Synthesis of tetrahydropyrimidinium salts and their in situ catalytic activities towards the Buchwald--Hartwig amination reaction under microwave irradiation

Liangru YANG; Huanyu BIAN; Wenpeng MAI; Pu MAO; Yongmei XIAO; Dong WEI; Lingbo QU

Makale detayları

Synthesis of tetrahydropyrimidinium salts and their in situ catalytic activities towards the Buchwald--Hartwig amination reaction under microwave irradiation

Yazarlar:

Liangru YANG | Huanyu BIAN | Wenpeng MAI | Pu MAO | Yongmei XIAO | Dong WEI | Lingbo QU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 1, pp.121-129

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000726976

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A series of asymmetrical substituted  tetrahydropyrimidinium salts and different kinds of bridged  bis-tetrahydropyrimidinium salts were prepared through the quaterization of  tetrahydropyrimidine or the dehydrogenation of hexahydropyrimidine. They  were characterized and used as NHC precursors in the palladium catalyzed  Buchwald--Hartwig amination reaction. The in situ formed catalytic system  Pd(OAc)2/tetrahydropyrimidinium and tBuOK catalyzed the amination  of heteroaryl halides and heterocyclic amines effectively, producing the  heterocyclic amine functionalized heteroaryl derivatives in high yields.

 

A series of asymmetrical substituted  tetrahydropyrimidinium salts and different kinds of bridged  bis-tetrahydropyrimidinium salts were prepared through the quaterization of  tetrahydropyrimidine or the dehydrogenation of hexahydropyrimidine. They  were characterized and used as NHC precursors in the palladium catalyzed  Buchwald--Hartwig amination reaction. The in situ formed catalytic system  Pd(OAc)2/tetrahydropyrimidinium and tBuOK catalyzed the amination  of heteroaryl halides and heterocyclic amines effectively, producing the  heterocyclic amine functionalized heteroaryl derivatives in high yields.

Makale detayları

Synthesis of tetrahydropyrimidinium salts and their in situ catalytic activities towards the Buchwald--Hartwig amination reaction under microwave irradiation

Yazarlar: Liangru YANG | Huanyu BIAN | Wenpeng MAI | Pu MAO | Yongmei XIAO | Dong WEI | Lingbo QU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2015 Vol.39 Issue 1, pp.121-129

Belge Tipi: Makale

Yayın Tarihi: 3/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000726976

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Liangru YANG | Huanyu BIAN | Wenpeng MAI | Pu MAO | Yongmei XIAO | Dong WEI | Lingbo QU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2015 Vol.39 Issue 1, pp.121-129

Belge Tipi:

Makale

Yayın Tarihi:

3/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000726976

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527