Predictive values of plasma KL-6 in bronchopulmonary dysplasia in preterm infants

Dilek DİLLİ; Ahmet ÖZYAZICI; Arzu DURSUN; Serdar BEKEN; Nurdan Dinlen FETTAH; Aysegul ZENCİROĞLU; Nurullah OKUMUŞ

Makale detayları

Predictive values of plasma KL-6 in bronchopulmonary dysplasia in preterm infants

Yazarlar:

Dilek DİLLİ | Ahmet ÖZYAZICI | Arzu DURSUN | Serdar BEKEN | Nurdan Dinlen FETTAH | Aysegul ZENCİROĞLU | Nurullah OKUMUŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.621-626

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751472

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: It has been suggested that plasma KL-6 increases in premature infants with bronchopulmonary dysplasia (BPD). We  aimed to evaluate the predictive values of KL-6 in BPD.  Materials and methods: The study was performed in preterm neonates with birthweight ≤1500 g and gestational age ≤32 weeks. Plasma  KL-6 levels were measured on postnatal days 1, 7, and 14.  Results: BPD was identified in eight of the 28 study infants. On postnatal days 1 and 7, plasma KL-6 levels were similar in infants with  BPD [on day 1: 8.9 (7.5-17.8) U/mL and on day 7: 16.8 (10.5-47.7) U/mL] and without BPD [on day 1: 10.8 (9.4-17.2) U/mL and on  day 7: 12.9 (5.8-19.3) U/mL] (P = 0.38 and P = 0.13, respectively). On day 14, KL-6 levels were significantly higher in infants with BPD  [155.2 (15.3-545.6) U/mL] than they were in infants without BPD [7.9 (7.7-15.6) U/mL] (P = 0.001). The best predictor was KL-6 levels  on postnatal day 14 (area under the ROC curve = 0.88; range 0.75-1.0; P = 0.002). At this point, KL-6 level of 59.7 U/mL showed a  specificity of 90.0% and negative predictive value of 85.7% for BPD.  Conclusion: High plasma KL-6 levels on postnatal day 14 in premature infants may predict the development of BPD.

Makale detayları

Predictive values of plasma KL-6 in bronchopulmonary dysplasia in preterm infants

Yazarlar: Dilek DİLLİ | Ahmet ÖZYAZICI | Arzu DURSUN | Serdar BEKEN | Nurdan Dinlen FETTAH | Aysegul ZENCİROĞLU | Nurullah OKUMUŞ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.621-626

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751472

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Dilek DİLLİ | Ahmet ÖZYAZICI | Arzu DURSUN | Serdar BEKEN | Nurdan Dinlen FETTAH | Aysegul ZENCİROĞLU | Nurullah OKUMUŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.621-626

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751472

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144