Hemofagositik lenfohistiyositoz hastalarında kraniyal MRG bulguları

Cenk ERASLAN; Elçin AYDIN; Eltan MAHARRAMOVA; Akkız ŞAHİN; Hamiyet HEKİMCİ ÖZDEMİR; Deniz YILMAZ KARAPINAR; Cem ÇALLI; Ömer KİTİŞ

Makale detayları

Hemofagositik lenfohistiyositoz hastalarında kraniyal MRG bulguları

Yazarlar:

Cenk ERASLAN | Elçin AYDIN | Eltan MAHARRAMOVA | Akkız ŞAHİN | Hamiyet HEKİMCİ ÖZDEMİR | Deniz YILMAZ KARAPINAR | Cem ÇALLI | Ömer KİTİŞ

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Ege Journal of Medicine 2018 Vol.57 Issue 1, pp.14-18

Belge Tipi:

Makale

Yayın Tarihi:

2/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000954023

Anahtar kelimeler:

Özet:

 


Aim: Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome characterized by hyperinflammation causing uncontrolled immune response. It is classified as primary and secondary according to etiology. Fever, splenomegaly, hepatitis are among the clinical findings. The diagnosis is made with tissue sampling. The central nervous system (CNS) involvement of familial HLH patients is a factor that affects the prognosis and course of the disease. The findings of CNS involvement include progressive encephalopathy, irritability, attack, cranial nerve paralysis, ataxy, nistagmus, walking and visual impairment, psychomotor development deficiency. In this study, we aimed at presenting the radiologic imaging findings of 6 cases with CNS involvement.

Materials and Methods: Six patients between the ages of 1-11 years applied to our hospital with neurological findings such as irritability, attack, cranial nerve paralysis, ataxy, nistagmus, walking and visual impairment, psychomotor development deficiency. Following the neurological examination, the cranial magnetic resonance imaging (MRI) examination was conducted.

Results: HLH diagnosis was made through bone marrow biopsy after clinical and laboratory evaluations. Cranial MRI findings indicating CNS involvement were observed in all of our patients. Hyperintense foci in cerebral hemispheres and pathological contrast enhancement in postcontrast series were defined in T2 and FLAIR sequences in MRI examination.

Conclusion: The central nervous system involvement of HLH disease is observed with high mortality and morbidity. Cranial MRI plays a significant role in revealing CNS involvement.

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Makale detayları

Hemofagositik lenfohistiyositoz hastalarında kraniyal MRG bulguları

Yazarlar:

Cenk ERASLAN | Elçin AYDIN | Eltan MAHARRAMOVA | Akkız ŞAHİN | Hamiyet HEKİMCİ ÖZDEMİR | Deniz YILMAZ KARAPINAR | Cem ÇALLI | Ömer KİTİŞ

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Ege Journal of Medicine 2018 Vol.57 Issue 1, pp.14-18

Belge Tipi:

Makale

Yayın Tarihi:

2/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000954023

Hemofagositik lenfohistiyositoz

manyetik rezonans görüntüleme

santral sinir sistemi

immun

Sayı

Makale detayları

Hemofagositik lenfohistiyositoz hastalarında kraniyal MRG bulguları

Yazarlar: Cenk ERASLAN | Elçin AYDIN | Eltan MAHARRAMOVA | Akkız ŞAHİN | Hamiyet HEKİMCİ ÖZDEMİR | Deniz YILMAZ KARAPINAR | Cem ÇALLI | Ömer KİTİŞ

Ana Başlıklar: Sağlık teşvikleri

Dergi: Ege Journal of Medicine 2018 Vol.57 Issue 1, pp.14-18

Belge Tipi: Makale

Yayın Tarihi: 2/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000954023

Hemofagositik lenfohistiyositoz

manyetik rezonans görüntüleme

santral sinir sistemi

immun

Sayı

Yazarlar:

Cenk ERASLAN | Elçin AYDIN | Eltan MAHARRAMOVA | Akkız ŞAHİN | Hamiyet HEKİMCİ ÖZDEMİR | Deniz YILMAZ KARAPINAR | Cem ÇALLI | Ömer KİTİŞ

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Ege Journal of Medicine 2018 Vol.57 Issue 1, pp.14-18

Belge Tipi:

Makale

Yayın Tarihi:

2/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000954023