Incidence and risk factors of nephrotoxicity associated with intravenous colistin use in the intensive care unit

Ökkeş Hakan MİNİKSAR; Erol TOY

doi:https://doi.org/10.28982/josam.953207

Makale detayları

Incidence and risk factors of nephrotoxicity associated with intravenous colistin use in the intensive care unit

Yazarlar:

Ökkeş Hakan MİNİKSAR | Erol TOY

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar | Hastalıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 8, pp.750-754

Belge Tipi:

Makale

Yayın Tarihi:

7/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498610

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.953207

Özet:

 

Background/Aim: The most serious side effect of colistin therapy is nephrotoxicity. This study aimed to investigate the incidence of nephrotoxicity (NT) due to intravenous colistin and determine the associated risk factors in critically ill patients in the intensive care unit (ICU).
Methods: This retrospective cohort study was conducted by examining the files of 100 patients who were hospitalized in the ICU and received intravenous colistin therapy. According to the RIFLE criteria, the patients were divided into two groups as those with and without nephrotoxicity. The clinical characteristics of the patients were compared between the groups and the risk factors associated with nephrotoxicity were determined by multivariate linear logistic regression analysis.
Results: The mean age, mean length of stay in the ICU, and mortality rate of 44 patients included in the study were 68±16.36 years, 77.14 (83.03) days, and 56.8%, respectively. NT developed in 22 (50%) patients during colistin therapy. In those with NT, diabetes mellitus, chronic obstructive pulmonary disease, and coronary artery disease were significantly more common (P<0.05 for all), the mean age (P<0.001), Charlson age-adjusted comorbidity index (CACI) scores, APACHE scores (P=0.010) were higher and albumin level was lower (P=0.001). High CACI scores (B=0.532, P=0.002) and low albumin levels (B=-0.323, P=0.023) were significant risk factors for colistin NT according to the regression analysis.
Conclusion: Nephrotoxicity is significantly common among critically ill patients receiving colistin therapy. Patients with high CACI scores and hypoalbuminemia should be followed up closely for nephrotoxicity.

Makale detayları

Incidence and risk factors of nephrotoxicity associated with intravenous colistin use in the intensive care unit

Yazarlar: Ökkeş Hakan MİNİKSAR | Erol TOY

Yayıncı: Fatih BAŞAK

Ana Başlıklar: Cerrahi ve ilgili tıbbi uzmanlıklar | Hastalıklar

Dergi: Journal of Surgery and Medicine 2021 Vol.5 Issue 8, pp.750-754

Belge Tipi: Makale

Yayın Tarihi: 7/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000498610

Sıklık: Aylık

eISSN: 2602-2079

DOI: https://doi.org/10.28982/josam.953207

Sayı

Yazarlar:

Ökkeş Hakan MİNİKSAR | Erol TOY

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar | Hastalıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 8, pp.750-754

Belge Tipi:

Makale

Yayın Tarihi:

7/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498610

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.953207