A prospective randomized study comparing vaginal dinoprostone plus oxytocin versus oxytocin alone for labor induction in nulliparous women with unripe cervix

Eser Ağar

Makale detayları

A prospective randomized study comparing vaginal dinoprostone plus oxytocin versus oxytocin alone for labor induction in nulliparous women with unripe cervix

Yazarlar:

Eser Ağar

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.383-387

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357462

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: To compare the effectiveness and outcomes of two medications oxytocin and dinoprostone used for cervical ripening and labor induction. Methods: Term nulliparous pregnant women with Bishop score 4 who received labor induction indication were divided into two groups. The first group received vaginal dinoprostone followed by oxytocin. The second group received only oxytocin only. Labor onset times, delivery duration, Bishop scores, contraction frequencies every 10 minutes, cesarean rates, and Apgar scores of newborns were compared between the two groups. Results: Although there was no statistically significant difference in terms of active labor onset time between the dinoprostone and oxytocin groups, a significant difference was observed regarding the time to delivery. dinoprostone: 873.5219.12 minutes; oxytocin: 637.4339.3 minutes; p0.0001. A significant difference was also found between the two groups in terms of mean Bishop scores at 2, 4, 6, 8, and 10 hours. p0.0001, p0.0001, p0.008, p0.033, respectively. Similarly, there was a significant difference between the two groups regarding contraction frequency per 10 minutes in the first 2 hours of induction. dinoprostone: 0.220.4210 minutes; oxytocin: 0.720.8810 minutes; p0.0001 No statistically significant difference was found between the two groups in terms of cesarean rates. However, it was determined that the oxytocin group had a 2.06 times higher probability of undergoing cesarean section compared to the other group. OR:2.06 0.83-5.10, 95 CI. The mean 1st minute Apgar score of babies in the dinoprostone group was 6.490.19 and the 5th minute Apgar score mean was 9.100.11. The mean 1st minute Apgar score of babies in the oxytocin group was 6.800.17 and the 5th minute Apgar score mean was 8.800.15, with no statistical significance detected between the two groups p0.05. Conclusion: Dinoprostone can be preferred as a method to reduce cesarean rates; however, oxytocin may be preferred in clinics with high patient density due to its faster effect and quicker completion of delivery.

 Aims: To compare the effectiveness and outcomes of two medications oxytocin and dinoprostone used for cervical ripening and labor induction. Methods: Term nulliparous pregnant women with Bishop score 4 who received labor induction indication were divided into two groups. The first group received vaginal dinoprostone followed by oxytocin. The second group received only oxytocin only. Labor onset times, delivery duration, Bishop scores, contraction frequencies every 10 minutes, cesarean rates, and Apgar scores of newborns were compared between the two groups. Results: Although there was no statistically significant difference in terms of active labor onset time between the dinoprostone and oxytocin groups, a significant difference was observed regarding the time to delivery. dinoprostone: 873.5219.12 minutes; oxytocin: 637.4339.3 minutes; p0.0001. A significant difference was also found between the two groups in terms of mean Bishop scores at 2, 4, 6, 8, and 10 hours. p0.0001, p0.0001, p0.008, p0.033, respectively. Similarly, there was a significant difference between the two groups regarding contraction frequency per 10 minutes in the first 2 hours of induction. dinoprostone: 0.220.4210 minutes; oxytocin: 0.720.8810 minutes; p0.0001 No statistically significant difference was found between the two groups in terms of cesarean rates. However, it was determined that the oxytocin group had a 2.06 times higher probability of undergoing cesarean section compared to the other group. OR:2.06 0.83-5.10, 95 CI. The mean 1st minute Apgar score of babies in the dinoprostone group was 6.490.19 and the 5th minute Apgar score mean was 9.100.11. The mean 1st minute Apgar score of babies in the oxytocin group was 6.800.17 and the 5th minute Apgar score mean was 8.800.15, with no statistical significance detected between the two groups p0.05. Conclusion: Dinoprostone can be preferred as a method to reduce cesarean rates; however, oxytocin may be preferred in clinics with high patient density due to its faster effect and quicker completion of delivery.

