Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

Yıldız GÜLKOK; Tuba BİÇER; Fatma Kaynak ONURDAĞ; Selda ÖZGEN

Makale detayları

Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

Yazarlar:

Yıldız GÜLKOK | Tuba BİÇER | Fatma Kaynak ONURDAĞ | Selda ÖZGEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.279-291

Belge Tipi:

Makale

Yayın Tarihi:

1/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727656

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

In the present study, 18 new compounds were synthesized, 9  of which were urea (9a-e, 10a-d) while the others were thiourea  (11a-e, 12a-d) derivatives.  These derivatives were prepared by the  reaction of 6-amino-5-nonsubstituted/chloro-3-methyl-2(3H)-  benzoxazolones used as key intermediates with the appropriate  isocyanates and isothiocyanates.  The chemical structures of new  compounds were confirmed by 1H-NMR, mass, and elemental analysis.  The synthesized compounds were screened for their antibacterial and  antifungal activities against some pathogenic strains.  Compounds 9a,  9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d,  thiourea derivatives, exhibited a relatively good inhibitory profile  against E. coli, with a MIC value of 32 m g/mL when compared with  the other target compounds.

 

In the present study, 18 new compounds were synthesized, 9  of which were urea (9a-e, 10a-d) while the others were thiourea  (11a-e, 12a-d) derivatives.  These derivatives were prepared by the  reaction of 6-amino-5-nonsubstituted/chloro-3-methyl-2(3H)-  benzoxazolones used as key intermediates with the appropriate  isocyanates and isothiocyanates.  The chemical structures of new  compounds were confirmed by 1H-NMR, mass, and elemental analysis.  The synthesized compounds were screened for their antibacterial and  antifungal activities against some pathogenic strains.  Compounds 9a,  9b, 9e, 10a, and 10c, urea derivatives, and compounds 12a and 12d,  thiourea derivatives, exhibited a relatively good inhibitory profile  against E. coli, with a MIC value of 32 m g/mL when compared with  the other target compounds.

Makale detayları

Synthesis of some new urea and thiourea derivatives and evaluation of their antimicrobial activities

Yazarlar: Yıldız GÜLKOK | Tuba BİÇER | Fatma Kaynak ONURDAĞ | Selda ÖZGEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.279-291

Belge Tipi: Makale

Yayın Tarihi: 1/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000727656

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Yıldız GÜLKOK | Tuba BİÇER | Fatma Kaynak ONURDAĞ | Selda ÖZGEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2012 Vol.36 Issue 2, pp.279-291

Belge Tipi:

Makale

Yayın Tarihi:

1/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000727656

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527