Brucellosis in Children: A Single-Center Experience and Clinical Evaluation in A Tertiary Care Hospital

Berfin Özgökçe Özmen; Şefika Aldaş; Suna Özdem

Makale detayları

Brucellosis in Children: A Single-Center Experience and Clinical Evaluation in A Tertiary Care Hospital

Yazarlar:

Berfin Özgökçe Özmen | Şefika Aldaş | Suna Özdem

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Çocuk Bulaşıcı Hastalıkları

Dergi:

Osmangazi Tıp Dergisi Vol.47 Issue 5, pp.759-765

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001341766

pISSN:

1305-4953

Anahtar kelimeler:

Özet:

 Brucellosis is a prevalent zoonotic disease in childhood, particularly in endemic regions. This study aimed to compare the clinical, laboratory, and serological features of bacteremic and non-bacteremic pediatric brucellosis patients.This retrospective study included 117 pediatric patients diagnosed with brucellosis between February 2017 and July 2024. Patients were classified into bacteremic n38 and non-bacteremic n79 groups according to blood culture results. Statistical analyses were performed using R version 4.5.0. Normality of continuous variables was assessed using the ShapiroWilk test. The independent samples t-test was used for normally distributed variables, and the Wilcoxon rank-sum test for non-normal distributions. Categorical variables were compared using the Pearson Chi-square or Fishers exact test, as appropriate. A p-value of 0.05 was considered statistically significant.Hospitalization was significantly more common in the bacteremic group 39.5 than in the non-bacteremic group 11.4 p  0.001, and hospital stay distribution also differed between groups p  0.035. Splenomegaly p  0.004 and arthritis p  0.001 were more frequently observed in the non-bacteremic group. Laboratory analyses revealed significantly lower hemoglobin p  0.037 and MPV mean platelet volume p  0.048 levels in bacteremic patients. No significant differences were found in CRP, ESR, WBC counts, or serological test results.Bacteremic pediatric brucellosis cases may present with fewer localized symptoms but require longer hospitalization. Reduced hemoglobin and MPV values may serve as potential indicators of bacteremia. These findings contribute to the understanding of the clinical variability of pediatric brucellosis and support early risk stratification.

 Brucellosis is a prevalent zoonotic disease in childhood, particularly in endemic regions. This study aimed to compare the clinical, laboratory, and serological features of bacteremic and non-bacteremic pediatric brucellosis patients.This retrospective study included 117 pediatric patients diagnosed with brucellosis between February 2017 and July 2024. Patients were classified into bacteremic n38 and non-bacteremic n79 groups according to blood culture results. Statistical analyses were performed using R version 4.5.0. Normality of continuous variables was assessed using the ShapiroWilk test. The independent samples t-test was used for normally distributed variables, and the Wilcoxon rank-sum test for non-normal distributions. Categorical variables were compared using the Pearson Chi-square or Fishers exact test, as appropriate. A p-value of 0.05 was considered statistically significant.Hospitalization was significantly more common in the bacteremic group 39.5 than in the non-bacteremic group 11.4 p  0.001, and hospital stay distribution also differed between groups p  0.035. Splenomegaly p  0.004 and arthritis p  0.001 were more frequently observed in the non-bacteremic group. Laboratory analyses revealed significantly lower hemoglobin p  0.037 and MPV mean platelet volume p  0.048 levels in bacteremic patients. No significant differences were found in CRP, ESR, WBC counts, or serological test results.Bacteremic pediatric brucellosis cases may present with fewer localized symptoms but require longer hospitalization. Reduced hemoglobin and MPV values may serve as potential indicators of bacteremia. These findings contribute to the understanding of the clinical variability of pediatric brucellosis and support early risk stratification.

 Brucellosis is a prevalent zoonotic disease in childhood, particularly in endemic regions. This study aimed to compare the clinical, laboratory, and serological features of bacteremic and non-bacteremic pediatric brucellosis patients.This retrospective study included 117 pediatric patients diagnosed with brucellosis between February 2017 and July 2024. Patients were classified into bacteremic n38 and non-bacteremic n79 groups according to blood culture results. Statistical analyses were performed using R version 4.5.0. Normality of continuous variables was assessed using the ShapiroWilk test. The independent samples t-test was used for normally distributed variables, and the Wilcoxon rank-sum test for non-normal distributions. Categorical variables were compared using the Pearson Chi-square or Fishers exact test, as appropriate. A p-value of 0.05 was considered statistically significant.Hospitalization was significantly more common in the bacteremic group 39.5 than in the non-bacteremic group 11.4 p  0.001, and hospital stay distribution also differed between groups p  0.035. Splenomegaly p  0.004 and arthritis p  0.001 were more frequently observed in the non-bacteremic group. Laboratory analyses revealed significantly lower hemoglobin p  0.037 and MPV mean platelet volume p  0.048 levels in bacteremic patients. No significant differences were found in CRP, ESR, WBC counts, or serological test results.Bacteremic pediatric brucellosis cases may present with fewer localized symptoms but require longer hospitalization. Reduced hemoglobin and MPV values may serve as potential indicators of bacteremia. These findings contribute to the understanding of the clinical variability of pediatric brucellosis and support early risk stratification.