 Aims: To compare the effectiveness and outcomes of two medications oxytocin and dinoprostone used for cervical ripening and labor induction. Methods: Term nulliparous pregnant women with Bishop score 4 who received labor induction indication were divided into two groups. The first group received vaginal dinoprostone followed by oxytocin. The second group received only oxytocin only. Labor onset times, delivery duration, Bishop scores, contraction frequencies every 10 minutes, cesarean rates, and Apgar scores of newborns were compared between the two groups. Results: Although there was no statistically significant difference in terms of active labor onset time between the dinoprostone and oxytocin groups, a significant difference was observed regarding the time to delivery. dinoprostone: 873.5219.12 minutes; oxytocin: 637.4339.3 minutes; p0.0001. A significant difference was also found between the two groups in terms of mean Bishop scores at 2, 4, 6, 8, and 10 hours. p0.0001, p0.0001, p0.008, p0.033, respectively. Similarly, there was a significant difference between the two groups regarding contraction frequency per 10 minutes in the first 2 hours of induction. dinoprostone: 0.220.4210 minutes; oxytocin: 0.720.8810 minutes; p0.0001 No statistically significant difference was found between the two groups in terms of cesarean rates. However, it was determined that the oxytocin group had a 2.06 times higher probability of undergoing cesarean section compared to the other group. OR:2.06 0.83-5.10, 95 CI. The mean 1st minute Apgar score of babies in the dinoprostone group was 6.490.19 and the 5th minute Apgar score mean was 9.100.11. The mean 1st minute Apgar score of babies in the oxytocin group was 6.800.17 and the 5th minute Apgar score mean was 8.800.15, with no statistical significance detected between the two groups p0.05. Conclusion: Dinoprostone can be preferred as a method to reduce cesarean rates; however, oxytocin may be preferred in clinics with high patient density due to its faster effect and quicker completion of delivery.

 Amaçlar: Servikal olgunlaştırma ve doğum indüksiyonu için kullanılan iki ilacın oksitosin ve dinoproston etkinliğinin ve sonuçlarını kıyaslamak. Yöntemler: Doğum indüksiyonu endikasyonu almış Bishop skoru 4 olan term nullipar gebeler iki gruba ayrıldı. Birinci gruba vajinal dinoproston ve devamında oksitosin verildi. İkinci gruba ise sadece oksitosin verildi. Her iki gruptaki hastaların travaya giriş süreleri, doğum süreleri, Bishop skorları, her 10 dakikadaki kontraksiyon frekansları, sezaryen oranları ve bebeklerin Apgar skorları karşılaştırıldı. Bulgular: Dinoproston ve oksitosin gurubunda aktif travay başlangıç süresi açısından istatistiksel olarak anlamlı bir fark olmamasına rağmen, doğuma kadar geçen süre açısından anlamlı bir fark gözlendi. Dinoproston: 873,5219,12 dakika; Oksitosin: 637,4339,3 dakika; p0,0001. 2, 4, 6, 8,10. saatlerdeki Bishop skoru ortalamaları açısından da iki grup arasında anlamlı fark saptandı. Sırasıyla p0,0001, p0,0001, p0,008, p0,033. Aynı şekilde, indüksiyonun ilk 2 saatinde 10 dakikadaki kontraksiyon sıklığı açısından her iki grup arasında anlamlı fark olduğu görüldü. Dinoproston: 0,220,4210 dakika; Oksitosin: 0,720,8810 dakika; p0,0001 Sezaryen oranları açısından iki grup arasında istatistiksel olarak anlamlı fark saptanmadı. Buna rağmen, oksitosin grubunun sezaryene gitme ihtimalinin diğer gruba oranla 2.06 kat daha fazla olduğu tespit edildi. OR:2,06 0,83-5,10.. 95CI. Dinoproston grubundaki hastaların bebeklerinin 1. dakika Apgar skoru ortalaması 6,490,19 ve 5. dakika Apgar skoru ortalaması 9,100,11 olarak saptandı. Oksitosin grubundaki bebeklerin 1. dakika Apgar skoru ortalaması 6,800,17 ve 5. dakika Apgar skoru ortalaması ise 8,800,15 olarak bulundu ve iki grup arasında istatistiksel anlamlılık tespit edilmedi p0,05. Sonuç: Dinoproston sezaryen oranlarını azaltmak için tercih edilebilecek bir yöntemdir ancak oksitosin, daha hızlı etki göstermesi ve doğumu daha hızlı sonuçlandırması sebebi ile hasta yoğunluğu yüksek olan kliniklerde tercih edilebilir.

Makale detayları

A prospective randomized study comparing vaginal dinoprostone plus oxytocin versus oxytocin alone for labor induction in nulliparous women with unripe cervix

Yazarlar:

Eser Ağar

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.383-387

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357462

pISSN:

2717-7505

Cervical ripening

labor induction

oxytocin

dinoprostoneservikal olgunlaştırma

doğum indüksiyonu

oksitosin

dinoproston

Sayı

Makale detayları

Yazarlar: Eser Ağar

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kadın Hastalıkları ve Doğum

Dergi: Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.383-387

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357462

pISSN: 2717-7505

Sayı

Yazarlar:

Eser Ağar

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum

Dergi:

Journal of Medicine and Palliative Care Vol.6 Issue 4, pp.383-387

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357462

pISSN:

2717-7505