Voltammetric analysis of disulfiram in pharmaceuticals with a cyclic   renewable silver amalgam film electrode

SYLWIA SMARZEWSKA; NATALIA FESTINGER; MONIKA SKOWRON; DARIUSZ GUZIEJEWSKI; RADOVAN METELKA; MARIOLA BRYCHT; WITOLD CIESIELSKI

Makale detayları

Voltammetric analysis of disulfiram in pharmaceuticals with a cyclic renewable silver amalgam film electrode

Yazarlar:

SYLWIA SMARZEWSKA | NATALIA FESTINGER | MONIKA SKOWRON | DARIUSZ GUZIEJEWSKI | RADOVAN METELKA | MARIOLA BRYCHT | WITOLD CIESIELSKI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2017 Vol.41 Issue 1, pp.116-124

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000726476

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Electrochemical properties of disulfiram, representative   of highly significant bioactive compounds, were studied with a cyclic   renewable silver amalgam film electrode (Hg(Ag)FE) using square wave   cathodic stripping voltammetry (SWCSV). The influence of various factors   such as pH, buffer concentration, buffer composition, and SWCSV parameters   on current response was investigated. The optimum results in terms of signal   shape and intensity were recorded in Britton--Robinson buffer (pH 7.5) at   -0.5 V versus Ag/AgCl/3 mol L−1−1^{-1} KCl. An elaborated electroanalytical   procedure was used to determine disulfiram at the Hg(Ag)FE in the   concentration range from 0.05 to 5.00 μμ\mu M. Precision, repeatability, and   accuracy of the method as well as the influence of possible interferences   were ascertained. The detection and quantification limits were 11 nM and 37   nM, respectively. The applicability of the developed method was tested in   the determination of disulfiram in the commercial formulation Anticol.   Thin-layer chromatography with image processing software was used to   validate the accuracy of the method.

Makale detayları

Voltammetric analysis of disulfiram in pharmaceuticals with a cyclic renewable silver amalgam film electrode

Yazarlar: SYLWIA SMARZEWSKA | NATALIA FESTINGER | MONIKA SKOWRON | DARIUSZ GUZIEJEWSKI | RADOVAN METELKA | MARIOLA BRYCHT | WITOLD CIESIELSKI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2017 Vol.41 Issue 1, pp.116-124

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000726476

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

SYLWIA SMARZEWSKA | NATALIA FESTINGER | MONIKA SKOWRON | DARIUSZ GUZIEJEWSKI | RADOVAN METELKA | MARIOLA BRYCHT | WITOLD CIESIELSKI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2017 Vol.41 Issue 1, pp.116-124

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000726476

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527