Synthesis and Antibacterial Evaluation of Novel Benzimidazole, Benzothiazole, Benzofurane, and Naphtofurane Derivatives of Aminothiazoles

Zafer ŞAHİN; Büşra Işıl TOK; Erol AKGÜN; Erol AKGÜN; Ayşegül ÇAŞKURLU; Leyla YURTTAŞ; Barkın BERK; Şeref DEMİRAYAK

Makale detayları

Synthesis and Antibacterial Evaluation of Novel Benzimidazole, Benzothiazole, Benzofurane, and Naphtofurane Derivatives of Aminothiazoles

Yazarlar:

Zafer ŞAHİN | Büşra Işıl TOK | Erol AKGÜN | Erol AKGÜN | Ayşegül ÇAŞKURLU | Leyla YURTTAŞ | Barkın BERK | Şeref DEMİRAYAK

Yayıncı:

FABAD Ankara Eczacılık Bilimleri Derneği

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Fabad Journal of Pharmaceutical Sciences 2022 Vol.47 Issue 2, pp.231-240

Belge Tipi:

Makale

Yayın Tarihi:

7/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000779158

Sıklık:

Üç Yıllık

eISSN:

2651-4648

pISSN:

1300-4182

Özet:

 

The thiazole ring is the core of bioactive molecules that
generate broad activity. These activities include anticonvulsant,
antimicrobial, antituberculosis, antiviral, etc. In this work, starting
from seconder/cyclic amines, new compounds containing thiazole
and benzimidazole/benzothiazole/benzofurane/naphtofurane rings
were synthesized, and their antimicrobial effects were evaluated. 9
compounds were synthesized by converting the seconder and cyclic
amines to thiourea, and continued by thiazole ring closure. Ring
closure was achieved by methylene-carbonyl condensation except
conventional methods. Compound characterization was realized by
FT-IR, 1H NMR and 13C NMR and HRMS. Compounds did not
show significant activity on bacterial strains. Nine aminothiazole
derivatives have been synthesized successfully. Compounds did not
show important antibacterial activity and thus were evaluated as
inactive.

Makale detayları

Synthesis and Antibacterial Evaluation of Novel Benzimidazole, Benzothiazole, Benzofurane, and Naphtofurane Derivatives of Aminothiazoles

Yazarlar: Zafer ŞAHİN | Büşra Işıl TOK | Erol AKGÜN | Erol AKGÜN | Ayşegül ÇAŞKURLU | Leyla YURTTAŞ | Barkın BERK | Şeref DEMİRAYAK

Yayıncı: FABAD Ankara Eczacılık Bilimleri Derneği

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: Fabad Journal of Pharmaceutical Sciences 2022 Vol.47 Issue 2, pp.231-240

Belge Tipi: Makale

Yayın Tarihi: 7/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000779158

Sıklık: Üç Yıllık

eISSN: 2651-4648

pISSN: 1300-4182

Sayı

Yazarlar:

Zafer ŞAHİN | Büşra Işıl TOK | Erol AKGÜN | Erol AKGÜN | Ayşegül ÇAŞKURLU | Leyla YURTTAŞ | Barkın BERK | Şeref DEMİRAYAK

Yayıncı:

FABAD Ankara Eczacılık Bilimleri Derneği

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Fabad Journal of Pharmaceutical Sciences 2022 Vol.47 Issue 2, pp.231-240

Belge Tipi:

Makale

Yayın Tarihi:

7/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000779158

Sıklık:

Üç Yıllık

eISSN:

2651-4648

pISSN:

1300-4182