Antimicrobial properties and DNA interactions studies of 3-hetarylazoquinoline-2,4-diol compounds

Fatma ÖZTÜRK; Leyla AÇIK; İzzet ŞENER; Fikret KARCI

Makale detayları

Antimicrobial properties and DNA interactions studies of 3-hetarylazoquinoline-2,4-diol compounds

Yazarlar:

Fatma ÖZTÜRK | Leyla AÇIK | İzzet ŞENER | Fikret KARCI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.293-302

Belge Tipi:

Makale

Yayın Tarihi:

1/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727659

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The purpose of the present study was to evaluate the  antimicrobial effects of 3-hetarylazoquinoline-2,4-diols (19), having  substituted or unsubstituted thiazole, benzothiazole, benzimidazole,  triazole, isoxazole, and thiadiazole moieties at the 3-position, on  bacterial and yeast strains.  In addition, compounds and DNA  interaction with pUC18 plasmid DNA were studied.  The biological  effects of these molecules were compared with potential antibiotics  ampicillin,~chloramfenicol (for bacteria), and ketoconozole (for  yeast).  According to the results, all compounds except 8 have mild to  moderate activity against some of the bacterial strains tested, and  none of the compounds have activity against the fungi C. tropicalis  and C. albicans.  Compounds 1 and 6 have moderate activities against  B. cereus and B. subtilis, and compounds 5 and 6 have moderate  activities and 1 has mild activity against E. coli.  Compound 2 has a  mild effect on all bacterial strains except E. coli ATCC 25922, P.  vulgaris, and S. aureus.  Compounds 3-5 and 7 have mild activity  against some of the bacterial strains tested.  Compound 9 has mild  activity against all bacterial strains except E. coli ATCC 25922.  Compound 8 has no antibacterial effect.  Compounds and DNA interaction results indicate that as the compounds  bind to DNA, unwinding of supercoiled form I DNA takes place to change  it from the negatively supercoiled form I to the nicked form II and  linear form III DNA. The following studies showed that, among the  synthesized compounds, 3-9 seem to be promising candidates possessing  DNA cleavage activities besides anti-microbial properties to serve as  chemical nucleases and chemotherapeutic agents.

 

The purpose of the present study was to evaluate the  antimicrobial effects of 3-hetarylazoquinoline-2,4-diols (19), having  substituted or unsubstituted thiazole, benzothiazole, benzimidazole,  triazole, isoxazole, and thiadiazole moieties at the 3-position, on  bacterial and yeast strains.  In addition, compounds and DNA  interaction with pUC18 plasmid DNA were studied.  The biological  effects of these molecules were compared with potential antibiotics  ampicillin,~chloramfenicol (for bacteria), and ketoconozole (for  yeast).  According to the results, all compounds except 8 have mild to  moderate activity against some of the bacterial strains tested, and  none of the compounds have activity against the fungi C. tropicalis  and C. albicans.  Compounds 1 and 6 have moderate activities against  B. cereus and B. subtilis, and compounds 5 and 6 have moderate  activities and 1 has mild activity against E. coli.  Compound 2 has a  mild effect on all bacterial strains except E. coli ATCC 25922, P.  vulgaris, and S. aureus.  Compounds 3-5 and 7 have mild activity  against some of the bacterial strains tested.  Compound 9 has mild  activity against all bacterial strains except E. coli ATCC 25922.  Compound 8 has no antibacterial effect.  Compounds and DNA interaction results indicate that as the compounds  bind to DNA, unwinding of supercoiled form I DNA takes place to change  it from the negatively supercoiled form I to the nicked form II and  linear form III DNA. The following studies showed that, among the  synthesized compounds, 3-9 seem to be promising candidates possessing  DNA cleavage activities besides anti-microbial properties to serve as  chemical nucleases and chemotherapeutic agents.

Makale detayları

Antimicrobial properties and DNA interactions studies of 3-hetarylazoquinoline-2,4-diol compounds

Yazarlar: Fatma ÖZTÜRK | Leyla AÇIK | İzzet ŞENER | Fikret KARCI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.293-302

Belge Tipi: Makale

Yayın Tarihi: 1/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000727659

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Fatma ÖZTÜRK | Leyla AÇIK | İzzet ŞENER | Fikret KARCI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.293-302

Belge Tipi:

Makale

Yayın Tarihi:

1/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727659

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527