklık:

Üç Yıllık

eISSN:

2149-6498

pISSN:

2149-7109

DOI:

https://doi.org/10.32448/entupdates.425951