New flavonoid glycosides conjugates: synthesis, characterization, and evaluation of their cytotoxic activities

Sawssen SOUIEI; Fatima Bousejra-el GARAH; Mohamed Amine BELKACEM; Mansour ZNATI; Jalloul BOUAJILA; Hichem Ben JANNET

Makale detayları

New flavonoid glycosides conjugates: synthesis, characterization, and evaluation of their cytotoxic activities

Yazarlar:

Sawssen SOUIEI | Fatima Bousejra-el GARAH | Mohamed Amine BELKACEM | Mansour ZNATI | Jalloul BOUAJILA | Hichem Ben JANNET

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 2, pp.404-414

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000725769

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A series of novel halogenated 3-hydroxyflavones (3HFs)   were prepared by reacting halogenated hydroxyacetophenones with the   appropriate aromatic aldehyde. Glycosylation of 3HFs with acetobromoglucose   and deprotection of the acetyl protective groups afforded the desired   3-OOO-flavonoids glycosides in satisfactory yields. All the prepared compounds   were tested for their cytotoxic activity against HCT-116, MCF-7, and OVCAR-3   human cancer cell lines. The 3HFs exhibited higher cytotoxic activities   compared with the glycosylated flavonoids. Overall, the structure-activity   relationship study showed that the introduction of glycoside moiety at the   C-3 OH position does not improve the bioactivity.

Makale detayları

New flavonoid glycosides conjugates: synthesis, characterization, and evaluation of their cytotoxic activities

Yazarlar: Sawssen SOUIEI | Fatima Bousejra-el GARAH | Mohamed Amine BELKACEM | Mansour ZNATI | Jalloul BOUAJILA | Hichem Ben JANNET

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2019 Vol.43 Issue 2, pp.404-414

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000725769

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Sawssen SOUIEI | Fatima Bousejra-el GARAH | Mohamed Amine BELKACEM | Mansour ZNATI | Jalloul BOUAJILA | Hichem Ben JANNET

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2019 Vol.43 Issue 2, pp.404-414

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000725769

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527