Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Sezer ACAR; Gönül ÇATLI; Tuncay KÜME; Hale Ünver TUHAN; Özlem Gürsoy ÇALAN; Korcan DEMİR; Ece BÖBER; Ayhan ABACI

Makale detayları

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Yazarlar:

Sezer ACAR | Gönül ÇATLI | Tuncay KÜME | Hale Ünver TUHAN | Özlem Gürsoy ÇALAN | Korcan DEMİR | Ece BÖBER | Ayhan ABACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.378-385

Belge Tipi:

Makale

Yayın Tarihi:

3/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750841

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis.  e goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition.  Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed.  Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children had signi cantly higher nesfatin-1 (2.76 ± 0.4 vs. 1.56 ± 0.7, P < 0.001) and lower leptin levels (2.21 ± 2.0 vs. 5.21 ± 2.4, P < 0.001) than those of the control subjects. Nesfatin-1 levels were signi cantly associated with only leptin levels, a er adjusting for age and BMI (r = ?0.371, P = 0.001).  Conclusion:  The present study is the  rst to evaluate nesfatin-1 levels in relation with anthropometric and metabolic parameters in children with chronic malnutrition, who were subsequently found to have signi cantly higher nesfatin-1 levels. Our study underlines that nesfatin-1 may play a role in the development of malnutrition by inhibiting food intake in children.

Makale detayları

Increased concentrations of serum nesfatin-1 levels in childhood with idiopathic chronic malnutrition

Yazarlar: Sezer ACAR | Gönül ÇATLI | Tuncay KÜME | Hale Ünver TUHAN | Özlem Gürsoy ÇALAN | Korcan DEMİR | Ece BÖBER | Ayhan ABACI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.378-385

Belge Tipi: Makale

Yayın Tarihi: 3/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750841

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Sezer ACAR | Gönül ÇATLI | Tuncay KÜME | Hale Ünver TUHAN | Özlem Gürsoy ÇALAN | Korcan DEMİR | Ece BÖBER | Ayhan ABACI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 2, pp.378-385

Belge Tipi:

Makale

Yayın Tarihi:

3/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750841

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144