Analysis of Atenolol in Rabbit Plasma by HPLC Method

Bilal Yilmaz

Makale detayları

Analysis of Atenolol in Rabbit Plasma by HPLC Method

Yazarlar:

Bilal Yilmaz

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Mühendislik

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 1, pp.1-10

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286801

pISSN:

2149-4584

Anahtar kelimeler:

Özet:

 The goal of this research is to develop a high-performance liquid chromatography method for analyzing atenolol levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of atenolol was achieved on an Ace C18 column. The methods calibration curve was plotted between 5 and 250 ngmL. The accuracy results were better than 2.97 and the precision results were less than 6.30 in rabbit plasma for atenolol. The method had recovery values 95.8 for all samples in rabbit plasma. In addition, the validated method was used to study atenolol pharmacokinetics in rabbits. The maximum atenolol plasma concentration is 240.1  33.41 ngmL. The duration to attain the greatest atenolol concentration and the area under the curve from AUC0-12 h were 3.0  0.64 h and 1184.1  235.13 ngmL h, respectively.

 The goal of this research is to develop a high-performance liquid chromatography method for analyzing atenolol levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of atenolol was achieved on an Ace C18 column. The methods calibration curve was plotted between 5 and 250 ngmL. The accuracy results were better than 2.97 and the precision results were less than 6.30 in rabbit plasma for atenolol. The method had recovery values 95.8 for all samples in rabbit plasma. In addition, the validated method was used to study atenolol pharmacokinetics in rabbits. The maximum atenolol plasma concentration is 240.1  33.41 ngmL. The duration to attain the greatest atenolol concentration and the area under the curve from AUC0-12 h were 3.0  0.64 h and 1184.1  235.13 ngmL h, respectively.

 The goal of this research is to develop a high-performance liquid chromatography method for analyzing atenolol levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of atenolol was achieved on an Ace C18 column. The methods calibration curve was plotted between 5 and 250 ngmL. The accuracy results were better than 2.97 and the precision results were less than 6.30 in rabbit plasma for atenolol. The method had recovery values 95.8 for all samples in rabbit plasma. In addition, the validated method was used to study atenolol pharmacokinetics in rabbits. The maximum atenolol plasma concentration is 240.1  33.41 ngmL. The duration to attain the greatest atenolol concentration and the area under the curve from AUC0-12 h were 3.0  0.64 h and 1184.1  235.13 ngmL h, respectively.

 The goal of this research is to develop a high-performance liquid chromatography method for analyzing atenolol levels in rabbit plasma and apply this method to the pharmacokinetic study. The liquid-liquid extraction technique was used to prepare blood samples from rabbits. Separation of atenolol was achieved on an Ace C18 column. The methods calibration curve was plotted between 5 and 250 ngmL. The accuracy results were better than 2.97 and the precision results were less than 6.30 in rabbit plasma for atenolol. The method had recovery values 95.8 for all samples in rabbit plasma. In addition, the validated method was used to study atenolol pharmacokinetics in rabbits. The maximum atenolol plasma concentration is 240.1  33.41 ngmL. The duration to attain the greatest atenolol concentration and the area under the curve from AUC0-12 h were 3.0  0.64 h and 1184.1  235.13 ngmL h, respectively.

Makale detayları

Analysis of Atenolol in Rabbit Plasma by HPLC Method

Yazarlar: Bilal Yilmaz

Yayıncı: Erzincan Binali Yildirim University

Ana Başlıklar: Mühendislik

Dergi: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 1, pp.1-10

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286801

pISSN: 2149-4584

Atenolol

HPLC

extraction

pharmacokinetic

rabbit

Sayı

Yazarlar:

Bilal Yilmaz

Yayıncı:

Erzincan Binali Yildirim University

Ana Başlıklar:

Mühendislik

Dergi:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.16 Issue 1, pp.1-10

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286801

pISSN:

2149-4584