The Impact of 17Β Estradiol Level Variations on Blood Lymphocyte Counts Among Healthy Females

Gökçen ÖRGÜL; H. Meltem YÜCESOY; Oytun PORTAKAL; Meral BEKSAÇ; M. Sinan BEKSAÇ

Makale detayları

The Impact of 17Β Estradiol Level Variations on Blood Lymphocyte Counts Among Healthy Females

Yazarlar:

Gökçen ÖRGÜL | H. Meltem YÜCESOY | Oytun PORTAKAL | Meral BEKSAÇ | M. Sinan BEKSAÇ

Yayıncı:

Marmara University

Dergi:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 2, pp.118-121

Belge Tipi:

Makale

Yayın Tarihi:

6/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000907173

Sıklık:

Aylık

eISSN:

2459-1459

Anahtar kelimeler:

Özet:

 


Objective: To investigate the effects of 17β-estradiol (E2) levels on

blood lymphocyte counts in women.

Methods: Blood samples were obtained from 428 healthy women. Serum

E2 levels were measured using the solid-phase enzyme-labelled

chemiluminescent method. Complete blood count was performed by

a fully automated cell counter. White blood cell differential, including

lymphocytes, was performed by volume, conductivity, and five-part

scatter measurements (VCS technology). The participants were divided

into four groups, according to the blood lymphocyte levels: <1000

cells/μL (Group A), 1001–2000 cells/μL (Group B), 2001–3000 cells/μL

(Group C), and 3001–4000 cells/μL (Group D).

Results: The mean age of the participants was 37.03 years (between

15 and 66 years). E2 levels on admission in the study group ranged

from <11 to 4264 pg/mL, and the median E2 level was 121.98. Twelve

women had high levels of E2, as a result of the ovulation induction

treatment. Total lymphocyte count varied between 0.9×103 to as high

as 105×103 cells/μL, and the median lymphocyte count was 2.6×103

cells/μL. Lymphocyte–white blood cell ratio (LWR) was also studied

in addition to lymphocyte levels. The lowest LWR value was 9.1 and

the highest was 99.7. The medium E2 concentration was 40.3±11,

114±144, 117.2±128, and 192.2±595 in Groups A–D, respectively. The

relationship between lymphocyte counts and LWR was positive, as expected.

There were no statistically significant differences in lymphocyte

counts either with age or E2 levels.

Conclusion: It is well established that estrogens affect lymphocyte

functions in several ways. In the present study, we were unable to

demonstrate a correlation between the E2 serum levels and blood

lymphocyte counts in women.

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Makale detayları

The Impact of 17Β Estradiol Level Variations on Blood Lymphocyte Counts Among Healthy Females

Yazarlar:

Gökçen ÖRGÜL | H. Meltem YÜCESOY | Oytun PORTAKAL | Meral BEKSAÇ | M. Sinan BEKSAÇ

Yayıncı:

Marmara University

Dergi:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 2, pp.118-121

Belge Tipi:

Makale

Yayın Tarihi:

6/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000907173

Sıklık:

Aylık

eISSN:

2459-1459

17 β estradiol

lenfosit

beyaz kan hücreleri

Sayı

Makale detayları

The Impact of 17Β Estradiol Level Variations on Blood Lymphocyte Counts Among Healthy Females

Yazarlar: Gökçen ÖRGÜL | H. Meltem YÜCESOY | Oytun PORTAKAL | Meral BEKSAÇ | M. Sinan BEKSAÇ

Yayıncı: Marmara University

Dergi: Clinical and Experimental Health Sciences 2018 Vol.8 Issue 2, pp.118-121

Belge Tipi: Makale

Yayın Tarihi: 6/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000907173

Sıklık: Aylık

eISSN: 2459-1459

17 β estradiol

lenfosit

beyaz kan hücreleri

Sayı

Yazarlar:

Gökçen ÖRGÜL | H. Meltem YÜCESOY | Oytun PORTAKAL | Meral BEKSAÇ | M. Sinan BEKSAÇ

Yayıncı:

Marmara University

Dergi:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 2, pp.118-121

Belge Tipi:

Makale

Yayın Tarihi:

6/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000907173

Sıklık:

Aylık

eISSN:

2459-1459