Electrochemical behavior and voltammetric determination of some   nitro-substituted benzamide compounds

Özlem SAĞLAM; Ferah Cömert ÖNDER; Tuğba GÜNGÖR; Mehmet AY; Yusuf DİLGİN

Makale detayları

Electrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds

Yazarlar:

Özlem SAĞLAM | Ferah Cömert ÖNDER | Tuğba GÜNGÖR | Mehmet AY | Yusuf DİLGİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 3, pp.780-793

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000726112

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Voltammetric behaviors of six nitro-substituted   benzamides, which are potential prodrug candidates for nitroreductase-based   cancer therapy, were investigated using cyclic voltammetry (CV) and   differential pulse voltammetry (DPV). The electrochemical behavior of   aromatic nitro (ArNO2)2)_{2}) compounds by CV indicates that  compounds   involve various reduction/oxidation steps including the formation of   aromatic nitro radical, nitroso, hydroxylamine, and amine groups.   Applicability of the voltammetric determination of these prodrug candidates was   studied by recording their DPVs, carried out in mixed media (Britton   Robinson buffer solution +++ DMF) at various pH values on a pencil graphite   electrode (PGE). Results show that the PGE can offer a disposable, low-cost,   and sensitive electrochemical determination method for identifying nitro   benzamide compounds. Under the experimental conditions, the PGE had a linear   response range from 0.5 to 100 μμ\mu M 4-nitro-NNN-(2-nitrophenyl)benzamide   (compound 2). This voltammetric procedure indicates that   nitro-substituted benzamide drugs can be successfully determined in   pharmaceutical samples.

Makale detayları

Electrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds

Yazarlar: Özlem SAĞLAM | Ferah Cömert ÖNDER | Tuğba GÜNGÖR | Mehmet AY | Yusuf DİLGİN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2018 Vol.42 Issue 3, pp.780-793

Belge Tipi: Makale

Yayın Tarihi: 5/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000726112

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Özlem SAĞLAM | Ferah Cömert ÖNDER | Tuğba GÜNGÖR | Mehmet AY | Yusuf DİLGİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2018 Vol.42 Issue 3, pp.780-793

Belge Tipi:

Makale

Yayın Tarihi:

5/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000726112

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527