All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect  of vitamin E and sodium selenite

Dilek PANDIR; Sedat PER; Züleyha DOĞANYİĞİT; Fatih Oğuz BEKDEMİR; Gülşife GÖK; Ali DEMİRBAĞ

Makale detayları

All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite

Yazarlar:

Dilek PANDIR | Sedat PER | Züleyha DOĞANYİĞİT | Fatih Oğuz BEKDEMİR | Gülşife GÖK | Ali DEMİRBAĞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Zoology 2019 Vol.43 Issue 6, pp.566-579

Belge Tipi:

Makale

Yayın Tarihi:

10/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000773158

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179

Özet:

 

This work was planned to research the effects of lipopolysaccharide (LPS) and/or vitamin E (VE) and sodium selenite (SS), which have antioxidant properties, administered to the liver tissue of male rats. For this purpose, histopathology, immunohistochemistry, antioxidant capacity, terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling assay, liver function, and DNA structure tests were performed. The lipid profile was also evaluated in this study. Rats that were administered LPS were treated with VE and/or SS. The liver function tests and lipid profile parameters showed statistically significant changes and histological alterations in the LPS treated groups. The number of cells entering apoptosis was increased by LPS administration when compared to the control group. LPS treatment increased the DNA damage and decreased the ferric reducing antioxidant power and trolox equivalent antioxidant capacity values when compared to the control group. VE and/or SS provided protective effects against the examined parameters. These results indicated that we can assume that the treatment of VE and SS together may be more efficient than using them individually against LPS.

Makale detayları

All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite

Yazarlar: Dilek PANDIR | Sedat PER | Züleyha DOĞANYİĞİT | Fatih Oğuz BEKDEMİR | Gülşife GÖK | Ali DEMİRBAĞ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Zoology 2019 Vol.43 Issue 6, pp.566-579

Belge Tipi: Makale

Yayın Tarihi: 10/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000773158

Sıklık: İki Aylık

eISSN: 1303-6114

pISSN: 1300-0179

Sayı

Yazarlar:

Dilek PANDIR | Sedat PER | Züleyha DOĞANYİĞİT | Fatih Oğuz BEKDEMİR | Gülşife GÖK | Ali DEMİRBAĞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Zoology 2019 Vol.43 Issue 6, pp.566-579

Belge Tipi:

Makale

Yayın Tarihi:

10/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000773158

Sıklık:

İki Aylık

eISSN:

1303-6114

pISSN:

1300-0179