Reshaping cytoskeleton: different acts of modulatory compounds

Pelin ZOBAROĞLU; Gamze BORA

Makale detayları

Reshaping cytoskeleton: different acts of modulatory compounds

Yazarlar:

Pelin ZOBAROĞLU | Gamze BORA

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.304-311

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512949

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 

The eukaryotic cytoskeleton is composed of filamentous structures, namely microfilaments, microtubules and intermediate filaments. The cytoskeleton is an essential component of cells due to its role in various cellular functions, such as intracellular transport, organelle positioning, chromosome segregation and cytokinesis. Abnormalities in cytoskeleton, as well as associated proteins and regulatory pathways, have been shown to contribute to disease pathomechanisms including cancer and neurodegenerative diseases. Therefore, cytoskeleton is an important therapeutic target and many compounds have been identified or developed to modulate the cytoskeleton. In this review, we focused on cytoskeleton modulatory compounds and summarized their mechanisms of action.

Makale detayları

Reshaping cytoskeleton: different acts of modulatory compounds

Yazarlar: Pelin ZOBAROĞLU | Gamze BORA

Yayıncı: Istanbul University

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.304-311

Belge Tipi: Makale

Yayın Tarihi: 12/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000512949

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Pelin ZOBAROĞLU | Gamze BORA

Yayıncı:

Istanbul University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.304-311

Belge Tipi:

Makale

Yayın Tarihi:

12/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000512949

Sıklık:

Aylık

eISSN:

2587-2087