The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave

Asli Vural; Oguz Dikbas; Selahattin Vural; Hümeyra Bozoğlan; Bircan Sönmez

Makale detayları

The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave

Yazarlar:

Asli Vural | Oguz Dikbas | Selahattin Vural | Hümeyra Bozoğlan | Bircan Sönmez

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Cardiovascular Surgery

Dergi:

The European Research Journal Vol.9 Issue 2, pp.200-206

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283005

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Despite strong evidence regarding the impact of radioactive iodine RAI on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer DTC patients with and without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy Group 1; n  33, the second group included patients with DTC who did not receive RAI following total thyroidectomy Group 2; n  34. The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected Group 3; n  37. All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract. Results: Presystolic wave was more common in subjects receiving RAI Group 1 compared to Group 2 those without RAI 90.9 vs. 61.8 respectively, p  0.003, and its prevalence in Group 3 was 54.1. Multiple logistic regression analysis revealed that receiving RAI OR: 4.922, 95 CI: 1.640  20.022, p  0.004 was independently associated with a 5-fold higher risk for the presence of a presystolic wave. Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.

 Objectives: Despite strong evidence regarding the impact of radioactive iodine RAI on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer DTC patients with and without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy Group 1; n  33, the second group included patients with DTC who did not receive RAI following total thyroidectomy Group 2; n  34. The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected Group 3; n  37. All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract. Results: Presystolic wave was more common in subjects receiving RAI Group 1 compared to Group 2 those without RAI 90.9 vs. 61.8 respectively, p  0.003, and its prevalence in Group 3 was 54.1. Multiple logistic regression analysis revealed that receiving RAI OR: 4.922, 95 CI: 1.640  20.022, p  0.004 was independently associated with a 5-fold higher risk for the presence of a presystolic wave. Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.

 Objectives: Despite strong evidence regarding the impact of radioactive iodine RAI on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer DTC patients with and without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy Group 1; n  33, the second group included patients with DTC who did not receive RAI following total thyroidectomy Group 2; n  34. The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected Group 3; n  37. All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract. Results: Presystolic wave was more common in subjects receiving RAI Group 1 compared to Group 2 those without RAI 90.9 vs. 61.8 respectively, p  0.003, and its prevalence in Group 3 was 54.1. Multiple logistic regression analysis revealed that receiving RAI OR: 4.922, 95 CI: 1.640  20.022, p  0.004 was independently associated with a 5-fold higher risk for the presence of a presystolic wave. Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.

 Objectives: Despite strong evidence regarding the impact of radioactive iodine RAI on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer DTC patients with and without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy Group 1; n  33, the second group included patients with DTC who did not receive RAI following total thyroidectomy Group 2; n  34. The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected Group 3; n  37. All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract. Results: Presystolic wave was more common in subjects receiving RAI Group 1 compared to Group 2 those without RAI 90.9 vs. 61.8 respectively, p  0.003, and its prevalence in Group 3 was 54.1. Multiple logistic regression analysis revealed that receiving RAI OR: 4.922, 95 CI: 1.640  20.022, p  0.004 was independently associated with a 5-fold higher risk for the presence of a presystolic wave. Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.

Makale detayları

The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave

Yazarlar:

Asli Vural | Oguz Dikbas | Selahattin Vural | Hümeyra Bozoğlan | Bircan Sönmez

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Cardiovascular Surgery

Dergi:

The European Research Journal Vol.9 Issue 2, pp.200-206

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283005

pISSN:

2149-3189

Differentiated thyroid cancer

radioactive iodine

echocardiography

presystolic wave

Sayı

Makale detayları

The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave

Yazarlar: Asli Vural | Oguz Dikbas | Selahattin Vural | Hümeyra Bozoğlan | Bircan Sönmez

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Cardiovascular Surgery

Dergi: The European Research Journal Vol.9 Issue 2, pp.200-206

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001283005

pISSN: 2149-3189

Differentiated thyroid cancer

radioactive iodine

echocardiography

presystolic wave

Sayı

Yazarlar:

Asli Vural | Oguz Dikbas | Selahattin Vural | Hümeyra Bozoğlan | Bircan Sönmez

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Cardiovascular Surgery

Dergi:

The European Research Journal Vol.9 Issue 2, pp.200-206

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283005

pISSN:

2149-3189