 Bruselloz, çocukluk çağında endemik bölgelerde sık görülen önemli bir zoonotik enfeksiyondur. Bu çalışmada, bakteriyemik ve bakteriyemik olmayan çocukluk çağı bruselloz olgularının klinik, laboratuvar ve serolojik özelliklerinin karşılaştırılması amaçlanmıştır.Bu retrospektif çalışmada, Şubat 2017 - Temmuz 2024 tarihleri arasında bruselloz tanısı almış 117 çocuk hasta değerlendirildi. Hastalar, kan kültürü sonucuna göre bakteriyemik n38 ve bakteriyemik olmayan n79 olarak iki gruba ayrıldı. Verilerin analizinde R versiyon 4.5.0 yazılımı kullanıldı. Sürekli değişkenlerde normallik dağılımı ShapiroWilk testi ile değerlendirildi. İkili karşılaştırmalarda parametrik veriler için bağımsız gruplar t-testi, parametrik olmayanlar için Wilcoxon testi kullanıldı. Kategorik değişkenlerde Pearson ki-kare veya Fisher exact testleri uygulandı. p0,05 anlamlı kabul edildi.Bakteriyemik hastalarda hastaneye yatış oranı 39,5, bakteriyemik olmayanlara göre 11,4 anlamlı olarak yüksekti p0,001. Yatış süresi dağılımı da gruplar arasında farklıydı p0,035. Splenomegali p0,004 ve artrit p0,001, bakteriyemik olmayan grupta daha sık görüldü. Laboratuvar bulgularında, bakteriyemik grupta hemoglobin düzeyi p0,037 ve MPV ortalama trombosit hacmi p0,048 anlamlı olarak daha düşüktü. CRP, ESR, WBC ve serolojik test sonuçlarında gruplar arasında anlamlı fark saptanmadı.Bakteriyemik çocukluk çağı bruselloz olgularında lokal bulgular daha az izlenmekte ancak hastaneye yatış ihtiyacı daha fazla olmaktadır. Düşük hemoglobin ve MPV değerleri, bakteriyeminin olası göstergeleri olarak düşünülebilir. Elde edilen bulgular, çocukluk çağı brusellozunun klinik çeşitliliğine ışık tutmakta ve erken risk sınıflaması açısından katkı sağlamaktadır.

Makale detayları

Brucellosis in Children: A Single-Center Experience and Clinical Evaluation in A Tertiary Care Hospital

Yazarlar:

Berfin Özgökçe Özmen | Şefika Aldaş | Suna Özdem

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Çocuk Bulaşıcı Hastalıkları

Dergi:

Osmangazi Tıp Dergisi Vol.47 Issue 5, pp.759-765

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001341766

pISSN:

1305-4953

Brucellosis

childhood

Brucella melitensis

blood culture

zoonotic infectionBruselloz

çocukluk çağı

Brucella melitensis

kan kültürü

zoonotik enfeksiyon

Sayı

Makale detayları

Yazarlar: Berfin Özgökçe Özmen | Şefika Aldaş | Suna Özdem

Yayıncı: Eskişehir Osmangazi University

Ana Başlıklar: Çocuk Bulaşıcı Hastalıkları

Dergi: Osmangazi Tıp Dergisi Vol.47 Issue 5, pp.759-765

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001341766

pISSN: 1305-4953

Sayı

Yazarlar:

Berfin Özgökçe Özmen | Şefika Aldaş | Suna Özdem

Yayıncı:

Eskişehir Osmangazi University

Ana Başlıklar:

Çocuk Bulaşıcı Hastalıkları

Dergi:

Osmangazi Tıp Dergisi Vol.47 Issue 5, pp.759-765

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001341766

pISSN:

1305-4953